석면 비산 장비를 이용한 토양 중 석면 비산 특성 및 위해성 평가

김인자,김정욱,류현식,정명채,Kim, In Ja,Kim, Jeong-Wook,Ryu, Hyun Sik,Jung, Myung Chae 한국지하수토양환경학회 2012 지하수토양환경 Vol.17 No.5

The objective of this study is to examine a releasable asbestos sampler developed for measuring friable asbestos from soil to air controlled by wind velocity and water contents. Asbestos contaminated soil with 3.75% at the Sinsuk-asbestos mine was sampled, air-dried and sieved to 100 mesh, then homogenized during 24 hours' agitation. Various wind velocities, 1 m/s, 2 m/s, 3 m/s, and 5 m/s, were applied to evaluate releasable characteristics of the releasable asbestos sampler. In addition, soils with 1.0%, 3.4%, 4.4%, 11.0%, 16.2%, and 20.0% of water contents were also examined the amount of friable asbestos by the releasable asbestos sampler. Collected soil and air samples were analyzed by polarized light microscopy (PLM) and phase contrast microscopy (PCM), respectively. Those contents were applied to calculate an excess life cancer risk (ELCR). This study also discussed the relationship with risk assessment by a weeding scenario of activity based sampling (ABS) and field applied releasable asbestos sampler. The result was shown that friability of asbestos in soil increased with wind velocity and decreased with water content. In comparison with ELCR results, over 10E-4 of cancer risk was found in condition on < 5% water content and > 3m/s wind velocity.

노인의 인지기능과 구강건강상태의 관련성: 고령화연구패널조사(Korean Longitudinal Study of Aging)를 중심으로

김인자,문희정,Kim, In-Ja,Moon, Hee-Jung 한국치위생학회 2022 한국치위생학회지 Vol.22 No.5

Objectives: This study aimed to confirm the association between cognitive function and oral health status in the elderly. Methods: In this study, 5,794 respondents, aged 55 or older, who had participated in the 7th aging research panel survey were used. Statistical analyses were performed using a complex samples cross-tabulation analysis, complex samples general linear model, and a complex sample multinomial logistic regression analysis. Results: After analyzing the cognitive function of the elderly according to their oral health conditions, it was found that suspicions of dementia (19.6%) and cognitive function decline (25.9%) were more common for those who wore dentures than for those who did not wear dentures (p<0.001). Compared to those who did not wear dentures, those who wore dentures were linked to a 1.665 times higher suspicion of dementia (p<0.001). In comparison, cognitive decline was 0.964 times lower when the number of natural teeth increased by 1, and it was 0.941 times lower when the oral health evaluation index for the elderly increased by 1 point (p<0.001). Conclusions: As a result of this study, it was confirmed that cognitive function and oral health status are related in the elderly. Therefore, systematic measures for oral health management and oral health promotion should be prepared in tandem with awareness of possible cognitive decline in the elderly.

신종인플루엔자 감염학생의 스트레스와 자가치료지침 수행

박진희(Park, Jin Hee),강정희(Kang, Jeong Hee),김인자(Kim, In Ja) 한국간호교육학회 2011 한국간호교육학회지 Vol.17 No.2

Purpose: This study examined levels of stress and adherence to self care guidelines in elementary and middle school students who were infected with the influenza A (H1N1) virus in 2009. Method: A total of 649 students from J city participated in the survey. Stress was measured with the Impact of Event Scale-Revised which was developed by Weiss and Marmar (1997) and translated by Eun and colleagues (2005). Adherence to self care guidelines was measured with the scale developed by the authors based on the self care recommendations from Korea Centers for Disease Control and Prevention. Result: Levels of stress and adherence to self care guidelines were higher in elementary school students. However, the severity of participants stress was less than moderate. The adherence level was significantly different depending on status of taking an antiviral agent, health education and self care education regarding the virus infection. Conclusion: Findings suggest that effects of health education under the national crisis situation due to influenza A (H1N1) virus pandemic were helpful. More in-depth study is needed to understand and to improve middle school students self care behaviors.

