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흰쥐 자궁에 유도된 염증으로 인한 substance P와 CGRP에 대한 면역반응의 변화
나중열(Joong Yol Na),장기훈(Ki Hoon Chang),유상욱(Sang Wook You),홍순철(Soon Choul Hong),이서은(Seo Eun Lee),한희철(Hee Chul Han) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5
N/A Objective : Recently some reports suggested substance P and CGRP might be important factors for inflammation and hyperalgesia. This study was performed to see whether substance P or CGRP containing nerve fibers might be changed by mustard oil-induced inflammation. Methods : After injection of mustard oil(5%) into uterine lumen, the uteri were removed and examined with immunohistochemical methods for substance P and CGRP. Results : In the normal uterus, most of the substance P- or CGRP-immunoreactive nerve fibers were observed along the vascular structure and some in the myometrium, only few in the endometrium. Mustard oil did not changed this pattern of nerve fiber distribution but after 48 hrs, the amount of substance P or CGRP immunoreactive nerve fibers were greatly reduced compared with the normal uterus. It is not clear whether the decrease of substance P and CGRP immunoreactive fibers in the uterus was resulted from the depletion of the neuropeptides in the nerve fibers or the retraction of nerve fibers. Conclusions : These results suggest that the inflammation should cause the change of nerve fibers included in the nociception. This change may attribute the generation of inflammation and inflammatory hyperalgesia.
Substance P에 의한 자궁의 기계적 수용체의 활동 변화에 대한 전기 생리학적 고찰
나중열(Joong Yol Na),장기훈(Ki Hoon Chang),신재철(Jae Chul Shin),유상욱(Sang Wook You),홍순철(Soon Choul Hong),이서은(Seo Eun Lee),한희철(Hee Chul Han) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4
N/A Objective : In inflammation, hyperalgesia is a common phenomenon but its mechanism has not been clarified. Recently some reports suggested substance P might be important factors for inflammatory hyperalgesia in somatic tissue. This study was performed to see whether substance P modulate the activities of uterine afferent fibers in the hypogastric nerve of the cat. Methods : While recording the electrical activities of nerve fibers, mechanical stimuli were applied as balloon distention using balloon inserted into uterine lumen before and during substance P infusion through uterine artery. Results : Substance P increased the responses to balloon distension of uterus in 14 uterine mechanoreceptive afferent fibers of 24 over 10% compared to before substance P infusion, and decreased the responses of 3. And L-703,606, the neurokinin 1 receptor antagonist failed the modulation of mechanosensitive response by substance P and reduced the spontaneous activities. Conclusions : These results suggest that substance P modulated the activities of uterine nerve fibers and their responses to mechanical stimulus. It is hypothesized that this kind of modulation of afferent nerve fibers by substance P may be important for the development of inflammatory hyperalgesia.
박지원(Ji Won Park),홍서유(Seo You Hong),나중열(Joong Yol Na) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.10
목적: 기능성 자궁출혈이란 자궁의 해부학적 병변없이 자궁내막으로부터의 비정상출혈로 부인과 질환중 10-15%의 빈도를 차지할 정도로 비중있는 질환이지만, 진단이 용이하지 않고 치료 방법 또한 매우 다양하여 앞으로 더 많은 연구가 필요하므로 임상적 양상과 병리조직학적 상호관계를 알아보고자 본 연구를 시행하였다. 연구방법: 1988년 1월부터 1997년 12월까지 10년간 고려대학교 의과대학 부속 안암병원 산부인과에 비정상적 자궁출혈을 주소로 내원한 환자중 자궁내막 소파술을 이용한 자궁내막 생검결과 기능성 자궁출혈로 진단된 599례를 대상으로 연령분포, 임신 및 분만경력, 출혈양상, 자궁내막의 조직변화와 자궁내막 소파시기에 따른 조직학적 소견을 비교 검토하였다. 결과: 연령분포는 40대가 245례(40.9%)로 가장 많았고 평균연령은 44.1세였으며, 출혈양상은 월경간 출혈이 189례(31.6%), 월경과다가 150례(25.0%), 폐경후 출혈이 135례 (22.5%)순이었다. 자궁내막의 조직학적 소견은 증식기 내막이 327례(54.6%)로 가장 많았으며 내막증식증이 139례(23.2%), 분비기 내막이 74례(12.4%)의 순이었다. 출혈양상에 따른 조직학적 소견의 분포는 희발월경을 제외한 모든 경우에서 증식기 내막이 가장 많았으며 그 다음으로 내막증식증, 분비기 내막의 순으로 전체 조직학적 소견의 분포와 동일하여 출혈양상에 따른 조직학적 소견의 차이는 없는 것으로 나타났다. 