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수종 생약수침엑기스가 알러지 반응 및 혈청단백분획에 미치는 영향에 관한 연구
김창종(Chang Johng Kim),정진모(Jin Mo Chung) 한국생약학회 1985 생약학회지 Vol.16 No.1
The antiallergic activities of water extract 35 traditional Chinese drugs have been assessed from their relative activities in the passive-cut aneous anaphylaxis(PCA) reaction in the MCS of Ab-sensitized rats. It was found that seven Chinese drugs, Cocculi Trilobi Lignum, Coptidits Rhizoma,Phellodendri Cortex, Elutherococci Cortex, Glycyrrhizae Radix, Achyranthis Radix, Eucommiae Cortex were more active than others in the PCA test. Especially, above seven Chinese drugs inhibited the acute allergic reaction such as passive cutaneous anaphylaxis by mast cell-sensitizing anti body and histamine-induced anaphylaxis, and the delayed allergic reaction such as the Freund`s complete adjuvant arthritis and the DNCB-induoed dermatitis. Their activities ascertained that the Chinese drugs decrease the capillary permeability and the serum γ-globulin level. Water extracts of seven Chinese drugs act as the mast cell stabilizer that inhibit the degranulation of mast cell in the subcutaneous connective tissue of the MCSAb-sensitized rats.
동물성 소염진통제(I) -구인다당체분획의 소염,진통 및 면역억제작용-
김창종(Chang Johng Kim),최윤석(Yun Seuk Choi),조승길(Seung Kil Cho) 대한약학회 1991 약학회지 Vol.35 No.2
Effects of Allolobophora caliginosatrapezoides (Ac) polysaccharide fractions on the inflammation and hypersensitivity were studied in vivo. It showed that Ac polysaccharide fractions have the significant inhibitory activities of inflammation and hypersensitivity; They inhibited significantly the carrageenin-induced paw edema and acetic acid-induced writhing syndrome. They also inhibited significantly the Arthus reaction and delayed hypersensitivity in the sheep red blood cell-sensitized mice in accordance with the inhibition of haemaglutinin titer, haemolysin titer, plaque-forming cells and rosette-forming cells. They also improved markedly the oxazolone-induced dermatitis in rats dose-dependently. As the above results, it exhibited that Ac polysaccharide fraction inhibited not only humoral immune response, but also cell-mediated immune response. It seemed that methanol and ether extracts have also another physiological active agents.
Flavonoids의 약리작용(I) -Flavonoies 구조와 과민반응 억제작용과의 상관성-
김창종(Chang Johng Kim),정진모(Jin Mo Chung) 대한약학회 1990 약학회지 Vol.34 No.5
The activities of twenty-one flavonoids and their related compounds on the hypersensitivity reaction against various antigens were studied in vitro and in vivo. 1.Generally flavonoids inhibited significantly the homologous passive cutaneous anaphylaxis (PCA) induced by reaginic antibody as compared as anaphylaxis by compound 48/80-induced mast cell degranulation, and so more strongly active in the IgE-mediated anaphylaxis than non-IgE-mediated anaphylaxis. 2.Flavonoids inhibited remarkably Arths reaction, hemolysin titer, delayed hypersensitivity, haemaggltitinin titer, rosette forming cells and plague forming cells against sheep red blood cells, and so it exhibited that flavonoids inhibited type 2, 3 and 4 hypersensitivity. 3.Quercetin, kaempferol, hesperetin, disodium cromoglycate, malvin and baicalein were active dose-dependently in the all types of hypersensitivity. Fisetin, daidzein, morin, narigin, flavone, catechin, rutin, hesperidin, neophsperidin, apigenin and chrysin were significantly active in the various types of hypersensitivity, but apigenin, rutin and catechin were less active in the delayed hypersensitivity. Taxifolin was significantly active in PCA and histamine-induced anaphylaxis except other types of hypersensitivity. Rotenone and cyanin also inhibited all types of hypersensitivity, but they are toxic. 4.Based on these results from hypersensitivity, the following flavonoid structure-activity relationships became apparent. 1)Flavonoids with C2-3 double bond in C-ring were more active than that of C2-3 saturation. 2)Flavonoids with C4 ketone group in C-ring were more active than absence of them except catechin and malvin. 3)Flavonoids with benzene ring at positions 2 or 3 in C-ring exhibited same activities. 4)Flavonoids with opening of the C-ring does not abolish their activities. 5)The glycosylated flavonoids in position 3 or 7 was less active than their aglycone. 6)Flavonoids with the more hydroxy group in A and B-ring were more active. 7)Flavonoids with or without C3-OH did not change their activities.
