인터뷰 - 김지혜 롯데칠성음료(주) 디자인팀 디자이너

김지혜,Kim, Ji-Hye (사)한국포장협회 2010 包裝界 Vol.210 No.-

지식경제부와 한국디자인진흥원은 대한민국 디자인 산업을 이끌어갈 우수한 신예 디자이너 발굴의 장이자, 국내 산업 디자인의 미래를 조망하는 "대한민국디자인전람회" 수상작을 발표했다. 대한민국 디자인계를 이끄는 학계 산업계의 초대 추천 디자이너 542명을 배출한 이 전람회는 1995년부터 집계된 출품 수만 2만5천여 점에 달하는 국내 최대 최고 규모의 공모전이다. 이번 전람회에서는 롯데칠성 디자인팀의 김지혜 씨가 바쁜 현대인들에게 안전하고 건강한 생활 식습관을 제안한 "요리하는 즐거움, 건강한 라이프스타일을 위한 패키지디자인연구"로 국무총리상을 수상하게 됐다. 김지혜 디자이너에게 작품 소개 및 패키지디자인에 대한 견해를 들어보았다.

In Vivo Angiogenic Capacity of Stem Cells from Human Exfoliated Deciduous Teeth with Human Umbilical Vein Endothelial Cells

김지혜,남현,김지혜,김재원,편희장,이재천,이진 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.11

Dental pulp is a highly vascularized tissue requiring ade-quate blood supply for successful regeneration. In this study, we investigated the functional role of stem cells from human exfoliated deciduous teeth (SHEDs) as a perivascular source for in vivo formation of vessel-like structures. Primarily isolated SHEDs showed mesenchymal stem cell (MSC)-like characteristics including the expression of surface antigens and in vitro osteogenic and adipogenic differentiation potentials. Moreover, SHEDs were positive for NG2, -smooth muscle actin (SMA), platelet-derived growth factor receptor beta (PDGFR), and CD146 as pericyte markers. To prove feasibility of SHEDs as perivascular source, SHEDs were transplanted into immunodeficient mouse using Matrigel with or without human umbilical vein endothelial cells (HUVECs). Transplantation of SHEDs alone or HUVECs alone resulted in no formation of vessel-like structures with enough red blood cells. However, when SHEDs and HUVECs were transplanted together, extensive vessel-like structures were formed. The presence of murine erythrocytes within lumens sug-gested the formation of anastomoses between newly formed vessel-like structures in Matrigel plug and the host circulatory system. To understand underlying mechanisms of in vivo angiogenesis, the expression of angiogenic cytokine and chemokine, their receptors, and MMPs was compared between SHEDs and HUVECs. SHEDs showed higher expression of VEGF, SDF-1, and PDGFRthan HUVECs. On the contrary, HUVECs showed higher ex-pression of VEGF receptors, CXCR4, and PDGF-BB than SHEDs. This differential expression pattern suggested reciprocal interactions between SHEDs and HUVECs and their involvement during in vivo angiogenesis. In conclusion, SHEDs could be a feasible source of perivascular cells for in vivo angiogenesis.

The Stress-Reducing Effects of Forest Healing Activities in Maladjusted Military Force Members

김지혜,신창섭,김지혜,김도형,김윤수,이현채 인간식물환경학회 2020 인간식물환경학회지 Vol.23 No.3

Background and objective: In the Republic of Korea, military service is mandatory. Some of new recruits have the stress from the special environment, which could cause psychological maladjustment. The military forces have operated education programs such as green camp and healing camp. The study was conducted to investigate changes in psychological and physiological stress by conducting forest healing activities along with plant scent treatment for soldiers participating in a green camp. Methods: A total of 52 soldiers were participated including maladjustment soldiers and those recommended by their military units to protect the unfit soldiers who participated in forest healing activities in the green camp. The programs that were certified by the Korea Forest Service between 2014 and 2019, and were applied for stress reduction and relaxation training were classified into stress-coping programs and forest experience programs. Post-hoc surveys and cortisol measurements were carried out. Results: Green camp soldiers experience and differences in the level of stress responses were found to be very statistically significant between the treatment and control groups. The techniques for coping with stress were not significantly different in the control group, and the treatment group showed statistically significant results. In addition, the results of analyzing changes in the concentration of cortisol and measuring physiological stress were very statistically significant in forest healing activities at 4 p.m. Conclusion: Once green camp soldiers face stressful situations, forest healing programs using forest plant scents for green camp soldiers can have positive responses and forest healing activities can reduce psychological and physiological stress responses, improving maladjustment behaviors caused by stress and positively affecting the reduction of cortisol.

