Q - switched Nd ; TAG 레이저를 이용한 오타 모반의 치료 효과

김중기 ( Joong Gie Kim ),김균태 ( Kyun Tae Kim ),남인환 ( In Whan Nam ),안성구 ( Sung Ku Ahn ) 대한피부과학회 1995 大韓皮膚科學會誌 Vol.33 No.4

Background : The nevus of Ota is a benign dermal melanocytic lesion that was previously proved difficult to treat. Recently, the Q-switched ruby laser and Q-switched Nd: YAG laser have been reported to by, successful in the treatment of benign pigmented lesions and tattos. Objective : Our study evaluates the treatment of 60 patients with nevus of Ota with Q-switched Nd: YAG lase (l064nm). Method : Sixty patients with nevus of Ota were treated by the Q-switched Nd: YAG laser with pulse width 10nsec, and energy fluences ranging from 5.8 to 12J/cm and the laser repetition rate was 5 or 10Hz. The response to treatment was assessed by four independent investigators with photographs. Results : 1. Total therapeutic effects of Q-switched Nd: YAG laser showed excellent result in 23.3%, good in 45%, fair in 18,3%, and poor in 13.3%. 2. Therapeutic effects by distribution proposed by Tanino showed excellent or good results in 84.6% at type Ia, 78.6% at, type Ib, 66.7% at type II, 60% at type III and 45.5% at type N. 3. Therapeutic effects by the number of treatments showed excellent or good results in 22.2% of patients after one treatment, 72.7% after two treatments, 93.3% after three treatments and 100% after four treatment. 4. Therapeutic effects by energy showed excellent or good results in 9.2% at energy range of 10 to 12J/arl and 66.6%, at energy range of 5.8-9.5J/cm. 5. Complications included transient hyperpigmentation (6.7% ), secondary bacterial infection (1.7 %), hypopigmentation (1.7%) and atrophic scar (1.7%). However these subsided spontaneously in a year. 6. The recurrence rate was 2.4%. Conclusion : The Q-switc:hed Nd: YAG laser is a very effective mode of treatment for nevus of Ota which has provent unresponsive to other therapeutic modalities. (Kor J Dermatol 1995;33(4): 686-692)

구리 증기 레이저 치료후 화염상 모반의 병리조직학적 소견

정준(Joon Chung),남인환(In Whan Nam),김중기(Joong Gie Kim),안성구(Sung Ku Ahn),이승헌(Seung Hun Lee) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.4

Nevus flammeus is a benign but cosmetically devascating congenital inalformation involving mature capillaries. The copper vapor laser is a therapeutic device which had been newly applied to this. Yellow copper vapor light is absorbed by the intraluminal oxyhemoglobulin mo ecules, leading to the destruction of blood vessels. This study was undertaken to evaluate the histobigic findings in a patient with nevus flammeus according to the sequential time after copper vapor laser therapy. The results were as followed, One hour after treatment, nonspecific damages to the epidermis and upper part of the dermis were observed. The specific damage to the vessels which showed thrombi formations and partial disruption of the vessel walls was prominent. One cay after treatment, degeneration of the epidermis and sepaiation of the dermoepidermal junction were apparent. Three days after treatment, extravasations of a small amount of erythrocytes and inflanimatory cell infiltrations were present, especially around the vessels. Seven days after treatment, the capillaries showed a deposition of fiorinoid material around themselves. Partial disappearance of the vessel walls was seen. There was hisi ologic evidence of the replacement of abnormal ectatic vessels by normal appearing vessels with small uminal diameters, surrounded by endothelial cells. (Kor J Dertnatol 1993;3(4):598-600)

Carbon Dioxide Laser Vaporization으로 치료한 외음부의 림프관 확장증 ( 후천성 림프관종 )

남인환,허원,안성구,이승헌,강원형,김중기 ( In Whan Nam,Won Hur,Sung Ku Ahn,Seung Hun Lee,Won Hyoung Kang,Joong Gie Kim ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.6

Lymphangiectasia(acquired lymphangioma) represents acquired dilatations of lymphatics which closely resemble congenital lymphangioma clinically and his opathologically. This rare disorder may arise as a result of aquired lymphatic obstruction secondary to surgery, irradiation, chronic scar, or trauma. We present herein a case of lymphangiectasia in a 43-year-old female on a postirradiation site. She developed grouped tense oozing vesicles on the vulva, 8 years after total abdominal hysterectomy and postoperative irradiation for carcinoma of the uterine cervix. Laser therapy with the carbon doioxide laser was performed.

