21세기를 향하는 광전자기술 동향

권오대 대한전자공학회 1995 대한전자공학회 학술대회 Vol.1995 No.1

Apolipoprotein E4: A Risk Factor for Successful Cognitive Aging

권오대 대한치매학회 2016 Dementia and Neurocognitive Disorders Vol.15 No.3

Apolipoprotein E is a plasma protein that has an important role in transport and metabolism of lipids in serum as well as central nervous system. Among the 3 common alleles, the ε2 allele has the most stable structure followed by ε3 and ε4 in order. There is evidence for a deleteriousrole of ε4 allele by atherosclerosis and amyloid beta accumulation in brain and body. The presence and gene dose of ε4 allele are risk factors forlate-onset Alzheimer’s disease. Apolipoprotein E ε4 may have a role in the pathology of amyloid beta and tau and it has a strong relationshipwith the early onset of late-onset Alzheimer’s disease. However, early-onset Alzheimer’s disease has a weaker relationship with ε4 allele of apolipoproteinE.

Association of head circumference with cognitive decline and symptoms of depression in elderly: a 3-year prospective study

권오대,최소영,배지숙 영남대학교 의과대학 2018 Yeungnam University Journal of Medicine Vol.35 No.2

Background: Brain volume is associated with dementia and depression in the elderly. An easy way to predict relative brain volume is to measure head circumference. In this study, we investigated the relationship between head circumference and cognition as well as depression in a non-demented elderly community. Methods: Baseline and follow-up surveys were conducted in 2007 and 2010. At baseline, community residents aged 65 years or over (n=382) within a rural area of South Korea were screened for dementia and symptoms of depression and were followed using the same screening battery after 3 years (n=279). Data from anthropometric measurements (head circumference, height, and body weight), demographics, and blood tests were gathered. Neuropsychological tests, including the Korean version of mini-mental state examination (K-MMSE), clinical dementia rating (CDR) including the CDR-sum of boxes, the Korean version of instrumental activities of daily living, and geriatric depression scale (GDS), were performed. None of the 279 subjects followed were demented. Results: Baseline performance on the K-MMSE and GDS was poorer for participants with smaller head circumferences. Follow-up performance on the MMSE was also poorer for participants with smaller head circumferences. Interestingly, participants with smaller head circumference showed worse GDS scores at baseline but on follow-up examination, participants with larger head circumference showed rapid worsening than those with smaller head circumference with marginal significance by ANOVA test. In regression coefficient analysis, GDS decline showed significant difference. Conclusion: Head circumference was not associated with cognitive change but was associated with symptoms of depression in non-demented community residents.

신소재 연구동향

권오대 대한전자공학회 1990 대한전자공학회 워크샵 Vol.1990 No.-

Effect of Gongjindan, a Traditional Korean Polyherbal Formula, on the Pharmacokinetics Profiles of Donepezil in Male SDRats (2) ― Single Oral Combination Treatment of Donepezil 10mg/kg with Gongjindan 100mg/kg, 1.5hr-intervals with 7-day Repeated Treatm

권오대,구세광,이영준,정대규,박수진 대한예방한의학회 2013 대한예방한의학회지 Vol.17 No.2

Purpose : This study was aim to evaluate effects of pharmacodynamics and toxicity in combination therapy of donepezil with Gongjindan. The effects of Gongjindan co-administration on the pharmacokinetics (PK) of donepezil were observed after single and 7-day repeated oral co-administration with 1.5hr-intervals, to evaluate synergic pharmacodynamics and reduce toxicity of combination therapy of donepezil with Gongjindan. Materials and Methods : After 10mg/kg of donepezil treatment, Gongjindan100mg/kg was administered with 1.5hr-intervals. The plasma were collected at 30min before administration, 30min, 1, 2, 3, 4, 6, 8 and 24hrs after end of first and last 7th donepezil treatment, and plasma concentrations of donepezil were analyzed using LC-MS/MS methods. Results : Gongjindan markedly inhibited the absorption of donepezilregardless of sample time, from 30min to 8hrs after end of first 1.5hr-interval co-administration as compared with donepezil single treated rats. Especially the absorption of donepezil was significantly decreased at 2, 4, 6 and 8hrs after co-administration as compared with donepezilsingle treated rats. Accordingly, the Cmax (-26.236%), tex:\small\textstyle$AUC_{0-t}$(-26.02%) and tex:\small\textstyle$AUC_{0-inf}$(-25.90%) of donepezil in 1.5hr-interval co-administered rats were dramatically decreased as compared with donepezilsingle treated rats, respectively. However, no meaningful changes on the plasma donepezil concentrations and pharmacokinetic parameters were detected after end of last 7th 1.5hr-interval co-administration as compared with donerezil single treated rats, except for non-significant slight increases of Tmax(16.67%) detected in co-administered rats as compared with donepezil single treated rats. Conclusion : These findings are considered as direct evidences that Gongjindan also decreased oral bioavailability of donerezil as inhibited the absorptions, when they were co-administered with 1.5hr-intervals, but they may be adapted after 7 days continuous repeated l.5hr-interval co-administration.

