급성 일산화탄소 중독시 단순 흉부 X-선 소견

나우연 최신의학사 1979 最新醫學 Vol.22 No.9

X-선 전신조사가 마우스의 혈청 Cholesterol ester 에 미치는 영향

나우연 대한영상의학회 1970 대한영상의학회지 Vol.6 No.1

In the view of the importance of esterified and free cholesterol in lipid metabolism, as well as serum transaminase activity in the liver, the present study was designated to elucidate the effects of whole body X-irradiation on the levels of esterified cholesterol, free cholesterol and activity of serum transaminase in mouse. Also, in order to observe possible radioprotective action of reduced glutathione, a combination of X-irradiation and injection of GSH was done to see the effects of GSH on lipid metabolism.

食道穿孔

羅雨淵 최신의학사 1975 最新醫學 Vol.18 No.4

Esophageal perforation has been uncommonly reported condition. Perforation are always secondary to a disease process. A 43-year-old farmer male awakened at 2:00A. M. with severe abdominal pain followed by vomiting but not associated with blood loss. Previous history included duodenal ulcer for 9 months duration relived by medical ulcer regimen. Initial radiographs of the chest and abdomen revealed pleural effusion on the right thorax and sickle shaped free air under the both diaphragms. Early X-Ray diagnosis will lead to prompt surgery, a requisite for survival.