효과적인 의사소통 기술

김인자,Kim In-Ja 한국공학기술학회 1999 공학교육과 기술 Vol.6 No.3

한국 청소년에서 치아우식증 고위험군의 우식양상

김인자 ( In Ja Kim ),주현정 ( Hyun Jeong Ju ),이선호 ( Sun Ho Lee ),나자영 ( Ja Young Na ),오효원 ( Hyo Won Oh ),이흥수 ( Heung Soo Lee ) 대한구강보건학회 2016 大韓口腔保健學會誌 Vol.40 No.2

Objectives: The purpose of this study was to analyze the pattern of dental caries in a high-risk group of Korean adolescents. Methods: Raw data on 10,542 adolescents between the ages of 12 and 15 years from the 2012 Korean National Oral Health Survey was used. The subjects were divided into a high caries risk group and non-high caries risk group for analysis. For the statistical analyses, we utilized a frequency analysis, descriptive statistics, and a multidimensional scaling analysis. Results: The pattern of dental caries in the high caries risk group were divided into six classifications for 12-year-olds and five for 15-year-olds, including the mandibular first molar occlusal surface (Cluster 1). In the high caries risk group, the frequency of Cluster 1 was approximately 4-times higher in 12-yearolds than that in the non-high caries risk group of Cluster 1, and about 3-times higher in 15-year-olds. The multidimensional scaling analysis found that in the high caries risk group, the same types of tooth surfaces formed separate groups. The prevalent dental caries pattern of 12-year-olds in the high caries risk group was left-right symmetry, while in the 15-year-olds of the high caries risk group, the caries pattern also included the antagonistic teeth, along with left-right symmetry. However, the non-high caries risk group had a pattern of left-right symmetry only in the 15-year-olds. Conclusions: When dental caries occur in the first molar, there is a high possibility of being classified into the high caries risk group. Therefore, preventative measures should focus on the antagonistic teeth and the teeth on the opposite side.

연화향(蓮花香) 정유액이 glioma cell에 미치는 효과

김인자 ( In Ja Kim ),이주연 ( Joo Yeon Lee ),최방섭 ( Bang Seob Choi ),김근우 ( Geun Woo Kim ),구병수 ( Byung Soo Koo ) 대한한방신경정신과학회 2008 동의신경정신과학회지 Vol.19 No.2

Objective : Herb medicines are potential sources of useful edible and medicinal plants. They are used as a drug because of their various biological activities such as immunomodulatory, antiviral, and antitumor functions. Nelumbo nucifera have been applied in Chinese herbal prescriptions to improve tissue inflammation. However, it has not been elucidated on the effect of the flower of Nelumbo nucifera in cells. Method : In the present study, to examine the effect of that on glioma cells, U87, the essential oil was extracted from the flower of Nelumbo nucifera (NN essential oil). U87 cells were exposed to different concentrations of 2-40 ug/ml of NN essential oil in ethanol. Cell viability was measured by MTT assay at 24 h. To find out the intracellular target signal molecule(s) for this antiproliferative activity of NN essential oil, phosphorylation of Akt, ERM, MAPK or p38 proteins were examined by Western blot analysis. To study long term effect of NN essential oil in U87 cells, the image of cells treated with NN essential oil for 4 days were obtained. Results and Conclusion :. NN essential oil was shown to exhibit antitumor activity in glioma cells, at a broad range of concentrations of 10-40 ug/ml. The phosphorylation of Akt and Endoplasmic Reticulum Matrix (ERM) proteins which known to be involved in the cell death, were gradually decreased to 2 hours after addition 20 ug/ml of NN essential oil. However, the phosphorylation of mitogen-activated protein (MAPK) and p38 was found to increase in NN essential oil treated cells. NN essential oil treated cells showed decreased glioma cell number. These results provide a possible NN essential oil-induced inhibitory signal for tumor cell proliferation that is initiated by the decrease in Akt activity. Moreover, it is likely that the activation of p38 is required for the NN essential oil-induced inhibition of tumor proliferation.

