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원전 터빈사이클 성능 데이터의 검증 모델에 의한 성능분석 기법의 개발
김성근,최광희,Kim, Seong-Geun,Choe, Gwang-Hui 대한기계학회 2000 大韓機械學會論文集B Vol.24 No.12
Verification of measurements is required for precise evaluation of turbine cycle performance in nuclear power plant. We assumed that initial acceptance data and design data of the plant could provide correlation information between performance data. The data can be used as sample sets for the correct estimation model of measurement value. The modeling was done practically by using regression model based on plant design data, plant acceptance data and verified plant performance data of domestic nuclear power plant. We can construct more robust performance analysis system for an operation nuclear power plant with this validation scheme.
디젤엔진 관련 Soot 부착 및 재유입에 관한 화염에서의 연구
김성근,박종인,Kim, Seong-Geun,Park, Jong-In 대한기계학회 1996 大韓機械學會論文集B Vol.20 No.8
A study of soot deposition and reentrainment was carried out both theoretically and experimentally to understand behavior of soot formed by incomplete combustion in a diesel engine. Theoretically, soot deposition on engine cylinder wall and/or piston head was studied with a stagnation point flow approximation. Soot reentrainment occurred upon exhaust gas blowdown was also studied by assuming a long-normal shear velocity distribution. Experimentally, a LPG$O_2/N_2$ flame impinging on a disk, produced by a concentric tubular burner, was chosen as deposition configuration and a shear flow unit with compressed air was installed for the study of reentrainment. For selected flame configuration, soot deposition measurements were conducted and showed that the dominant deposition mechanism was thermophoresis. Distributions of gas temperature and soot number density were estimated by combining data obtained by a B-type thermocouple with a thermophoretic transport theory. Disk temperature distributions were directly measured using a K-type thermocouple. Soot size and morphology were estimated from a TEM photograph. Ratios of soot deposit to reentrained amount were measured for a wide range of shear flow velocities, which showed that the reentrainment model was reasonable.
Effect of NaCl on the Stability of Oncolytic Vaccinia Virus
Seong-Geun Kim(김성근),Gui Shao Ran(계소연),Hyuk-Chan Kwon(권혁찬),Tae-Ho Hwang(황태호) 한국생명과학회 2016 생명과학회지 Vol.26 No.1
Pexa-Vec (JX-594)은 암특이적 암용해 면역치료제인 백시니아 바이러스이다. 본 연구의 목적은 Pexa-Vec의 안정성을 극대화하기 위한 방법을 개발하는 것이다. 단기안정성 실험에서 바이러스의 활성은 4℃와 실온에서 감소하였으나, 초음파처리와 회전처리로 완전히 회복되었다. Pexa-Vec의 장기안정성 시험은 (A) 30 mM Tris/pH 7.6, (B) 30 mM Tris/pH 8.6, (C) 30 mM Tris/pH 7.6, 150 mM NaCl, 15% sucrose, (D) 30 mM Tris/pH 7.6, 15% sucrose, (E) 30 mM Tris/pH 8.6, 15% sucrose 조건 하에서 수행하였다. 제형 A는 4℃에서 4-8주 후, 실온에서 1주일 후에 2로그 이하로 바이러스활성이 감소되었다. 반면 제형 B의 경우 4℃와 실온에서 바이러스 활성이3일 후 감소되는 것으로 관찰되어 중성 산도가 바이러스 안정성을 유지하는데 필수적이다. 제형A에 15%의 슈크로즈 수크로오스를 추가했을 때(제형D), -20℃, 4℃와 실온에서 바이러스성 안정성이 크게 증가 하였고, 제형 E (pH 7.6)에서 다시 한번 확인되었다. 제형 D (pH 7.6)에 150 mM 염화나트륨을 추가한 제형 C에서 바이러스 안전성을 증가시키는 슈크로즈 수크로오스 효과를 더욱 향상시켜, 4℃와 실온에서 바이러스 활성이 각각 1.5년과 1-2주 동안 유지되는 결과를 보였다. 