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      • KCI등재후보

        진균혈증 ( Fungemia ) 에 대한 임상적 고찰

        김병일(Byung Il Kim),김준명(June Myeung Kim),김응(Eung Kim),홍천수(Chein Soo Hong) 대한내과학회 1989 대한내과학회지 Vol.36 No.5

        N/A Fungemia is usually a hospital acquired infection, which represents a severe and fatal disease. The incidence of fungemia is recently generally increasing due to the overuse or misuse of a broad spectrum of antibiotics, anticancer and immunosuppressive drugs, frequent application of open heart surgery and invasive procedures, such as various types of catheterization. We reviewed 30 fungemic patients admitted from January 1981 to June 1988 at Severance Hospital. The results were as follows: 1) Fungemia predominantly occurred in the first and fourth decades of life, with a mean age of 25.4 years, and the male to female retio was 1: 1.1. 2) Isolated species of the fungus were Candida albicans (27%), Candida tropicalis (3.3%), Candida glabrata (3.3%), Rhizopus species (3.3%) and Saccharomyces (3.3%) and yeast forms (60%) were also isolated. 3) Cardiovascular diseases (30%) were the major underlying diseases of fungemia, and sepsis due to medical illness (23.3%), hematologic malignancy (16.7%), and solid cancer (13.3%) were the following underlying diseases in order. 4) The underlying conditions associated with fungemia were long term antibiotic therapy (100%), concomitant baeterial infection (46.7%), central venous catheter insertion (43.3%). Foley catheter insertion (36.7% cardiovascular surgery (30.0%) and anticancer chemotherapy (26.7%). 5) The treatment of fungemia involved immediate removal of the underlying conditions followed by antifungal therapy with amphotericin B. 6) Of the 30 patients, 16 patients expired, resulting in a mortality rate of 53.3% In conclusion, when fungemia is suspected clinically or is proven by blood culture in patients who are immunocompromised or who have had cardiac surgery and in patients with prolonged antibiotic therapy, indwelling catheters and total parenteral nutrition, the correction of underlying conditions and early antifungal therapy should be indicated.

      • 1987년 가을 서울·경기지역에서 발생한 쯔쯔가무시병 18예에 대한 임상적 고찰

        김응,김영기,정동균,김준명,함영환,정윤섭,홍천수 대한감염학회 1988 감염 Vol.20 No.2

        Tsutsrgamushi disease is an acute febrile disease which is characterized by fever, headache, rashes and eschar. In Korea it has been reported with increasing frequencies through the nation since 1986. We have conducted a survey on 18 clinically suspected and serologically confirmed case of tsutsugamushi disease in Seoul and Kyungki Do from October 1987 to November 1987 and came up with following results. Of 18 cases, 11 were females and 7 were males. The mean age of the patients was 52 years ranging from 27 to 82 years. Twelve patients were found to be residing in the urban areas and 11 of these patients had a history of recent travel before the onset of the disease, suggesting acquisition of the disease from traveling in rural areas, and we were able to predict nation wide distribution of the disease. The most frequent symptoms were headache(100%), fever (100%) and chills (100%). Eschar was observed in 17 of 18 patients studied (94%). Common laboratory features include leukocytosis in 6 cases(33%), SGOT elevation in 17 cases(94%), SGPT elevation in 16 cases (89%), LDH elevation in 15 of 15 studied cases(100%) and the elevation in CK level in 1 of 6 studied cases (22%). On chest X-ray films, interstitial pneumonia was observed in 9 cases (50%) and pleural effusion in 3 cases. Serum fibrinogen was decreased in 6 of 15 studied cases (31%), FDP was positive in 4 of 15 studied cases (25%), antithrombin-Ⅲ was decreased in 5 of 7 patients (71%) and prolonged PT, PTT were observed in 2 of 18 patients (11%), each. Clinical improvement was noticed in all but one patient with either tetracycline or cholramphenicol treatment. The mean duration from the start of the treatment to the defervescence of fever was 1.8 days with tetracycline therapy and 2.1 days with cholramphenicol. During their clinical course, DIC was observed in 2 patient who did not have other superimposed infection. The mortality had occured in 1 patient complicated with pneumonia and ARDS.

      • KCI등재후보

        환자로부터 전파된 의료인의 말라리아 1 예

        홍천수,박왕견,김응,김준명,노형근 대한내과학회 1990 대한내과학회지 Vol.39 No.2

        Malaria infection is caused by the inoculation of a plasmodium species by a mosquito bite, but it can also be transmitted in other-than-natural circumstances. There are many reports of induced malaria cases, such as transfusion malaria incidentally related to clinical therapy, involving the transfer of either whole blood or its components, and accidental malaria due to the unintentional introduction of malaria parasites by a contaminated instrument or syringe in heroin users. But accidental transmission from human to human through a needle prick is very rare. We report here a case of direct malaria infection through a needle from patient to nurse, findings which can be very important to medical personnel.

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