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구강 편평세포암종에서 p53 단백과 Cyclin D1발현에 대한 면역조직화학적 연구
김종엽,김경욱,이재훈,김창진,Kim, Jong-Yub,Kim, Kyung-Wook,Lee, Jae-Hoon,Kim, Chang-Jin 대한악안면성형재건외과학회 1999 Maxillofacial Plastic Reconstructive Surgery Vol.21 No.2
Oral cancer is a common neoplasm in humans and etiologic mechanism is not well known, so treatment and evaluation of oral cancer is difficult problem. Traditional TNM classification between prognosis of tumors and classification of histopathologic differentiation has problem like lack of objectivity through operators. In molecular biology, cancer is developed by alteration of activation of oncogene and/or inactivation of tumor suppressor gene. The p53 gene, one of the tumor suppresor genes, is believed to play an important role through mutation and overexpression in the progression of human cancers. The p53 mutation is most frequent genetic disorder in humans. The Cyclin D1 has tumor suppresion activity by regulation of cell cycle. The Cyclin D1 regulate activity of Rb tumor suppresor gene by stimulation of CDK4 The purpose of this study was to observe the expression of p53 protein and Cyclin D1 in oral squamous cell carcinoma, and to get expectation of the malignancy and prognosis of oral squamous cell carcinoma. Using the 15 cases of squamous cell carcinoma and the microscopic H&E and immunohistochemical stain. We divided it into 3 groups according to the stain extent, clinical stage and histologic differentiation. The results were as follows1.In the features of immunohistochemical stain of 15 cases of squamous cell carcinoma, positive reaction of p53 was identified in 8 cases (53.3%) and positive reaction of cyclin D1 was identified in 3 cases (20%). Both positive reaction of p53 protein and Cyclin D1 was show in only one case. 2.8 of p53 positive cases were linked in 87.5% of the end stage tumor, 62.5% of neck node involvement, 87.5% of poorly and moderately histopathplogic differentiation. 3. All 3 of Cyclin D1 positive cases were linked in the end stage tumor, neck node involvement, poorly and moderately histopathologic differentiation. From above results, expression of p53 protein was identified in 53.3% of 15 cases and these results mean oral squamous cell carcinoma was drived by mutation of p53 protein. Especially, highly positive reaction of p53 protein and Cyclin D1 was identified in cases that involvement of neck lymph node and the end stage tumors and it means that the evaluation of p53 protein and Cyclin D1 was useful for evaluation of malignant tumor as specific tumor marker.
Multirate를 위한 이동국 Rake Finger의 성능 개선에 관한 연구
김종엽,이선근,박형근,김환용,Kim, Jong-Youb,Lee, Seon-Keun,Park, Hyoung-Keun,Park, Hwan-Young 대한전자공학회 2001 電子工學會論文誌-SD (Semiconductor and devices) Vol.38 No.12
In this paper, we proposed the new structure of the Rake Finger using Walsh Switch, the shared accumulator, and the pipeline FWHT(Fast Walsh Hadamard Transform) algorithm for reducing the signal processing complexity resulting from the increase of the number of data correlators. The function simulation of the proposed architecture is performed by Synopsys tool and the timing simulation is performed by Compass tool. The number of computational operation in the proposed data correlators is 160 additions and the conventional ones is 512 additions when the number of walsh code channels is 4. As a result, it is reduced about 3.2 times other than the number of computational operation of the conventional ones. Also, the result shows that the data processing time of the proposed Rake Finger architecture is 90,496[ns] and the conventional ones is 110,696[ns]. It is 18.3% faster than the data processing time of the conventional Rake Finger architecture. IMT-2000의 무선접속 기술 요소 중 multirate을 위한 Multi-Code(MC) CDMA 시스템의 이동국 Rake 수신기는 다수의 채널로 전송된 신호들을 동시에 복조해야 하므로 Rake Finger에서 트래픽 채널을 복조하는 데이터 상관기의 수가 왈쉬 코드 채널의 수만큼 증가하게 되어 신호처리의 복잡도가 증가되는 단점을 갖게 된다. 본 논문에서는 데이터 상관기들의 증가로 인한 데이터 처리시간 지연을 감소시키기 위해 Walsh Switch, 공유 accumulator, 그리고 파이프라인 FWHT(Fast Walsh Hadamard Transform) 알고리즘을 적용한 새로운 Rake Finger 구조를 제안했다. 컴퓨터 시뮬레이션 결과 왈쉬 코드 채널의 수 에 대한 데이터 상관기의 연산 동작 수는 512 additions에서 160 additions로 약 3.2배 감소하였고, Rake Finger의 데이터 처리시간은 110,696[ns]에서 90,496[ns]로 18.3% 감소하였음을 확인하였다.