결론: 본 연구에서는 이전의 다른 연구들에 비해 조직학적 소견상 자궁내막 증식증을 보이는 경우가 많았는데 특히 40대 이상의 연령군에서 높은 빈도를 보여 이 연령 이상의 환자에서 비정상 자궁출혈이 관찰되는 경우 반드시 자궁내막생검을 통하여 조직학적 소견을 확인하여야 하며 자궁내막증식증으로 진단된 경우 자궁내막암으로 진행할 가 능성이 있으므로 향후 추적관찰에 주의를 기울여야 할 것이다. Objectives: Dysfunctional uterine bleeding(DUB) is defined as abnormal bleeding from the uterine endometrium unrelated to anatomic lesions of the uterus, and its incidence is 10-15% among gynecologic diseases. We conducted this study for understanding correlation between clinical aspecets and pathological findings of DUB. Methods: We conducted a retrospective review of 599 women with DUB who underwent endometrial biopsy with special regard to the relation between pathologic findings and presenting symtoms or complaints from Jan. 1988 to Dec. 1997. Results: Age distribution of DUB was mainly 5th decade, mean age was 44.1years, among various bleeding patterns, intermenstrual bleeding was the most common pattern(31.6%) and the next was menorrhagia(25.0%). Histologic findings of endometrium were proliferative phase, 327 cases(54.6%), hyperplasia, 139 cases(23.2%), secretory phase, 74 cases(12.4%) in order of frequency, and there was no difference in distribution of histologic findings among various bleeding patterns. Conclusion: Compared to other previoius studies, our study showed more incidence of endometrial hyperplasia, especially at age group of 40 or more. So patients aged more than this age with abnormal uterine bleeding must undergo emdometrial biopsy for pathologic diagnosis. Patients who are diagnosed endometrial hyperplasia must be carefully followed up because there are possibilities of progression to endometrial carcinoma.
최보율(Bo Yul Choi),최삼섭(Sam Sup Choi),나중열(Joong Yol Na),정명현(Myung Hyun Chung) 한국의학교육학회 1994 Korean journal of medical education Vol.5 No.2
We looked for and discussed the changes of curricula of medical course of 31 medical schools during the period of 1984 and 1993. The data used in this study were Educational State Report of Korean Med ical Schools published from Dean Association of Korean Medical Schools in 1984 and 1992-1993. The significant findings were as follows. 1. There were great variability in number of subjects and in time for lecture and exercise in each subject among 31 medical schools. 2. There were a great deal of changes during the period of 1984 and 1993. There were increased tendency in number of subjects and especially block lectures. Schools which had 1-4 subjects vanished in curriculum were most frequent among 22 schools during 9 years. Name of most frequent subjects in block lecture were clinico-patholo gical conference, reproductive medicine, hematology, oncology and cardiology in 1993. 3. Subjects which were transferred to pre-medical program were classified to two groups. One group was traditional basic medical subjects such anatomy, physiology and biochemistry, the other group was newly introduced subjects such as molecular biology and cell biology as basic medical subjects. 4. The data were suggested that long time was needed to stabilized in newly introduced subjects of clinical medicine such as neurology and plastic surgery. Time for lecture and exercise of these subjects shows increasing tendency in schools established before 1978, but decreasing tendency in schools established after 1978.
Salmonella typhi감염에 의해 발생한 난소 농양
조금준 ( Geum Joon Cho ),이지영 ( Ji Young Lee ),장재혁 ( Jae Hyuk Chang ),정유아 ( Yu A Jeong ),이영석 ( Young Seok Lee ),나중열 ( Joong Yol Na ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.3
Samonella infection is usually a short febrile self-limiting disease localized to the gut, acquired by ingestion of contaminated food or water. The infection is seldom accompanied by extraintestinal complication. If such a complication does occur, the abs