성소수자 아동청소년을 위한 포용적 교육

김지혜 한국사회과학연구회 2016 동향과 전망 Vol.- No.96

This article argues that the principle of inclusive education is supported by the right to education enshrined in the Constitution of the Republic of Korea as well as international human rights laws, and that it should be incorporated in education policy in relation to LGBTI children and youth in the Republic of Korea. Inclusive education, as a concept used in the international context, emphasizes the realization of the right to education for all, embracing diversity of human beings. In contrast to the fact that gender and sexual diversity in human beings has come to be recognized over time in the history, however, the prevailing phenomenon in Korea is that LGBTI children and youth in Korea are largely invisible in schools, reflecting the reality that they are widely oppressed and marginalized in the school environments. This article thus proposes that the government adopt policies for LGBTI children and youth under the principle of inclusive education, while addressing the problem of religious interference with education policy of some Christian groups that goes against the principle of pluralism and the principle of religious impartiality in education under the Constitution. 이 글은 성소수자 아동청소년을 위한 ‘포용적 교육(inclusive education)’이 헌법상 기본권이자 인권인 교육권의 보장을 위해 규범적으로 요청된다고 논하며, 이를 교육의 원칙이자 정책으로 삼아야 한다고 주장한다. 포용적 교육은 모든 사람이 향유하여야 할 권리인 교육받을 권리를 실현하기 위한 원칙이자 분석틀로서 국제사회에서 등장한 개념으로서, 교육이 다양성의 이해와 존중, 관용의 증진, 민주시민의 양성이라는 본래의 목적을 달성하도록 정책 개선의 방향을 제시하는 유용한 관점을 제공한다. 이러한 포용적 교육 속에 성소수자 아동청소년이 고려되는 것은 인간의 성적 다양성을 발견하여 온 역사적 맥락 속에서 자연스러운 귀결이지만, 이러한 이해가 결여된 한국의 교육환경에서 성소수자 아동청소년은 비가시성으로 대표되는 배제의 상태에 놓여 있다고 본다. 이에 이 글에서는 한국에서 성소수자 아동청소년을 위한 포용적 교육을 실천하기 위한 접근을 제안하는 한편, 교육정책에서 성소수자 아동청소년과 관련하여 특정 종교적 교리에 기초한 불관용의 입장을 수용하는 것이 교육의 종교적 중립성 원칙과 다원주의적 교육원칙에 위배되는 문제를 지적한다.