결론적으로, 우리는 제형C가 항암 백시니아 바이러스를 적절히 저장하기 위한 충분한 조건을 제공할 수 있다고 제안한다. Pexa-Vec (JX-594) is a specific cancer-targeted oncolytic and immunotherapeutic vaccinia virus. The purpose of this study was to develop methods to maximize the stability of Pexa-Vec. In short-term instability testing, viral activity was rapidly decreased both at 4°C and at room temperature (RT), but it was completely restored after sonication followed by vortex. Long-term stability testing of Pexa-Vec in the following liquid formulations was performed: (A) 30 mM Tris/pH 7.6, (B) 30 mM Tris/pH 8.6,(C) 30 mM Tris/pH 7.6, 150 mM NaCl, 15% sucrose, (D) 30 mM Tris/pH 7.6, 15% sucrose, and (E) 30 mM Tris/pH 8.6, 15% sucrose. Viral activity decreased less than 2 log10 at 4°C, and RT was observed in 3 days in B, while viral activity was not decreased even after 4–8 weeks at 4°C and at 1 week in RT in A, suggesting that neutral pH may be essential to maintain virus stability. The addition of 15% sucrose into A (D) significantly increased viral stability at -20°C, 4°C, or RT, and it was also observed at pH 8.6 (E). The addition of 150 mM NaCl into D (C) significantly increased viral stability in addition to the sucrose effect at 4°C or RT. Accordingly, the viral activity in formulation C was maintained for 1.5 years at 4°C, and for 1-2 weeks in RT. In conclusion, we propose that formulation C can provide the most adequate condition for the proper storage of vaccinia oncolytic virus.
사출성형 열가소성 폴리우레탄의 물리적 성질에 미치는 금형 온도 영향
김성근 ( Seong Geun Kim ),구엔빈칸 ( Vinh Khanh Nguyen ),이명걸 ( Ming Ji Lee ),방수진 ( Su Jin Pang ),이대수 ( Dai Soo Lee ) 한국고무학회 2004 엘라스토머 및 콤포지트 Vol.39 No.4
경도를 달리하는 에스테르계 및 에테르계 열가소성 폴리우레탄(thermoplastic polyurethane: TPU)의 사출에서 금형 온도가 물리적 성질에 미치는 영향을 조사하였다 TPU의 연질부 유리전이온도는 금형 온도 변화에 따라 거의 변화하지 않았으며, 연질부와 경질부의 상분리는 금형온도의 영향을 별로 받지 않는 것으로 판단되었다. 그러나 에스테르계와 에테르계 TPU는 종류에 관계없이 공통적으로 경도가 높은 TPU들은 금형온도를 높이는 경우 결정성, 고무상 평탄 온도영역, 인장강도가 감소하였으나, 경도가 낯은 TPU들은 오히려 결정성, 고무상 평탄 온도영역, 인장강도의 증가를 보였다. TPU의 사출 성형 금형 온도에 따른 물리적 성질의 차이를 결정성경질부의 결정화와 물리적 가교효과 차이로 해석하였다. Ester- and ether-based thermoplastic polyurethanes of different hardness were injection molded at different mold temperatures and effects of mold temperature on the physical properties of TPUs were investigated. Glass transition temperatures of soft segments of TPUs were hardly changed by mold temperatures. The phase separation of soft and hard segments of injection molded TPUs were affected little by mold temperatures. However, crystallinity of hard segments, temperature range of rubbery plateau, and tensile strength of injection molded TPUs decreased with increasing mold temperatures for TPUs of high hardness. However, injection molded TPUs of low hardness showed increases of crystallinity of hard segments, temperature range of rubbery plateau, and tensile strength with increasing mold temperatures. Different physical properties of injection molded TPUs depending on mold temperatures were attributed to different crystallization and physical crosslinking effects of hard segments.