안구운동마비를 동반한 접형동 아스페르길루스증

권오대,배종엽 대한신경과학회 2005 대한신경과학회지 Vol.23 No.4

Ophthalmoplegia due to spheniod sinus aspergillosis is rare. We report two cases of sphenoid sinus aspergillosis with diplopia. A diabetic patient presented with complete oculomotor nerve palsy and showed more rapid progression, severe symptoms, and delayed and incomplete recovery from the neurologic deficits. The other patient presented with trochlear nerve palsy and showed slower progression milder symptoms, and more rapid recovery. We suggest that immediate imaging should be performed to diagnose the cause of diplopia in patients with atypical unilateral persistent facial pain with diplopia especially in patients with diabetes mellitus.

F-18 FDG-PET을 이용한 고압전기손상 후에 발생한 인지기능 장애의 추적 연구

권오대,곽재혁,박재한 대한신경과학회 2007 대한신경과학회지 Vol.25 No.4

We report a 43-year-old male who suffered cognitive dysfunction after an electric injury. He underwent evaluation for cognitive dysfunction and cerebral glucose hypometabolism at 1 week and 6 months. In contrast to the progressive decline of frontal lobe functions and visuospatial functions, memory and depressive mood were improved. SPM99 showed hypometabolic areas in the frontal and occipital lobes which were widened. Moreover new cingulate lesions appeared. This illustrates that the progression of derangement of cerebral glucose metabolism is correlated with neuropsychological impairment. KeyWords:Electric injuries, Neuropsychology, Positron-emission tomography

알츠하이머병에서 동시에 증상이 나타난Pisa 증후군과 정상압 수두증

권오대 대한신경과학회 2008 대한신경과학회지 Vol.26 No.1

Extrapyramidal symptoms are common in patients with advanced Alzheimer’s disease and have various etiologies. We report a 65-year-old man with probable Alzheimer’s disease (AD) who concomitantly developed Pisa syndrome, ataxic gait, postural instability and voiding difficulty. Pisa syndrome improved after the discontinuation of acetylcholinesterase inhibitor (AchEI) and antipsychotics. However his ataxic gait and voiding symptoms persisted. A ventriculo-peritoneal shunt operation eliminated the symptoms except for cognition. We report Pisa syndrome in a patient with Alzheimer’s disease and concomitant normal pressure hydrocephalus.

Effect of Illiteracy on Cognition and Cerebral Morphology in Later Life

권오대,윤의철,Duk L. Na 대한치매학회 2015 Dementia and Neurocognitive Disorders Vol.14 No.4

Background and Purpose A better developmental environment has positive effects on brain development. The acquisition of literacyduring childhood may affect brain functional organization. The present study aimed to evaluate the effects of illiteracy on neuropsychologicaltest results and cerebral morphology in later life. Methods We recruited 7 illiterate elderly farmers who had never attended school and had no reading or writing knowledge. These subjectswere compared with 9 literate subjects in terms of neuropsychological performance and brain volume. All subjects were over 65-years-oldand had the same regional and occupational background. Results Neuropsychological tests indicated that the performance of the illiterate subjects was worse than that of literate subjects in all cognitivedomains except forward digit span, tool-use and tool-free gestures, verbal word recognition, and verbal generation of animals and groceryitems. The illiterate group also showed significantly decreased cortical volume and surface area in both parietal lobes. However, the illiterategroup showed increased cortical thickness in the left cuneus. Conclusions Literacy acquired in childhood may increase the volume of the parietal lobe and improve neuropsychological performancethrough the process of brain plasticity. The effects can be lifelong.

광교환 분야

권오대 한국통신학회 1997 한국통신학회 기타 간행물 Vol.- No.-