파킨슨 경도인지장애와 피질하 혈관성 경도인지장애의 인지기능의 비교

김지혜,진영선,장문선,최소영,권오대 대한신경과학회 2011 대한신경과학회지 Vol.29 No.3

Background: Patients with Parkinson’s disease and mild cognitive impairment (PD-MCI) and patients with subcortical vascular mild cognitive impairment (svMCI) are known to have cognitive dysfunction. The aim of this study was to determine the cognitive characteristics that can be used to differentiate these two conditions. Methods: Twenty-two PD-MCI and 22 svMCI patients seen in our neurodegenerative disease clinic, and 22 normal controls were recruited. These three groups were matched in terms of age, gender, and education level. Mild cognitive impairment was diagnosed according to the criteria of Petersen. svMCI should meet the criteria modified from those of Erkinjuntti. Results: Analysis of covariance revealed that frontal executive dysfunction was prominent in both the PD-MCI and svMCI groups after adjusting for depression. The scores in word fluency and the Stroop test were lower in the svMCI group than in the PD-MCI group. Both groups exhibited decreased performance in verbal and visuospatial memory tests. The score in the verbal recognition test was lower in the PD-MCI group than in the svMCI group, which exhibited comparatively reduced visuospatial memory. The depression level was higher in the PD-MCI group than in the svMCI group, as assessed using the Geriatric Depression Scale. Conclusions: The impairment in frontal executive function was more severe in the svMCI group than in the PD-MCI group, which displayed severe impairment in verbal memory function. These differences in cognitive function may help to differentiate PD-MCI from svMCI, and to further the understanding of their pathophysiologies. PD-MCI patients also exhibited severe depressive mood, which raises the possibility of cognitive improvement through therapy. Background: Patients with Parkinson’s disease and mild cognitive impairment (PD-MCI) and patients with subcortical vascular mild cognitive impairment (svMCI) are known to have cognitive dysfunction. The aim of this study was to determine the cognitive characteristics that can be used to differentiate these two conditions. Methods: Twenty-two PD-MCI and 22 svMCI patients seen in our neurodegenerative disease clinic, and 22 normal controls were recruited. These three groups were matched in terms of age, gender, and education level. Mild cognitive impairment was diagnosed according to the criteria of Petersen. svMCI should meet the criteria modified from those of Erkinjuntti. Results: Analysis of covariance revealed that frontal executive dysfunction was prominent in both the PD-MCI and svMCI groups after adjusting for depression. The scores in word fluency and the Stroop test were lower in the svMCI group than in the PD-MCI group. Both groups exhibited decreased performance in verbal and visuospatial memory tests. The score in the verbal recognition test was lower in the PD-MCI group than in the svMCI group, which exhibited comparatively reduced visuospatial memory. The depression level was higher in the PD-MCI group than in the svMCI group, as assessed using the Geriatric Depression Scale. Conclusions: The impairment in frontal executive function was more severe in the svMCI group than in the PD-MCI group, which displayed severe impairment in verbal memory function. These differences in cognitive function may help to differentiate PD-MCI from svMCI, and to further the understanding of their pathophysiologies. PD-MCI patients also exhibited severe depressive mood, which raises the possibility of cognitive improvement through therapy.

신생아 중환자실을 퇴원하는 고위험 환아에서 순차적인 뇌초음파 검사 후 시행한 자기 공명 영상의 유용성

김지혜 대한자기공명의과학회 2008 Investigative Magnetic Resonance Imaging Vol.12 No.2

목적 : 순차적인 뇌초음파 검사 후 신생아 중환자실을 퇴원하는 고위험 환아에서 시행한 자기 공명 영상의 유용성을 알아보고자 하였다. 대상 및 방법 : 총 121명의 신생아에서 시행한 412 초음파와 121 자기공명 영상을 후향적으로 분석하여 초음파 검사에서 발견된 뇌병변과 자기 공명영상에서 발견된 병변을 비교하였다. 뇌병변은 배아기질 출혈 및 뇌실 내 출혈, 그 밖의 여러 출혈과 뇌실질 손상을 중심으로 비교 분석하였다. 결과 : 총 242개의 측뇌실 중 30뇌실의 배아기질 출혈 (GMH)을 초음파로 진단하였고 자기공명영상으로 7개의 GMH를 추가로 진단할 수 있었으며 46개 뇌실의 출혈 (IVH)을 추가로 진단하였다. 출혈의 1/2/3/4 등급은 초음파에서 각각 24/8/13/0 뇌실에서 진단하였고 자기공명영상에서 3/49/10/2 뇌실에서 진단하였다. 그 외에 자기공명영상에서 대뇌 출혈 (4예), 소뇌 출혈(4예), 경막하 및 지주막하 출혈 (8예), 미만성 백질 신호강도 변화 (72예), 조직손실이 없는 작은 실질 병변 (4예), 뇌연화증 (2예), 그리고 뇌실확장 (5예)이 추가로 발견되었다. 결론 : 자기공명영상은 초음파 검사 후 두개강내 출혈과 뇌실질 손상을 추가적으로 진단하는 유용한 검사였으며 특히 뇌실 출혈과 백질 손상의 진단에 우수한 반면 배아기질 출혈은 초음파 추적검사가 더 유용할 것으로 생각한다.