식물성생리활성물질의 간보호작용(Ⅰ). : 한약처방의 간보호작용
김창종(Chang Johng Kim),조승길(Seung Kil Cho),최충식(Chung Sik Choi),최윤석(Yun Suk Choi) 한국생약학회 1990 생약학회지 Vol.21 No.3
Hepatoprotective activities of 26 traditional Korean herbal prescriptions described in Donghibogam were evaluated in vivo and in vitro screening system. Twenty one prescriptions appeared to be active. Six prescriptions among them showed highly significant hepatoprotective activities; Shihogyegy-Tang(柴胡桂枝湯), Soshiho-Tang(小柴胡湯), Shiho plus Younggolmoryo-Tang(柴胡加龍骨牡蠣湯), Yinjinho-Tang(茵蔯蒿湯), Yinsam-Tang(人蔘湯) and Shashim-Tang(瀉心湯). Shihogyegy-Tang was most active. They reduced the release of transaminases from dissociated hepatocytes by thioacetamide, and serum transaminases and alkaline phosphatase activities of rat with carbontetrachloride-induced hepatitis. They inhibited significantly lipid peroxidation and cellular fatty change of liver by carbontetrachloride.
Flavonoids의 약리작용(II) -항염작용과 창상치유 억제작용과의 상관성-
김창종(Chang Johng Kim),서수경(Soo Kyung Su),주재현(Jae Hyun Joo),조승길(Seung Kil Cho) 대한약학회 1990 약학회지 Vol.34 No.6
The relationships of inhibitory activities of inflammation and wound healing of flavonoids were studied in vitro and in vivo. Generally flavonoids have not only significantly anti-inflammatory activity in carrageenin-induced paw edema and Freund''s complete adjuvant-induced arthritis, but also inhibitory activity of wound healing. The more inhibitory activities Of wound healing flavonoids have. the more they have the anti-inflammatory activities; apigenin > guercetin > flovone > rutin > hesperidin > naringin. Their inhibitory mechanism seems to be inhibition of the inflammatory cell infiltration and fibroblast proliferation, and so they decreased the granulomatous activity and tensile strength.
동물성 소염진통제(II) -반묘 및 먹가래 다당체분획의 소염, 진통 및 면역조절작용-
김창종(Chang Johng Kim),최충식(Choong Sik Choi),조승길(Seung Kil Cho) 대한약학회 1991 약학회지 Vol.35 No.5
Effect of Mylabris sidae(MS) and Epicauta gorhami(EG) polysaccharide fractions on the inflammation and immune responses were studied in vivo. MS and EG contained cantharidin about 0.61 and 0.65%, respectively. It was shown that MS and EG polysaccharide fractions at a oral dose of 100 mg/kg have the significant anti-inflammatory and analgesic activity; They inhibited significantly the carrageenin-induced inflammation and acetic acid-induced writhing syndrome. They accelerated significantly the carbon clearance and the phagocytosis of colloidal carbons by Kupffer cells in liver, but they at a oral dose of 100 mg/kg suppressed significantly the Arthus reaction in the sheep red blood cell(S-RBC)-sensitized mice in accordance with the inhibition of haemaglutinin titer, haemolysin titer and plaque-forming cells. On the other hand, they at a oral dose of 200 mg/kg accelerated slightly the oxazolone-induced dermatitis in rats and delayed hypersensitivity in the S-RBC-challenzed mice in consistent with the increase of rosette forming cells. As the above results, it exhibited that MS and EG polysaccharide fractions inhibited the humoral immune responses, but they accelerated the function of macrophages and cellular immune responses. EG polysaccharide fraction had more active than MS polysaccharide fraction.
Flavonoids의 약리작용(IV) - 백혈구유주, superoxide anion 및 과산화지질 생성 억제작용 -
김창종(Chang Johng Kim),정현삼(Hyun Sam Jung),정진모(Jin Mo Chung) 대한약학회 1991 약학회지 Vol.35 No.3
Effects of eight flavonoids and their related compounds on leukocytes migration, superoxide anion production and lipid peroxidation in the phagocytosis of latex beads or E. coli by guinea pig peritoneal exudate cells were studied in vitro. It shows that most of flavonoids generally inhibited the leukocytes migration and production of superoxide anion and malonedialdehydes. Their inhibitory activities in the phagocytosis of latex beads had more active than that of E. coli. Quercetin has the most inhibitory activity in leukocytes migration and production of superoxide anion and lipid peroxides at the concentration of 1, 2 and 10 mcM. Catechin and rutin at the concentration of 2 and 10 mcM inhibited significantly the production of superoxide anion and lipid peroxides. Flavone, catechin, naringin and rutin at the concentration of 2 and 10 mcM inhibited significantly the leukocytes migration.
육창수(Chang Soo Yook),김선창(Sun Chang Kim),김창종(Chang Johng Kim),한덕룡(Dug Ryong Han) 대한약학회 1991 약학회지 Vol.35 No.3
Chemical constituents of fruits, leaves and barks of Acanthopanax senticosus forma inermis were studied. Their fruits have higher contents of crude ash, crude protein, crude fat, fructose and glucose than those of other Acanthopanax species, and contained larger amount of glutamic acid and malic acid among amino acid and organic acid, respectively. The compounds identified from their barks and leaves, were beta-sitosterol and stigmasterol, sesamin, savinin, syringaresinol diglucoside, oleanolic acid, chiisanoside and polyacetylene (C9H10O2, mp. 62-63).