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김이중,신실 대한피부과학회 1978 大韓皮膚科學會誌 Vol.16 No.1
Many modalities for the treatment of acne vulgaris have been introduced, but the results of the treatment were variable and unsatisfactory. In 1969, Kligman ct al reported that vitamin A acid was one of the mot effective raembers of the topical therapeutics for ance than any other topical remedies. But the undesirable side effects of vitamin A acid limit its use, and so we us instead of vitamin A acid for minimizing of possible side effects The results are as follows: 1. The total number of skin eruption progressively diminished after treatment with topical vitamin A acid derivatives and we found significant diminution on fourth week, and the effectiveness of the total patients was 73.7%. 2. The number of papules and closed comedories progressively diminished after treatment, but that of open corzelones slightly increased on first week of the treatment and diminished thereafter. 3. The number of pustules too few to evaluate with statistical analysis, but newly developed pustules noted speciaelly in first and second weeks wit.h unpredictable courses 4. The frequent, undesirable side effects were scale, buming & stinging and erythemas in order of frequeny, but other side effeccs auch as itching, tightness, pain, and pigmentation also noted in a few patients but the side effects were mild. So we considered the effectiveness of vitamin A acid derivatives were as good as those of vitamin A acid, but the undesirable side effects of vitamin A acid. derivatives were less severe than those of vitamin A acid.
위 윤상근 세포의 Ca^(2+) - 작동성 K+ - 전류에 관한 연구
김이중,방효원,엄대용,이상돈 중앙대학교 의과대학 의과학연구소 1990 中央醫大誌 Vol.15 No.4
In order to study the presence and properties of K^++ currents, especially Ca^(2+)-dependent one which was known in other smooth muscle cells but scarcely in mammalian gastric circular muscle cells, the patch clamp experiments with whole cell mode were conducted using single smooth muscle cells after digestion of circular muscle strips of rabbit's pyloric antrum with collagenase. The followings were obtained: 1. Large outward oscillatory' currents were recorded when the internal solution was K-Aspartate. 2. These currents showed dependence on the intra-and extracellular calcium ion, extracellular verapamil and pH. 3. These currents could be blocked completely by intracellular cesium ion and TEA. 4. Recovery process of the current with time was very slow and the inactivation with conditioned potentials was incomplete. Therefore, this current would be the Ca^(2+)-dependent K^+ current in a circular smooth muscle cell of gastric pylorus which should be important in repolarization and excitability in general.