MPTP로 유도된 Parkinson`s disease 동물 모델을 이용한 소합향원(蘇合香元)의 신경보호 효과 및 그 작용 기전 연구

김인자 ( In Ja Kim ),이지현 ( Ji Hyun Lee ),송규주 ( Kyoo Ju Song ),구병수 ( Byung Soo Koo ),김근우 ( Geun Woo Kim ) 대한한방신경정신과학회 2012 동의신경정신과학회지 Vol.23 No.1

Objectives : To evaluate the neuroprotective effects of the essential oil from Sohaphwangwon (SH), a Chinese traditional medicinal prescription in a Parkinson`s disease mouse model. Methods : 1. The neuroprotective effect of SH on primary neuronal cells was examined by using 1-methyl-4-phenylpyridinium ion (MPP+). 2. The neuroprotective effect of SH was examined in a Parkinson`s disease mouse model. C57BL/6 mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30 mg/kg/day), intraperitoneal (i.p.) for 5 days. SH inhalation was applied before MPTP treatment for 7 days and continued until 12 days after the first MPTP treatment. 3. To find out the intracellular target signal molecule(s) regarding the neuroprotective effect of SH essential oil, brain-derived neurotropic factor (BDNF) and synaptic protein SNAP25 were examined by Western blot analysis. Results : 1. MPP+ induced a concentration-dependent decrease in cell viability. However, in the presence of 3 and 5 ug/ml of SH, MPP+-induced cell death was significantly reduced. 2. SH inhalation in MPTP mice led to the restoration of behavioral impairment and rescued tyrosine hydroxylase (TH)-positive dopaminergic neurodegeneration. 3. In SH / MPTP mice, BDNF and SNAP25 increased. Conclusions : This experiment suggests that the neuroprotective effect of SH essential oil is mediated by the expression of BDNF. Furthermore, SH essential oil may serve as a potential preventive or therapeutic agent regarding Parkinson`s disease.

우리나라 12세 아동 영구치아 간의 우식발생 연관성

김인자 ( In-ja Kim ),이동연 ( Dong-yeon Lee ),이흥수 ( Heung-soo Lee ),오효원 ( Hyo-won Oh ) 대한예방치과·구강보건학회 2023 大韓口腔保健學會誌 Vol.47 No.2

Objectives: The objective of this study was to analyze dental caries incidence in the permanent teeth of 12-year-old children. Methods: This study used the raw data from the 2015 Korean children’s oral health survey. Participants of the research were 12-year-old children in their first year of middle school. A total of 27,291 people participated in the questionnaire and oral examination. Statistical analysis was performed using complex samples frequency analysis and contingency coefficient phi (φ). Results: Dental caries predominately developed symmetrically with a higher tendency for left-right symmetry than for maxillary-mandibular symmetry in the mouth. The incidence of dental caries between adjacent teeth had a statistically significant correlation and was highest in the first and second premolars. Conclusions: Information on symmetry in the development of dental caries and the association of dental caries incidence between adjacent teeth of 12-year-old children should be actively utilized when establishing evidence-based dental caries management plans.

