Ki - 1 positive large - cell lymphoma ( Ki - 1 LCL )

김종혁(Chong Hyeok Kim),이성렬(Seong Yeol Lee),오칠환(Chil Hwan Oh) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.3

In 1985, Stein et al, indentified an anaplastic large-cell malignant lymphoma that was distinctive because of the diffuse dermal infiltration of pleomorphic large lymphocytes, sinus growth pattern, and reactivity with the monoclonal antibody Ki-1(CD30). The clinical feature; distinguishing anaplastic large-cell Ki-1 lymphoma include a young median age, frequent peripheral adenopathy with sparing of the mediastinum, and extranodal disease with skin the most common sitc of involvement. We report a case of Ki-1 postive large-cell lymphoma in a 74-year-old male patient who presented with multiple ulcerated nodules on the right shin area. (Kor J Derrnatol 1903; 31(3): 444-448)

염증 및 각화 이상 소견을 보이는 피부질환에서 Elafin 단백질의 발현 양상과 그 의의에 대한 연구

김종혁(Chong Hyeok Kim),송해준(Hae Jun Song),김수남(Soo Nam Kim) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.12

Background:Elafin is a serine proteinase inhibitor first discovered in keratinocytes from psoriatic epidermis. The molecular structure of elafin contains two different functional domains; one for the proteinase inhibitor, which is directed against elastase and proteinase-3, and the other for transglutaminase substrate. As this unique structural characteristic implies, elafin would be expected to have two distinct biologic functions in tissues. But, the roles and biological features of elafin have not been extensively studied in the skin. Objectives:This study was designed to demonstrate the immunohistochemical localization of elafin in inflammatory and keratinizing skin disorders, and to elucidate its biological functions. Materials and methods:The pre-elafin sequence was amplified by PCR using a human epidermal cDNA library and expression construct which was ligated into an expression vector. Then, the expressed proelafin sequence was purified and injected intradermally into rabbits to raise a polyclonal antibody. The skin biopsy samples of various skin diseases and normal controls were used for immunohistochemical staining to detect elafin expression. Results:1)Expression of elafin was observed in infected epidermis, and is believed to be involved in the defense mechanism of the skin. 2)In dermal and subcutaneous inflammatory diseases, epidermal elafin expression was influenced by the location of the inflammation. 3)Elafin was expressed in bullous dermatoses accompanied by acantholysis or spongiosis of epidermal cells. 4)Expression of elafin was upregulated in papulosquamous skin diseases which was characterized by epidermal hyperplasia and abnormal differentiation. 5)Elafin was expressed in keratinizing skin diseases that was accompanied by abnormal differentiation of epidermal cells. 6)Expression of elafin was demonstrated in skin tumors that showed proliferation of suprabasal cells. The intensity of (Korean J Dermatol 2000;38(12):1603~1614)

Clindamycin액에 의해 발생한 알레르기성 접촉 피부염

김종혁(Chong Hyeok Kim),문기찬(Kee Chan Moon) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.3

Contact allergy to clindamycin is rare, especially in relation to its widespread use in topical formulation. Neverthless, when patients using topical clindamycin complain of itching, patch testing with this preparation and its separate ingredients should be considered. We report a case of allergic contact dermatitis due to clindamycin solution for acne vulgaris therapy in a 24-year-old woman. (Kor J Dermatol 1992; 30(3): 368-372)

에크린 상피종

김종혁(Chong Hyeok Kim),김준영(Jun Young Kim),문기찬(Kee Chan Moon),김수남(Soo Nam Kim) 대한피부과학회 1992 대한피부과학회지 Vol.30 No.1

Eccrine epithelioma is an exceedingly rare cutaneous tumor ancit is believed to represent the maligant counterpart of the eccrine dermal syringoma. It occirs as an infiltrating basaloid growth, usually on the scalp or head, that frequently recur, apparrntly because of inadequate excision. We report a case of this tumor in a 60-year-old female, who showed a well demarcated, tender nodule on her left parietal scalp which had been present for three years. Histopat.hologically, the tumor was composed of strands of darkly staining epithelial cell embedded in a dense fihrcus stroma with ductal differentiation and cyst formation (Kor J Dermatol 1992; 30(1): 122-125)

Sodium Fusidate ( FucidinR 연고 ) 에 의하여 발생한 접촉 피부염 2예

김종혁(Chong Hyeok Kim),오용섭(Yong Sub Oh),홍승현(Seung Hyun Hong),계영철(Young Chul Kye),문기찬(Kee Chan Moon) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.6

Sodium fusidate, obtained by fermentation of the fungus, Fusidium coccineum, has a steroid structure and shows a very high antitaphycoccal activity. The allergic potentirl of sodium fusidate is low and few cases of contact allergy to sodium fusidate have been reported. We present two cases of allergic contact dermatitis to Fucidin cintentione developed postoperative dressing of a skin biopsy and the other after laser treatment of a vascular nevi. The patch test results showed positive reaction to sodium fusidate in both cases. (Kor J Dermatol 1993;31(6):944-947)