탄산가스 레이저로 치료한 면포성 모반

남인환(In Whan Nam),김영호(Young Ho Kim),김중기(Joong Gie Kim),박장규(Jang Kyu Park) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.2

At twenty two year old female with nevus comedonicus and an increased tendency to form keloids is described. Although example of successful treatment of nevus comedonicus are readily found in the literature none propose reasonable therapeutic models for keloid formers. As our patient clearly demonstrated this tendency. We initated a t,rial with the carbon dioxide laser due to it's ability to cause less thermal damage. Subsequent to completion of this t,rial, the lesion has imprcived with the acceptable cosmetic results and less comedogenic activity. (Kor J Dermatol 1992;30(2): 221-224)

탄산가스 ( CO2 ) 레이저와 구리증기 ( copper vapor ) 레이저를 이용한 혈관 섬유종의 치료

남인환(In Whan Nam),허원(Won Hur),안성구(Sung Ku Ahn),김중기(Joong Gie Kim) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.4

Angiofibroma is a disfiguring facial deformity that constitutes pait of the multiple system involvement in tuberous sclerosis. We describe eight affected patients who have been treated with:arbon dioxide laserabration and subsequent copper vapor later treatment for residual angiomatous component, which resulted in conspicious cosmetic improvement without scarring or recurrence. This report documents that the treatment with carbon dioxide later and subsequent copper vapor laser is an efficient and safe remedy for treating multiple facial angioibromas. (Kor J Dermatol 1993;31(4):590-595)

Vitamin A acid 유도체 국소도포에 의한 좌창치료의 임상적 연구

김중기,이성낙 대한피부과학회 1977 大韓皮膚科學會誌 Vol.15 No.4

Although many regimens for the acne therapy were proposed and vere used upto date, there is, no ideal choice of treatment. Since a certain relationship between the vitamin A and some dermatoses accompanied, with dyskeratoses had been proposed by Harris in 1932. many studies have been reported for the acne treatment with vitamin A topical or oral administration. (Straumfjord 1943, Lynch & Cook 1947, Anderson & Stokoe 1968). In 1969, Kligman observed the peeling effect of vitamin A acid (VAA), a metabolite of vitamin A, on the human skin and he experienced very good effect of VAA topical application on acne patients. Thereafter, many authors studied about the VAA and reported the excellent effect on acne (McGills et al. 197l, Mills R Plewig 1972, Juhlin 1975). Moxeover, in 1976, Kim & Lee observed similar results with the authors mentioned above in its cure rate and side effects. In contrast to their high cure rate in those studies, however, its untoward side effects were freqvently elicited with severe intensity. So, author studied the effectiveness and side effects of VAAD which was changed in its chemical structure to diminish the side effects of VAA. Thirty-seven patients (M:F=4:33) were studied, and the results obtained were as follows. 1. The total number of lesions decreased significantly from third week and decreased by half in 4th. week. 2. The number of closed comedones decreased significantly from second week but the number of open comedones temporarily increased in 1st. week and decreased thereafter. 3. pustules and papul s continually decreased but new pustule formation developed in 3 patients and also disappeared in 4 weeks of treatment. 4. Allergic contact dermatitis was developed in 1 patient among 37 patients in 4th. week. 5. There were some undesirable side effects of scaling, pruritus, buming sensation in about 80% respectively, but its intensity was mild or moderate, and fissure, edema and exudation which appeared in VAA treatment were not observed. only a few patients complained tightness, erythema and pain. In comparison with VAA, the duration of treatment with VAAD was delayed about 1-2 weeks and the effectiveness in acne therapy with VAAD was almost equal to VAA therapy, and the side effects were markedly diminished.

매독의 진단

김중기,이성낙 대한의학협회 1976 대한의학협회지 Vol.19 No.10

항 히스타민제 및 dexamethasone이 히스타민 유발 장관수축에 미치는 영향

金重基,李成洛,安英秀,金源准 연세대학교 의과대학 1982 연세의대논문집 Vol.15 No.2

비색소성 흑색종의 1 예

진홍상,김중기,조정구 대한피부과학회 1977 大韓皮膚科學會誌 Vol.15 No.4

A case of amelanotic melanoma developed on a 19 years old boy was reported. Since the identification of amelanotic melanoma, there were few reports about the tumor but none in Korea. In this case, the histologic findings showed ulceration of the epidermis and irregular junctional activity, and in the dermis, there showed alveolar formation and nevus cell nest like cell masses. And in the deep dermis, the loss of dermal stroma with numerous bizzare giant cells and variable sized, hyperchromatic, plemorphic, mitotic figures were also seen, Strikingly, there were no melanin pigments in H-E stain as well as in Masson-Fontana stain, which was thought to be a amelanotic melanoma. The patient was treated with B.C.G vaccination by intralesional and hypodermic injection, on the lesion and on both anterior thigh, respectively. One year after treatment, the lesion was markedly improved with only scar formation on previously ulcerated lesion. The patient shall be followed up continuously.

색소성 기저세포암과 공피양 기저세포암의 병발 1 례

이성낙,김중기 대한피부과학회 1978 大韓皮膚科學會誌 Vol.16 No.5

A black pigmented ulcerative, 1cm x 3cm nodule was developed in a 43 year old woman since 5 years ago. Clinically, it resembled the malignant melanoma and histopathological study revealed the combination of pigmented and morphea like basal cell epithelioma. Wide and deep excision down to oral mucosa with frozen section of free margin and primary closure had performed to bring the excellent cosmetic outlook. Both the pigmented basal cell epithelioma and morphea like basal cell epithelioma are reported rarely, however, to the best of our review of the English literature, this is the first of reported case of combinated type of pigmented and morphea like basal cell epitheliorna. We are now on close observation of the patient for recurrence and metastasis of the tumor.