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RISS 인기검색어
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- 저자 : 김순중 ( Soon Joon Kim ) (검색결과 3 건)
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방풍통성산이 흰쥐의 Adjuvant 유발 관절염에 미치는 영향
엄관준 ( Kwan Joon Eom ),김지영 ( Ji Young Kim ),김순중 ( Soon Joong Kim ),서일복 ( Il Bok Seo ),정수현 ( Su Hyeon Jeong ) 한방재활의학과학회 2012 한방재활의학과학회지 Vol.22 No.2
Objectives :This study was carried out to investigate the effects of Bangpungtongseong-san(Fangfengtongsheng-san) treatment on the change of the adjuvant-induced arthritis in rats. Methods :Arthritis was induced by injection of complete Freund`s adjuvant(CFA, 0.1 ml) into the tail base of rats. Arthritic rats were divided into control(n=8) and treated(n=8) group. The control group was taken distilled water and the treated group, extracts of Bangpungtongseong-san(Fangfengtongsheng-san) by orally for 15 days. At the end of the experiment(28 days after CFA injection), gross and histopathological examinations on the articular structures of ankle joints were performed. The total number of white blood cells was measured by the ADVIA(automated blood cell counter, Bayer Co., Ireland). And also, tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) contents in paw exudate of rats were measured by enzyme-linked immunosorbent assay(ELISA) method. Results :1. Body weight(g) gain rate(%) of the treated group was increased significantly compared with control group at the 15th day after injection. 2. The thickness of ankle joints of the treated group was decreased significantly compared with the control group. 3. Histopathologically, finding of fibrous ankylosis of the treated group was decreased compared with the control group. 4. The total number of white blood cells in the treated group was decreased significantly compared with the control group. 5. TNF-α content and IL-1β content in paw exudate of the treated group were decreased significantly compared with the control group. Conclusions :On the basis of these results, we suggest that Bangpungtongseong-san(Fangfengtongsheng-san) has inhibiting effects on the progression of arthritis in CFA-induced arthritis model.
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하지길이 차이에 따른 척추기립근의 분석 -경근전도를 통해
윤대연 ( Dae Yeon Yoon ),최진서 ( Jin Seo Choi ),정수현 ( Su Hyun Jeong ),김순중 ( Soon Joon Kim ) 한방재활의학과학회 2011 한방재활의학과학회지 Vol.21 No.3
Objectives: We studied the clinical utility of meridian electromyography for the assessment of erector spinae muscle in functional leg length inequality. Methods: We compared electrical activity between A group with a functional leg length inequality(n=17) and B group(n=23) in dynamic flexion-reextension state during five minutes. We analyzed amplitudes and areas of electrical activity and asymmetry index(AI). Results: 1. The short leg sides were significantly higher electrical activity than the long leg sides in the experimental group and control group(p<0.05). 2. The AI of A group significantly higher than B group(p<0.05). Conclusions: According to above results, there are correlations between erector spinae muscle and functional leg length inequality.
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삼기음(三氣飮)이 흰쥐의 Monosodium Iodoacetate 유발 골관절염에 미치는 영향
이경무 ( Kyung Moo Lee ),정수현 ( Su Hyeon Jeong ),김순중 ( Soon Joon Kim ),서일복 ( Il Bok Seo ) 한방재활의학과학회 2008 한방재활의학과학회지 Vol.18 No.2
Objectives : This study was carried out to investigate the effects of Samgi-eum(Sanqi-yin) on the monosodium iodoacetate-induced osteoarthritis in rats. Methods : Osteoarthritis was induced by injection of monosodium iodoacetate intraarticularly in both knee joints. Arthritic rats were divided into control and treated group. Control group were taken distilled water for 20days. Treated group were taken extracts of Samgi-eum(Sanqi-yin) by orally for the same duration. Normal group were injected normal saline and taken distilled water. Body weights were measured at 0, 5th, 10th, 15th, 20th day after injection. At the end of the experiment, gross and histopathological examination on the articular cartilages of the knee joints were performed. Proteoglycan contents of articular cartilages were analyzed by safranine O staining method. The contents of TNF-α, IL-1β and IL-6 in synovial fluids were analyzed by ELISA method. Results : 1. Body weights of the treated group were significantly increased compared with control at 20days after injection. 2. Grossly, the severity of osteoarthritis in the treated group were alleviated compared with control. 3. Histopathologically, degenerative and necrotic lesion of articular cartilages in the treated group were alleviated compared with those of the control and histopathological scores of treated group were significantly decreased compared with control. 4. PG contents in articular cartilages of the treated group were significantly increased compared with control. 5. TNF-α contents in synovial fluids of the treated group were significantly decreased compared with control. Conclusions : According to above results, Samgi-eum(Sanqi-yin) has anti-arthritic effects on the monosodium iodoacetate-induced osteoarthritis in rats. And it is related with reduced secretion of TNF-α from osteoarthritic chondrocytes and synovial membranes.
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