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Papyriflavonol A, a new prenylated flavonol from Broussonetia papyrifera
Son, K.H.,Kwon, S.J.,Chang, H.W.,Kim, H.P.,Kang, S.S. 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
A new prenylated flavonol, papyriflavonol A, was isolated from the root barks of Broussonetia papyrifera. The structure of this compound was elucidated as 5, 7, 3', 4' -tetrahydroxy- 6,5' -di-(y, y-dimethylallyl)-flavonol (1) by spectroscopic analysis.
Antiinflammatory Activity of Lonicera japonica
Lee, S. J.,Son, K. H.,Chang, H. W.,Kang, S. S.,Kim, H. P. 영남대학교 약품개발연구소 1999 영남대학교 약품개발연구소 연구업적집 Vol.9 No.-
As port of our investigations into new antiinflammatory agents based on plant extracts, the n-butanol (BuOH) fraction of Lonicerα jeponirα was prepared and its antilnfiammatory actlvity was evaluated using several experimental animal models of inflammation. At oral doses of 100-400 mg/kg, the BuOH fraction showed antiinflammatory activity against acute, granulomatic and chronic inflnmmation models in mice and rats. Although the activity was not comPared with prednisolone, the results suPPort the traditional use and suggest that this fraction of L. japonicα may yield a safe and mild antiinflammatory agent for treating various inflammatory disorders. ⓒ 1998 John Wiley & Sons, Ltd.
A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa
Moon, T. C.,Murakami, M.,Kudo, I.,Son, K. H.,Kim, H. P.,Kang, S. S.,Chang, H. W. 영남대학교 약품개발연구소 2000 영남대학교 약품개발연구소 연구업적집 Vol.10 No.-
Objective and Design: We investigated the effect of a new class of COX-2 inhibitor, rutaecarpine, on the production of PGD, in bone marrow derived mast cells(BMMC) and PGE_(2) in bone marrow derived mast cells (BMMC) and PGE_(2) in COX-2 transfected H다293 cells. Inflammation was induced by λ-carrageenan in male Splague-Dawley(SD) rats. Material: Rutaecarpine(8, 13-Dihydroindolo[2', 3':3,4]pyridol[2,1-b]quinazolin-5(7H)-one) was isolated from the fruits of Evodia rutaecarpa. BMMC were cultured with WEHI-3 conditioned medium. c-Kit ligand and IL-10 were obtained by their expression in baculovirus. Methods: The generation of PGD_(2) and PGE_(2) were determined by their assay kit. COX-1 and COX-2 protein and mRNA expression was determined by BMMC in the presence of KL, LPS and IL-10. Treatment: Rutaecarpine and indomethacin dissolved in 0.1% carboxymethyl cellulose was administered intraperitoneally and, 1h later, λ-carrageenan solution was in-jucted to right hind paw of rats. Paw volumes were measured using plethysmometer 5h after λ-carrageenan injection. Results: Rutaecarpine inhibited COX-2 and COX-1 dependent phases of PGD_(2) generation in BMMC in a concentration-dependent manner with an IC_(50) of 0.28 μM and 8.7μM, respectively. It inhibited COX-2-dependent conversion of exogenous arachidonic acid to PGE_(2) in a dose-dependent manner by the COX-2-transfected HEK293 cells. However, rutaecarpine inhibited neither PLA_(2) and COX-1 activity nor COX_(2) protein and the mRNA expression up to the concentration of 30μM in BMMC, indicating that retaecarpine directly inhibited COX-2 activity. Furthermore, rutaecarpine showed in vivo anti-inflammatory activity on rat λ-carrageen-an induced paw edema by intraperitoneal administration. Conclusion: Anti-inflammatory activity of Evodia rutaecarpa could be attributed at least in part by inhibition of COS-2.