과학기술 규제 정책의 형성과 변동 과정분석 -「생명윤리 및 안전에 관한 법률」을 중심으로-

김인자 ( In Ja Kim ),박형준 ( Hyung Jun Park ) 한국정책학회 2011 韓國政策學會報 Vol.20 No.1

본 연구는 생명윤리법을 중심으로 정책변동에 영향을 주는 요인인 정책 환경과 정책하위체제 내 정책참여자들의 관계를 포함하여 과학기술 규제정책의 형성과 변동 과정을 분석하고자 한다. 생명윤리법은 육성의 대상인 생명공학기술에 대해 허용된 범위와 정부의 승인 하에 연구를 수행하도록 하는 규제를 만듦으로써 패러다임 변화적 정책변동을 가져왔다고 할 수 있다. 이를 위해 신념체계에 의한 정책옹호연합의 형성 및 장기간 정책변동을 설명하는 ACF모형과 정책변동의 역동성을 설명하는데 유용한 다중흐름모형을 보완하여 분석틀을 설정하였다. 분석 결과, 정책하위체제에 영향을 주는 정책 환경은 민족주의, 경제성장지상주의, 국가경쟁력의 원천, 생명공학육성법이며, 정책참여자는 배아복제를 금지하는 규제옹호집단과 찬성하는 육성옹호집단을 들 수 있다. 정부 밖의 규제옹호연합과 육성옹호연합은 생명윤리와 국익이라는 신념체계에 의해 갈등을 나타낸 반면, 정부는 생명윤리법 제정과정에서 임무에 따른 정책지향의 차이와 새로운 관할권 설정을 위한 주도권 경쟁에 의해 대립하였다. 과학기술 규제정책의 창은 문제의 창에서 주로 열렸다. 실현가능성 있는 정책대안 도출과 정책흐름을 결합하고 정책을 산출하는데 정책중개자와 정책창도자가 중요한 역할을 하고 있음이 확인되었다. 또한 정책결정이 시간의 제약 하에 비합리적으로 이루어지고 있음도 확인되었다. This study intends to analyze the policy formation and change process of science and technology regulation related with Bioethics Issues. What is less clear is how bioethical considerations have formed and changed in science & technology policy design. Therefore we examined the dynamic process of enactment and amendment of ``Bioethics & Biosafety Law`` in Korea for finding answer to theses questions. What factors to open policy window, what factors influence the policy formation and changing policy in science & technology policy related with bioethics. There are controversial debates between two parties, human bioethics versus economic profits. It can be said that bioethical consideration has brought a policy change and creating a new regulation system from positive to negative. To this end, an analytic framework was set up by complementing the model of advocacy coalition framework, which explains the formation of policy advocacy coalition by belief system and long-term policy changes, and the model of multiple stream framework, which is useful to explain the dynamics of policy change. The results of analysis showed that the policy environment affecting policy subsystems are nationalism, economism, national competitiveness, and biotechnology promotion law, and participants of policy-making include the regulation advocacy group against embryonic cloning and the promotion advocacy group for it. While the conflict between these coalition groups outside the government was based on their belief systems of bioethics and national interest, the conflict within the government originated from the differences in policy orientation among offices in the process of enacting the Bioethics and Biosafety Law and a struggle for leadership in establishing a new jurisdiction. The policy window for science and technology regulation mostly opened in the problem window. It turned out that policy brokers and policy entrepreneurs play an important role in deriving feasible policy alternatives, combining policy streams, and shaping policies. It also turned out that irrational policy decisions are made under time constrictions.

근로자의 근무형태에 따른 치과치료필요도 비교

주온주 ( On-ju Ju ),김인자 ( In-ja Kim ) 한국치위생학회(구 한국치위생교육학회) 2019 한국치위생학회지 Vol.19 No.3

Objectives: The purpose of this study was to compare the dental treatment needs of workers depending on their shifts and working patterns. Methods: Only workers aged 15 or older according to the 6th Korea National Health and Nutrition Examination Survey (2013-2015) were considered eligible. A total of 9,092 people who responded to health surveys and completed oral examinations and interviews were selected for the study. Statistical analysis was carried out by the complex samples general linear model. Results: As the daytime workers’ age increased, the requirement for restorative treatment decreased. In contrast, the requirement for tooth extraction caused by dental caries and periodontal disease increased. As the evening shift workers’ age increased, the requirement for restorative treatment decreased. In the case of shift workers, the requirement for restorative treatment was lowest in those aged 50-64 years and highest in those aged 30-49 years. In the case of smokers; the daytime workers required a higher amount of restorative treatment, pulpal treatment, and tooth extraction due to dental caries and periodontal disease; the night shift workers required a higher amount of restorative treatment; and the shift workers required a higher amount of tooth extraction caused by periodontal disease. The results of comparing the dental treatment needs depending on working patterns were: the need for restorative treatment was higher in night shift workers (0.377) than in shift workers (0.245); the requirement for pulpal and restorative treatment was higher in daytime workers (0.055) than in night shift workers (0.010); requirement for tooth extraction due to periodontal disease was higher in night shift workers (0.060) than in evening shift workers (0.012). Conclusions: There are differences in dental treatment needs depending on the workers’ working patterns. Collective oral health care is needed at workplaces to promote the workers’ oral health.