Reduced Glutathione 및 人蔘抽出液이 分劃 X線 全身照射를 입은 마우스 肝組織과 血中의 NP-SH 및 NP-SS에 미치는 影響

羅雨淵,朱永恩 慶北大學校 醫科大學 1973 慶北醫大誌 Vol.14 No.2

放射線保護物質로서 그 有效性이 認定되고 있는 reduced glutathione (GSH)의 保護作用을 더욱 깊이 理解하고 또한 最近 sulfhydryl (SH)基가 含有되어 있다고 알려진 人蔘抽出液의 X線保護作用의 有無와 그 程度를 알기 爲하여 마우스를 材料로 하고 GSH는 體重 gm當 1mg을 lml의 Kreb's Ringr phosphate 溶液中에 溶解한 것과 또한 人蔘抽出液은 1ml中에 SH複合體 2.4μmol이 含有된 것을 每日 腹腔內로 注射하고 이것을 4日間 繼續하였으며 X線全身照射는 每日 300R씩의 線量을 4日間 照射하는 分劃의 方法으로서 總量 1,200R을 照射하였으며 以上의 實驗條作을 單獨 또는 倂用한 名群으로 나누었다. 實驗時間은 比較的 長時間의 成績을 얻기 爲해서 30, 60 및 120分에서 實驗한 第1實驗과, 初期인 30分까지의 變化를 細分해서 觀察하기 爲하여 5, 10, 20 및 30分으로 細分한 第2實驗으로 大別하였고 各 實驗群의 各 實驗時間에서 肝組織에서는 non-protein sulfhydryl (NP-SH) 및 non-protein disulfide (NP-SS)를 定量하였고 血中에서는 NP-SH를 正量하여 正常群의 그것과 서로 比較하였다. 그 結果를 要約하면 다음과 같다. 1. 마우스 肝組織의 NP-SH의 正常値는 5.90±0.46μmol/gm wet wt.이며 NP-SS는 3.02±0.42μ mol/gm wet wt.이었고 血中 NP-SH는 3.98±1.29μmol/ml이었다. 2. 肝組織의 NP-SH는 分劃X線照射만으로서는 30分에서 對照에 比하여 높아져서 60分에서는 最高値를 나타낸 後 120分에서는 對照値로 돌아왔으며 GSH 單獨投與로서는 30分 및 60分에서 모두 높은 값을 維持한 120分에서는 若干 低下되었다. 그러나 人蔘抽出液投與로서는 30分, 60分 및 120分에서 모두 對照에 比하여 큰 變動이 없었다. 한편 GSH와 分劃X線照射를 倂用했을 때는 30分에서 NP-SH가 가장 높아진 後 60分 및 120分에서는 對照値와 비슷하였다. 3. 實驗初期인 30分 동안의 肝組織의 NP-SH의 變動은 全實驗群에서 5分에서 對照에 比하여 높은 값을 나타내었고 그後는 大體로 30分까지 若干 低下되는 傾向이었고 그 程度는 GSH投與群, 分劃X線照射群, GSH와 分劃X線照射의 倂用群, 人蔘抽出液과 分劃X線照射倂用群의 順序이었으며 人蔘抽出液單獨投與群에서는 그 傾向이 가장 낮았다. 4. 肝組織의 NP-SS는 長期實驗에서는 大體로 全群에서 30分에 最高値를 보인後 120分까지 徐徐히 低下되었고 그 程度는 人蔘抽出液과 分劃X線照射의 倂用群, GSH 單獨投與群, 人蔘抽出液 單獨投與群 및 分劃X線照射群의 順序이었으나 GSH 投與와 分劃X線照射를 倂用했을 대는 實驗後半에서 높은 NP-SS의 값을 얻었다. 5. 30分까지의 NP-SS의 變化를 觀察한 實驗에서는 大體로 全群에서 5分에서의 變化가 가장 뚜렷하였고 그 程度는 分劃X線照射群이 가장 顯著하였고 人蔘抽出液投與群에서 가장 낮았다. 그러나 GSH投與 및 人蔘抽出液 投與後 分劃X線照射를 한 群에서는 30分까지 높은 값이 維持되었다. 6. 血中 NP-SH는 30分에서 GSH와 人事抽出液 單獨投與로서는 相當히 높아진 後 120分가지 徐徐히 低下되었으나 分劃 X線對照群과 GSH投與와 分劃X線照射를 倂用한 群에서는 오히려 60分에서 相當히 낮은 값을 보인 後 120分에서는 對照値로 돌아왔다. 7. 實驗初期인 30分까지의 血中 NP-SP의 變動은 全群에서 5分에서 높고 그後 30分까지는 徐徐히 低下되는 傾向을 보였고 그 程度는 GSH投與群, 人蔘抽出液投與群 및 分劃X線照射群를의 順序이었으나 人蔘抽出液과 分劃X線照射群를 倂用한 群에서는 30分까지 對照에 比하여 큰 差異가 없었다. 8. 以上의 結果로서 GSH의 放射線 保護作用은 全實驗을 通하여 認定할 수 있으나 人蔘抽出液은 投與後 30分까지 에서만, 그 保護作用을 認定할 수 있겠다. Of the sulfhydryl substances which have been studied for the possible radioprotective actions when injected into the animal prior to ionizing radiation, reduced glutathione (GSH) has been proved to be the most effective. Lately, Oh reported that the extract from Panax Ginseng contains some amount of sulfhydryl group and suggested the applicability of the extract as radioprotector. In the present study, an effort was directed to further clarify the radioportective action of GSH, and to observe a possible readioprotective action of Ginseng extract. The mouse was subjected to whole body X-irradiation in fractionated daily dose of 300R for four days, either independently or immediately following the injection of 1ml of GSH containing 1mg GSH per gm body weight, or Ginseng extract containing 2.4μmol of sulfhydryl suastance, to the mouse intraperitoneally. The experiment was divided into two parts. In the first experiment, the time of observation was set at 30, 60 and 120 min, and in the second experiment, the time interval was further divided as 5, 10, 20, and 30 min in order to observe radioprotectice actions of GSH and Ginseng extract within the relatively shorter period. The non-protein sulfhydry1 (NP-SiH) and non-protein disulfide (NP-SS) levels of the liver, and NP-SH level of the blood of the mouse were measured in the first and second experiments, and the results were compared with the normal values. The results thus obtained are summarized as follows. 1) The normal values of NP-SH and NP-SS of the mouse liver were 5.90±0.46/μmol/gm wet. wt., and 3.02±0.42/μmol/gm wet wt., respectively, and the normal value of NP-SH of the mouse blood was 3.98±1.29/μmol/ml. 2) The highest liver NP-SH was observed at 60 min in fractionated x-irradiation group and GSH injected group, but in Ginseng injected group, the liver NP-SP was similar to the control value trhoughouth the experiment. When GSH and fractionated X-irradiation were combined, the liver NP-SP was the highest at 60 min, but when Ginseng extract was injected perior to fractionated X-irradiation, the highest liver NP-SH was observed at 30 min. 3) When the change of the liver NP-SH was observed within 30 min, a tendency of the highest value at 5 min followed by the decrease at 30 min was observed, and the tendency was most prominent when Ginseng extract and fractionated X-irradiation were combined. 4) The liver NP-SS showed the highest values at 30 min in most groups, but when GSH was combined with fractionated X-irradiation, higher liver NP-SS was observed at the latter part of the experiment. 5) Within 30 min of the experiment, the liver NP-SS showed a general tendency of the highest values at 5 min in most groups, with the exception of GSH injected group and combined group of Gineng extract and fractionated X-irradiation, where the liver NP-SS were elevated till 30 min. 6) The blood NP-SP were elevated at 30 min in GSH and Ginseng extract injected groups, but in fractionated X-irradiation, the blood NP-SH were highest at 60 min before decreasing to the control value at 120 min. 7) The blood NP-SP within 30 min of the experiment showed a general tendency of the elevated value at 5 min followed by a decrease at 30 min, but in the group where Ginseng extract and fractionated X-irradiation were combined, the blood NP-SH did not change from the control till 30 min. 8) From the above results, he radioprotective action of GSH is demonstrated througout the experiment, but the radioportective action of the Ginseng extract seems to be limited only within 30 min of the injection.

