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남문석(Moon Suk Nam),정준표(Jun Pyo Chung),이홍우(Hong Woo Lee),오제열(Je Yol Oh),박효진(Hyo Jin Pack),이관식(Kwan Sik Lee),이상인(Sang In Lee),박인서(In Suh Park),이안나(An Na Lee),송경순(Kyung Soon Song) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.2
Behcets disease is a systemic disease involving skin, joint, gastrointestinal tract, vascular and nervous systems, characterized by recurrent oral and genital ulcerations and ocular in- flammation. The intestinal Behcets disease has nonspecific abdominal symptoms of colicky pain, constipation, diarrhea, nausea, vomiting, and malabsorption. Therefore, we need to dif- ferentiate with other diseases having nonspecific abdominal symptoms. We have experienced a case of lead intoxication after ingestion of herbal pills believed to contain lead compounds. A 40 year-old female with known Behcet's disaese was admitted due to acute colicky abdominal pain. The cause of abdominal pain and anemia was investigated and intestinal Behcets disease was ruled out. The diagnosis of lead intoxication was made by careful history, clinical manifestations, and various laboratory findings including peripheral blood smear, bone marrow aspiration and biopsy, serum lead and free erythrocyte protoporphyrin levels. W e also used lead mobilization test for measure of chelatable lead level. The treatment was performed with 4 courses of EDTA infusion therapy and the clinical symptoms and chemical data associated with lead intoxication improved.(Korean J Gastroen- terol 1994; 26: 399 404)
당뇨병성 백서에서 Vanadate 투여후 혈당의 변화와 근육세포내 포도당운반체 활성도 및 유전자의 조절
이현철(Hyun Chul Lee),남문석(Moon Suk Nam),이은직(Eun Jig Lee),임승길(Seung Kil Lim),김경래(Kyung Rae Kim),허갑범(Kap Bum Huh),정윤석(Yoon Sok Chung),이관우(Kwan Woo Lee),조용욱(Yong Wook Cho) 대한내과학회 1995 대한내과학회지 Vol.48 No.3
N/A Objectives: Vanadate is known to mimic several effect of insulin including the stimulation of glucose uptake and oxidation, glycogen synthesis as well as the anti-lipolytic effect. But mechanisms for these effects of vanadate are still not completely understood. The aim of this study was to elucidate the effects of vanadate on intrinsic activity of the glucose transporter and the regulation of the glucose transporter mRNA. Methods: Using age and weight-matched male Sprague-Dawley rats (average weight 250 g), the experimental groups were divided into nondiabetic rats (n= 6), streptozotocin (STZ)-induced diabetic rats (n=6), metavanadate and pervanadate treated diabetic rats (n =12). We measured weight, blood glucose, glucose transporter activity, and glucose transporter 4 (GLUT4) mRNA change. Results: 1) STZ-induced diabetic rats became catabolic and they lost their weight, but after 3 to 4 weeks of treatment with metavanadate or pervanadate, body weights were increased. Blood glucose levels in metavanadate or pervanadate treated rats were significantly lower than STZ-induced diabetic rats after 1 week treatment. 2) There was no significant toxicity in vanadates treated rats, compared with STZ-induced diabetic rats and there was no abnormal change in kidney and liver of rats under light microscope 8 weeks after vanadates treatment. 3) The glucose transporter activity of diabetic rats was significantly decreased, compared with that of normal control rats, and increased after vanadates treatment. 4) The glucose transporter mRNA of diabetic rats was markedly decreased, compared with that of normal control rats, and increased after vanadates treatment. Conclusion: In STZ-induced diabetic rats, vanadates treatment may improve insulin sensitivity through in- creased expression of GLUT4 gene.