전신성 홍반성 낭창의 임상적 고찰

김종혁(Chong Hyeok Kim),이성렬(Sung Yul Lee),계영철(Kye Young Chul),문기찬(Kee Chan Moon),김수남(Soo Nam Kim) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.2

Background : Systemic lupus erythematosus(SLE) is a clinical syndrome of unknown causes characterized by inflammat.ion and multisystem involvement. Since Hargravas describe the LE cell in 1948, a profound change has occured in the concept of SLE. Many studies of the large series have been reported in the West, but few collective studies have been reported in Korea. Objective : The goal of this study was to elucidate the clinical and laboratory characteristics of SLE in Korean people. Methods : We carried out retrospective study of 64 patients, who were diagnosed as SLE on the base of the 1982 revised bacteria for the SLE by American Collepe of Rheumatology(formerly, American Rheumatism Association), at Korea University Hospital from 1982 to 1991. The results were compared with those of previous studies in Korea and western countries. Results : 1. In 64 patients with SLE, female patients outnumbered male by 6.1 to 1 and the mean age of onset was 28.6 years. 2. The initial manifestations were arthritis or arthralgia, 25%; fatigue, malaise, weight, loss, 21.8%; facial rash or blush, 12.5%, fever, 12.5%. 3. The major clinical manifastations were hematologic(90.6 %), muccutaneous(89%), musculoskeleta (79.7%), and renal(73.4%) involvemant. 4. The ANA test were positive in 83.9% of the patients, and homoenous pattern was most common. There was no significant difference of organ involvement according to the nuclear patterns of ANA, but cardiopulmonary, renal involvement, hypocomplement,emia and positive anti-ds DNA were less frequent in ANA neghative group. 5. In 73.7% of the patients, the titers of anti-ds DNA antibody was elevated. The amount of anti-ds DNA Ab in serum did not always correlate with disease activity. 6. Photosensitivity, arthritis or arthralgia and CNS manifestatioris were less common, but hematologic findings, including anenia and leukopenia were more common in Korean than western reports. Conclusion : Patients with SLE are heterogenous in the natural h story of their disease, which is not an uncommon disease in Korea. Continued efforts to clarify the immunopathologic basis for SLE should eventually lead to more effective treatment. (Kor J Dermatol 1994; 32(2): 258-270)

면역적격 환자에서 발생한 원발성 피부 모균증

조호연 ( Ho Youn Jo ),김종혁 ( Chong Hyeok Kim ),계영철 ( Young Chul Kye ),김수남 ( Soo Nam Kim ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.3

Mucormycosis is;n infectious disease caused by fungi of the order Mucorales. Almost all patients have a serious uriderlying condition such as diabetes mallitus, imrnunosuppression, starvation, burn, but a few cais have been reported in previously heilthy subjects. In order to successfully treat this infection, diagnosis must be prompt and acior. panied by aggressive debridement and parenteral administration of amphotericin B. We report a case of primary cutaneous mucormycosis in 58-year-old man. The lesion was a well-circumscribed erythematous plaque with central necrcis Histopathologically, a biopsy revealed broad, nonsptate with branches occuring at right anghles. (Kor J Dermatol 1995;33(3): 546-550)

한국인에서 안면 주름과 양성교근비대증에서의 A형 보툴리눔 독소 치료

노낙경 ( Nark Kyoung Rho ),김혜성 ( Hai Sung Kim ),김윤성 ( Yoon Seong Kim ),김연진 ( Yun Jin Kim ),김종혁 ( Chong Hyeok Kim ),민복기 ( Pok Kee Min ),서석배 ( Suk Bae Suh ),이강석 ( Kang Seok Lee ),이상주 ( Sang Ju Lee ),이우선 ( 대한피부과학회 2010 대한피부과학회지 Vol.48 No.10

Background: The utilization of botulinum toxin has rapidly expanded into various aesthetic applications. Achieving success with the aesthetic use of neurotoxins depends on several factors, including an understanding of the anatomy, the methods of dilution and the injection technique. Any guidelines representing a consensus for aesthetic treatments using botulinum toxin type A (BTA) have not been published in Korea. Objective: We wanted to provide consensus recommendations on the treatment of facial wrinkles and benign masseter hypertrophy using BTA in Korean patients. Methods: A panel of experienced Korean dermatologists was convened to develop a clinical consensus. The clinical consensus was comprised of the recommendations of the panel and the guidelines on general issues, such as the reconstitution and handling of the BTA, the procedural considerations, the dosing and injection-site standardizations, and the prevention and treatment of unwanted effects. Specific recommendations were provided according to the area of treatment, including glabellar lines, horizontal forehead lines, lateral periorbital wrinkles and benign masseter hypertrophy. Results: The recommended final concentration of BTA was 50 units/ml (5 units/0.1 ml) after reconstitution with physiologic saline. For glabellar lines, the members recommend three injection points (a total of 8 units). For forehead wrinkles, the members recommend nine injections in two rows into the frontalis with 1 unit/point. For crow`s feet, the members recommend three injections per side (7 units/side) at the lateral part of the orbicularis oculi. For benign masseter hypertrophy, three injections per side (24~30 units/side) were recommended. Conclusion: These consensus recommendations will provide a framework for Korean dermatologists who wish to perform safe and efficacious injection of BTA for facial rejuvenation. (Korean J Dermatol 2010;48(10):823~831)