Reduced Glutathione 및 人蔘抽出液이 分劃 X線 全身照射를 입은 마우스 肝組織과 血中의 NP-SH및 NP-SS에 미치는 影響

羅雨淵,朱永恩 慶北大學校 醫科大學 1973 慶北醫大雜誌 Vol.14 No.2

膽石症 手術後 患者에 있어서 胃十二指腸 潰瘍과의 關係에 對하여

羅雨淵 최신의학사 1977 最新醫學 Vol.20 No.5

The upper G-1 series was emploied in the evaluation of 50 patients whom had underwent cholecystectomy with cholelithiasis. In 13 patients (26%) with peptic ulcer, gastric ulcer was 6 cases and duodenal ulcer was 7 cases. Why pyloric closure is at- fault in cholecystectomized patient is not clear. But -one possibility is duodenal regurgitation.

신결핵에 대한 방사선학적 고찰

김시운,나우연,김용주 대한영상의학회 1981 대한영상의학회지 Vol.17 No.3

Radiolographic findings of thirty eight cases of renal tuberculosis treated at this hospital during last 4 years were analysed with following results. The cases examined were 24 male and 14 female patients. Age distribution was broad and evenly distributed ranging form 2nd decases to 5th decades. Main symtoms complained were urinary frequency , hematuria, dysuria and flank pain. Findings of physical examinatin revealed tenderness of costovertevral angle, palpable mass on flank area and epidydimal indutration. The simple chest films showed pulmonary tuberculosis in 22 cases including 6 cases of active military type. Thirty one cases showed increased ESR, 8 cases showed AFB positive inurine and 12 cases showed bilateral renal tuberculosis. Through urographic findings nonvisualization, cyceopelviectasis, motheaten appearance of minor calyx, contracted bladder, delayed visualization, ureteral st icture and beading were observed in order of frequency. Five cases with miliary tuberculosis showed advanced renal lesion on urogram.

Ehrlich Ascites Carcinoma조직 추출물의 항암효과

朴三均,羅雨淵,鄭泰浩 慶北大學校 醫科大學 1976 慶北醫大雜誌 Vol.17 No.2

Ehrilich Ascites Carcinoma에 대한 Tubercin-3와 5-Fluorouracil의 치료효과

全石吉,羅雨淵,鄭泰浩 慶北大學校 醫科大學 1976 慶北醫大雜誌 Vol.17 No.2

各種 疾患者에 對한 X-線照射時 Tubercin-3 投與가 血淸蛋白의 電氣泳動像에 미치는 效果(第1報) : 特히 子宮頸部癌 25例에 對한 觀察

徐俊洙,崔漢鏞,羅雨淵,鄭泰浩 慶北大學校 醫科大學 1976 慶北醫大雜誌 Vol.17 No.1