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딱지꽃(Potentilla chinensis) 뿌리 추출물의 주요성분 분리동정
정해수 ( Hae Soo Jung ),김형식 ( Hyoung Shik Kim ),이정훈 ( Jeong Hun Lee ),모서진 ( Seo Jin Moh ),여진희 ( Jin Hui Yeo ),박기원 ( Gi Won Park ),모상현 ( Sang Hyun Moh ) 한국응용생명화학회 2016 Journal of Applied Biological Chemistry (J. Appl. Vol.59 No.1
딱지꽃(Potentilla chinensis)은 약초식물의 하나로 항염, 지혈, 해독 그리고 해열 등의 효과가 알려져 있다. 특히 딱지꽃의 뿌리는 약제로써 중요한 가치를 지니고 있다. 그러나 기존에 딱지꽃의 줄기나 잎에 대한 유효성분에 대한 연구가 시도된 반면 딱지꽃의 뿌리의 주요성분을 분석한 사례가 없었다. 따라서 본 연구는 딱지꽃의 뿌리를 다양한 용매별로 추출하고 주요한 물질을 분리정제 하였다. 분리 정제된 물질을 NMR과 mass 분석을 통하여 물질을 동정하였고 그 결과 주요성분이 화합물 (1)임을 확인하였다. 또한, 동정된 물질의 산업적 응용을 위해 딱지꽃 뿌리에서 용매별로 화합물 (1) 추출양을 정량하였다. One of oriental medicinal plants, Potentilla chinensis, has been used for anti-inflammation, hemostatic, decryption, and antipyretic. Especially, a root of Potentilla chinensis was used as important material for oriental medication. Although several kinds of bioactive component of Potentilla chinensis extract from stems and leaves were identified, the major component of Potentilla chinensis from roots is not well established. In this study, the root of Potentilla chinensis was extracted in different solvent system and analyzed by high performance liquid chromatography (HPLC). According to HPLC analysis, a major component was isolated and its physic℃hemical properties were evaluated by mass spectrometry and nuclear magnetic resonance. Based on these results, isolated compound was identified as 2,3,8-Tri-O-methylellagic acid. And quantification of 2,3,8-Tri-O-methylellagic acid with different extraction solvent system was performed for industrial application.
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모상현(Sang Hyun Moh),정대현(Dai Hyun Jung),김형식(Hyoung Shik Kim),조문진(Moon Jin Cho),서효현(Hyo Hyun Seo),김성준(Sung Jun Kim) 한국생물공학회 2011 KSBB Journal Vol.26 No.6
Bioactive peptides (BAP) showed excellent cosmetic activity than bio-materials such as caffeic acid (CA), gallic acid (GA), and nicotinic acid (NA). Caffeoyl tripeptide-1 (CT-1) is a BAP that is stabilized with Gly-His-Lys (GHK) tripeptide and CA by using Fmoc solid phase peptide synthesis. Digalloyl tetrapeptide-19 (DT-19) is stabilized by combining Lys-Glu-Cys-Gly with GA and nicotinoyl tripeptide-1 (NT-1) is synthesized by GHK and NA. According to experiments, CT-1 has an excellent anti-oxidant function even with a very small amount of 10 ppm CT-1. DT-19’s tyrosinase inhibition activity has the better effect of about 28.57% in 0.01% and 33.33% in 0.005% of concentration and about 7.89% in 0.001% concentration than vitamin-C. In addition, NT-1 is safer than the NA. Almost BAPs like pal-KTTKS, acetyl hexapeptide, and copper tripeptide-1 have the anti-wrinkle effect while DT-19 and NT-1 are applicable for potential BAPs focused on the whitening effect. The three kinds of BAPs like CT-1, DT-19, and NT-1 consisting of amino acids are safe to the skin, and have more excellent stability than bio-materials which are found to be unstable and cause skin irritation. Due to the high biological activity of BAP in the field of skin care, its utilization will increase constantly.
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모상현(Sang-Hyun Moh),이정훈(Jeong-Hun Lee),김형식(Hyoung-Shik Kim),여진희(Jin-Hui Yeo) 한국화장품미용학회 2015 한국화장품미용학회지 Vol.5 No.3
As natural plant-based industry has been expanded, the use of oriental medicinal plants as cosmeceutical material was received a lot of attentions in the cosmetic industry. Among various medicinal plants, Potentilla chinensis have been interested in its biological effects. Although several attempts were tried to study its biological effect as medicinal plant, only limited studies tried to evaluate its biological effect as cosmeceutical material. In this study, we examined the possibility of Potentilla chinensis extract as a cosmeceutical material. After extraction of Potentilla chinensis, biological evaluation including anti-inflammation, anti-wrinkle, whitening effect and moisturizing effect was performed as cosmeceutical material. As a result, the Potentilla chinensis extract showed remarkable biological activities through stimulating elastin and aquaporin-3, and inhibiting melanin synthesis, cyclooxygenase-2 expression and expression of metallopeptidase-1, respectively. These results show the potential use of Potentilla chinensis as a functional cosmetic material for anti-inflammatory, wrinkle improvement, skin hydration and whitening effects.
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화장품 소재로써의 딱지꽃(Potentilla chinensis) 뿌리 추출물의 효과
유재천 ( You Jae Chon ),정해수 ( Hae Soo Jung ),김형식 ( Hyoung Shik Kim ),이정훈 ( Jeong Hun Lee ),모상현 ( Sang Hyun Moh ) 한국응용생명화학회 2016 Journal of Applied Biological Chemistry (J. Appl. Vol.59 No.1
천연물을 이용한 산업이 증가됨에 따라 전통약재식물들의 화장품 소재로 사용하려는 관심이 높아지고 있다. 다양한 약재식물중 딱지꽃(Potentilla chinensis) 역시도 다양한 약리 활성이 알려짐에 따라 관심이 높아지고 있다. 그러나 다양한 약리활성을 지닌 반면 딱지꽃(Potentilla chinensis) 을 이용한 산업적 응용은 거의 이루어지지 않고 있다. 본 연구에서는 화장품소재로서의 딱지꽃 뿌리 추출물에 관현 연구를 수행하였다. 그 이유는 딱지꽃의 뿌리 부분이 다른 부분보다 더 많은 약리활성을 지녔다는 보고들이 있었기 때문이다. 딱지꽃 뿌리 추출물을 얻어낸뒤 항염증, 주름개선, 보습 그리고 미백 효과를 확인함에 따라 딱지꽃 뿌리 추출물을 화장품 소재로 응용가능한지 확인하였다. 그 결과 elastin과 aquaporin-3 증가 효과를 확인할 수 있었고, cyclooxygenase-2, metallopeptidase-1 그리고 melanin 합성 억제효과를 확인할 수 있었다. As natural plant-based industry has been expanded, the use of oriental medicinal plants as cosmeceutical material received a lot of attentions in the cosmetic industry. Among various medicinal plants, Potentilla chinensis have drawn interests for its biological effects. Although several attempts were tried to study its biological effect as medicinal plant, only limited results were reported to evaluate its biological effect as cosmeceutical material. In this study, we examined the possibility of root extract from Potentilla chinensis as a cosmeceutical material because the root part has been reported to have several kinds of health promoting effects. After extraction of roots, biological evaluation including anti-inflammation, anti-wrinkle, whitening effect and moisturizing effect was performed. As a result, the root extract showed remarkable biological activities through stimulating synthesis of elastin and aquaporin-3, and inhibiting melanin synthesis, cyclooxygenase-2 expression and expression of metallopeptidase-1.
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