민항기 door damper용 칼날형 댐핑 오리피스의 설계

홍예선(Yeh-Sun Hong),권용철(Yong-Cheol Kwon),김종혁(Chong-Hyeok Kim),박설혜(Seol-Hye Park),박호열(Ho-Yeol Park),김상범(Sang-Beom Kim) 한국항공우주학회 2012 韓國航空宇宙學會誌 Vol.40 No.12

본 논문에서는 작동유의 최대 동점성 계수가 400cSt까지 변하는 조건에서 항공기 도어댐퍼용 칼날형 댐핑 오리피스를 설계하였다. 전산 유동 해석과 실험을 통하여 칼날 오리피스의 유량계수를 분석하였고, 오리피스의 크기와 칼날 각도, 유동방향, 레이놀즈수가 미치는 영향을 고려하였다. 이 결과를 바탕으로 오리피스의 크기에 따라 댐퍼의 성능 기준을 충족시키기 위해 제한해야 하는 댐퍼의 쿨롱 마찰력 범위를 유도하였다. In this paper a sharp-edged type damping orifice for an aircraft door damper were designed, where the dynamic viscosity of working fluid were assumed to change up to 400cSt. The discharge coefficient of the damping orifice were investigated by CFD analyses and experiments. In particular, the influences of orifice diameter, edge angle, flow direction and the Reynolds number were taken into consideration. Based on this, it has been deduced how high Coulomb friction forces of damper seals is to be allowed to meet the performance criterion with respect to the orifice size.

악성 흑색종의 임상 및 병리조직학적 고찰

장경애(Kyoung Ae Jang),최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh),김종혁(Chong Hyeok Kim) 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.11

Background:Cutaneous malignant melanoma represents a tumor arising within the melanocytic systems of the skin. Once considered an uncommon cancer, melanoma is now rising in incidence at a rate faster than any other cancer. Objective:The purpose of this study was to investigate the clinico-pathological characteristics of malignant melanoma. Methods:A total of 61 patients with malignant melanoma were enrolled in this retrospective study. We classified malignant melanoma as follows; ALMM, acral lentigious malignant melanoma, NMM, nodular malignant melanoma, SSMM, superficial spreading malignant melanoma, MM, mucosal melanoma, LMM, lentigo maligna melanoma. We used the staging system of American Joint Committee on Cancer to evaluate the clinical status in our subjects. The hospital charts and histopathological slides of patients with malignant melanoma diagnosed at Asan Medical Center from 1989 to 1999 were reviewed. Immunohistochemical study was performed for S-100 and HMB-45 in 10 cases and for Ki-67 in 5 cases. Results:1. The male to female ratio was 1.3. The mean age at diagnosis was 52.6 years. ALMM was the most common type(52.5%) in this study. ALMM and NMM developed in elderly persons, while SSMM developed in younger persons. Malignant melanomas arising from pre-existing mole were 10 cases(16.4%). 2. In forty two cases(68.9%), malignant lesions were limited to skin, but 19 cases(31.1%) were disseminated to lymph nodes, skin or internal organ at the initial examination. Sole and heel were the favored sites in ALMM. Lower extremities and back were the favored sites in NMM and SSMM. Four patients were initially presented with metastatic symptoms such as dyspnea, abdominal mass, headache, or axillary mass, and cutaneous malignant melanoma eventually were diagnosed as their origin.3. Histopathologically, 6 cases were categorized into amelanotic type and 1 case was into desmoplastic type.4. More than a half cases developed metastases to other organs. Common metastatic sites were lymph nodes, lung, brain, skin, liver, bone, and bladder in decreasing order of frequency. 5. The five-year survival rate was 100% in stage IA, IB, and IIA but 0% in stage IV. Face, chest and lower extremities showed worse prognosis. Men had worse prognosis than women. NMM revealed the lowest 5-year survival rate(30%). Conclusion:Among the prognostic factors such as locations, clinical types, ages, and gender, the stages at the initial presentation was the most important predictable value in our study. Therefore, the early recognition of malignant melanoma is the key to possible cure.(Korean J Dermatol 2000;38(11):1435~1443)