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한국인 남성에서 자폐스펙트럼장애와 DLX6 유전자 단일염기다형성간 연관성 연구
김현근(Hyoun Geun Kim),원성식(SeongSik Won),이승구(Seung Ku Lee),남민(Min Nam),방희정(Hee Jung Bang),박현정(Hyun Jung Park),윤진영(Jin Young Yoon),최경식(Kyung-Sik Choi),홍미숙(Mee Sook Hong),정주호(Joo-Ho Chung),곽규범(KyuBum Kwack 대한소아청소년정신의학회 2010 소아청소년정신의학 Vol.21 No.1
Objectives:Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by abnormalities of social functioning, communication and behavior. The association of the 7q21-34 region with ASD has been reported. The DLX6 gene, which is located at the 7q22 region, is one of the positional and functional candidate genes for ASD. We found that there is no association between DLX6 polymorphisms and ASD in the Korean male population. Methods:We selected three single nucleotide polymorphisms (SNPs) that might be implicated in the change of the DLX6 gene expression. The genomic DNA was collected from the venous blood of 147 male controls and 179 male patients with ASD. The genotypes of the selected SNPs were determined using the Illumina GoldenGate assay, and the statistical analyses were performed using HapAnalyzer software and SAS Enterprise. Results:We found no association of the three SNPs in the DLX6 gene with ASD in the Korean male population. Conclusion:Our study suggests that the three SNPs in the DLX6 gene are not associated with ASD, and we need to analyze the previously reported regions for their associations with ASD.