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골텍스(Gore-Tex) 삽입물을 이용한 코높임술의 임상경험
김응삼 대한성형외과학회 2004 Archives of Plastic Surgery Vol.31 No.1
The dorsal augmentation is the most common rhinoplastic procedure performed by cosmetic surgeons. To date, however, there are few published cases of rhinoplasty with Gore-Tex in Korea. The present work reports the results of retrospective analysis on photographic reviews and interviews obtained from patients, who have undergone rhinoplastic surgery with Gore-Tex for the past two years in my clinic. A total of 146 patients (23 males and 123 females) with age of 15 to 62 years were monitored for 2 to 24 months after surgery from May 2001 to April 2003. Clinical data was compiled through the in- depth comparison of preoperative and postoperative chart assessment. Both the degree of satisfaction and complaints about foreign body sensations were evaluated based on interviews with patients and measured quantitatively by Leichert scale.The results show that a 75 out of 164 patients were satisfied with surgery outcomes and average points were 3.24(scoring 1 to 5 according to the satisfaction rate). About foreign body sensation, 15 out of 137 patients complained of significant foreign body sensation and average points were 2.12(scoring 1 to 5 according to severity of foreign body sensation). Clinically, the Gore- Tex implant in the cases reported in this study were found to have stability and tissue tolerance.
김응삼,한기호,조영호,김문언,Kim, Eung-Sam,Han, Ki-Ho,Cho, Young-Ho,Kim, Moon-Uhn 대한전기학회 2001 전기학회논문지C Vol.49 No.5
In this paper, we present theoretical and experimental study on the viscous damping of the on-substrate torsional micromirrors, oscillating near the silicon substrates. In this theoretical study, we develop theoretical models and test structures for the viscous damping of the on-substrate torsional micromirrors. From a finite element analysis, we estimate the theoretical damping coefficients of the torsional micromirrors. From a finite element analysis, we estimate the theoretical damping coefficients of the torsional micromirrors, fabricated by the surface-micromaching process. From the electrostatic test of the fabricated devices, frequency-dependent rotationalvelocity of the micromirrors has been measured at the atmospheric pressure using devices, frequency-dependent rotational velocity of the micromirrors has been measured at the atmospheric pressure using the Mach-Zehnder interferometer system. Experimental damping coefficients have been extracted from the least square fit of the measured rotational velocity within the filter bandwidth of 150 kHz. We have compared the theoretical values and the experimental results on the dynamic performance of the micromirrors. The theoretical analysis overstimates the resonant frequency in the amount of 15%, while underestimating the viscous damping in the factors of 10%.
김응삼,김창옥,박준원,최관용 한국바이오칩학회 2011 BioChip Journal Vol.5 No.2
High capability to distinguish single-nucleotide mismatches of genes using short oligonucleotide probes is essential in diagnostic methods for identification of point mutations and single nucleotide polymorphisms. To investigate the feasibility of using an aziridine-treated surface containing hyper-branched amine groups to discriminate single-nucleotide mismatches in a human gene, target probes for exons 5-8 of the p53 gene from liver cancer cells were hybridized with four types of surface-bound capture probes, one for perfect match and three for central single-nucleotide mismatches. The aziridine slide with high DNA-loading capacity exhibited greater ability to detect single-nucleotide mismatch than did the generic amine slide. When a T30 tether was linked to the capture probe, the mismatch discrimination capability increased when using a chemical cross-linker, but decreased when using UV irradiation for cross-linking. DNA duplexes had lower melting temperatures when the single-nucleotide mismatch was in the central region than when it was in the terminal region regardless of the type of mismatched nucleotide. Our results suggest that capture probes attached to the aziridine surface can effectively identify point mutations in a genomic sequence or and can estimate the affinity of gene-specific antisense oligonucleotide probes.
김응삼,김덕호,안은현,정의헌 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.6
Nanotechnology-based tools are beginning to emerge as promising platforms for quantitative high-throughput analysis of live cells and tissues. Despite unprecedented progress made over the last decade, a challenge still lies in integrating emerging nanotechnology-based tools into macroscopic biomedical apparatuses for practical purposes in biomedical sciences. In this review, we discuss the recent advances and limitations in the analysis and control of mechanical, biochemical, fluidic, and optical interactions in the interface areas of nanotechnology-based materials and living cells in both in vitro and in vivo settings.
Micro-/Nanotechnology-Based Isolation and Clinical Significance of Circulating Tumor Cells
김응삼,한기호,최관용,Seonyoung Kim 대한의용생체공학회 2012 Biomedical Engineering Letters (BMEL) Vol.2 No.2
Circulating tumor cells (CTCs) are extremely rare in peripheral blood, and they are mostly derived from primary and metastatic epithelial tumors. Recent studies have reported that the presence of CTCs is an independent predictor of progression-free survival and overall survival of metastatic cancer patients, and is proportional to the progression of the disease when a carcinoma recurs. Because of the extremely low concentration of CTCs in peripheral blood (1-2 per 10 billion blood cells), the isolation and characterization of CTCs are major technological challenges. Recent micro-/nano-based technical advances are providing new opportunities for the isolation of purer CTCs from peripheral blood and better cellular and molecular characterization. This review focuses on available micro-/nano-based techniques for the detection of CTCs, clinical utilities of CTCs and their limitations, and future perspectives in this field.
나동균,탁관철,이훈범,김응삼 大韓成形外科學會 1997 Archives of Plastic Surgery Vol.24 No.1
Microsurgical techniques have developed numerous territories suitable for free tissue transfer. However, there are so many flaps in plastic and reconstructive surgical field, so no one dare to say which flap is the best. The radiovolar area of the forearm constitutes a versatile source for composite tissue free flap reconstruction for many areas of the body. The skin is thin and relatively hairless, and the vascular pedicle is long and large caliber. The flap can be harvested conjunction with tendons and bone. The skin can be reliably reinnervated. We have used 32 radial forearm free flaps to reconstruct defect in various areas of the body resulting from tumor ablation, post bum scar contracture and penile amputation injury. We had two flap failures, one developed necrosis from venous thrombus formation, the other from the infection due to sepsis. Thirty of 32 flaps survived completely. Overall survival rate was 94%. the donor sites have been relatively inconspicuous.
편도암 절제후 요골측 전박 유리피판을 이용한 재건 및 술후 구음 기능의 평가
김응삼,신극선,이훈범,정섬 大韓成形外科學會 1997 Archives of Plastic Surgery Vol.24 No.3
Four consecutive patients underwent composite resection of tonsillar cancer and reconstruction with a microvascular radial forearm free flap. Three patients had postoperative assessments of speech at six to nine months respectively. One patient could not attend for the postoperative assessment. The speech assessment was examined by same speech therapist. All the patients had an good postoperative speech assessment. Compared to conventional local or regional myocutaneous flaps, the thin forearm free flaps offers better postoperative articulatory recovery.