기억력 저하를 호소하는 노인들을 대상으로 INM176를 3개월간 임상시험한 후의 치료성적 및 부작용 평가 보고

김지혜,고선규,고효정,권영아,김성환,김재경,김태은,박재우,서민영,송영란,이인수,김도관 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.2

Objectives : We examined the effects of INM 176 (K-l107) compared with placebo on the cognitive functions of 92 old aged subjects with cognitive impairment. Methods : This was a prospective, 12 week, double-blind, Placebo-controlled clinical trial. The elderly who achieved a score of less than 25 points on the K-MMSE or showed a high risk of Alzheimer's disease from the 7-Minute Neurocognitive Screening Battery were considered to have objective impairment and were selected as subjects for this study. The subjects were randomized to placebo or INM 176 group. The outcome measures were from the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog), the Instrumental Activities ofDaily Living (IADL) and the Korean Geriatric Depression Scale (KGDS) and two kinds of computerized priming tests. After setting the total error score in the Alzheimer's Disease Assessment Scale-Cognitive section (ADAS-cog) as the repeated measurement factor, an analysis of variance of the combined factor design was done between the placebo and INM 176 group. Results : The interaction effect of time (pre- and post-trial) and group (placebo and INM 176 group) was significant in the analysis of the ADAS-cog's total error score. The INM 176 group's total error score in the ADAS-cog decreased significantly (p<0.01), whereas the placebo group showed a slight increase. The mean changes in IADL and GDS from baseline scores favored in the INM 176 group than in the placebo group. Outcome changes ofADAS-cog, IADL, KGDS scores during the 12 week clinical trail ofINM 176 and placebo demonstrated favorable responses in the INM176 administered group. Conclusions : This is a preliminary clinical trial result of INM176 as a memory pill. Based on these results, INM176 may be a candidate molecule for the improvement of cognitive functions, including memory, Further clinical trial should demonstrate its efficacy.

모리악의 전반기 저널리즘에 나타난 정치적 입장 : 저널리스트와 소설가 사이의 사상적 모순 la contradiction des idees entre le journaliste et le romancier

김지혜 한국불어불문학회 1999 佛語佛文學硏究 Vol.38 No.1

Au de´but de son activite´ journalistique, alors qu'il coilabore aux journaux tels que Le Journal de Clichy(1914-jusqu'au de´but de la guerre) et Le Gaulois(1919-1921), les analyses de Mauriac sur les proble`mes d'actualite´ sont celles d'un bourgois conservateur et chre´tien, d'un homme de droite : il re´agit contre la gre`ve, contre la C.G.T. et contre la politique radicale du gouvernement et il est de´favorable au syste`me parlementaire. Entre 1932 et 1934, pendant qu'il est a` L'Echo de Paris, la vision de Mauriac est toujours rattache´e a` la pense´e bourgeoise. Ses chroniques de´noncent la franc-mac¿onnerie, il y re´clame un homme d'autorite´, capable de ≪nettoyer l'Etat≫ face aux politiciens de gauche incapables de re´soudre les proble`mes internes et externes du pays et de cre´er un climat de stabilite´, de l'ordre. Il proteste contre les intellecteuls de gauche qui se sont rallie´s a` l'ide´ologie communiste. Ses articles traduisent alors la position de l'homme de droite, me^me d'extre^me-droite qui souhaite l'ave`nement d'une droite muscle´e avec exe´cutif fort. En revanche, Mauriac rornancier de´nonce, dans une peinture vive de la socie´te´ bourgeoise ou` il est ne´ et ou` il a ve´cu, le conservatisme, le pharisai¨sme et le conformisme social, moral et politique caracte´risant l'esprit bourgeois. A propos de ses critiques de la bourgeoisie e´goi¨ste et pourrie, le romancier commente lui-me^me que ce n'est pas pour montrer que seule la classe bourgeoise est le lieu de la corruption mais c'est pluto^t pour traduire l'e´goi¨sme des e^tres humains et les conflits que cela implique, et que pour nourrir son histoire romanesque, 'il choisit tout simplement ≪des hommes et des femmes tels qu'ils [lui] sont apparus dans le monde ou` [il est] ne´≫. De toutes fac¿ons, il est vrai que le romancier de´passe l'ide´ologie conservatrice de sa classe et de´peint la socie´te´ bourgeoise d'un point de vue objectif ou bien moins limite´ que celui de journaliste. Quand on rappelle ses positions politiques qui se rattachent aux valeurs et aux ide´ologies conservatrices de son milieu natal et de ses jouranux collabore´s, on peut donc dire qu'il existe une certaine contradiction entre la vision de romancier et celle de journaliste.

집으로 가는 길: 형제복지원 그 후

김지혜 한국인권학회 2018 인권연구 Vol.1 No.2

아르헨티나 동포 친구에게

김지혜 한국국어교육학회 2000 세계가 한동네 Vol.2000 No.-