http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
박창희,김록현,최재용,김미소,김태민,한일규,김종일,김한수 대한암학회 2024 Cancer Research and Treatment Vol.56 No.2
Purpose Brain metastasis rarely occurs in soft tissue sarcoma (STS). Here, we present five cases of STS with brain metastases with genetic profiles.Materials and Methods We included five patients from Seoul National University Hospital who were diagnosed with STS with metastasis to the brain. Tissue from the brain metastasis along with that from the primary site or other metastases were used for DNA and RNA sequencing to identify genetic profiles. Gene expression profiles were compared with sarcoma samples from The Cancer Genome Atlas.Results The overall survival after diagnosis of brain metastasis ranged from 2.2 to 34.3 months. Comparison of mutational profiles between brain metastases and matched primary or other metastatic samples showed similar profiles. In two patients, copy number variation profiles between brain metastasis and other tumors showed several differences including <i>MYCL, JUN, MYC</i>, and <i>DDR2</i> amplification. Gene ontology analysis showed that the group of genes significantly highly expressed in the brain metastasis samples was enriched in the G-protein coupled receptor activity, structural constituent of chromatin, protein heterodimerization activity, and binding of DNA, RNA, and protein. Gene set enrichment analysis showed enrichment in the pathway of neuroactive ligand-receptor interaction and systemic lupus erythematosus.Conclusion The five patients had variable ranges of clinical courses and outcomes. Genomic and transcriptomic analysis of STS with brain metastasis implicates possible involvement of complex expression modification and epigenetic changes rather than the addition of single driver gene alteration.
문대규,최현준,이학원,원종훈,김록현 순천향대학교 부설 산업기술연구소 2019 순천향 산업기술연구소논문집 Vol.25 No.1
Organic light emitting diodes (OLEDs) are one of the most promising technologies for general solid state lighting applications and flat panel displays. Because they offer many advantages of high resolution, low power consumption, large area display, thin film and flexibility. A thermal evaporation method has been mainly used as an organic thin film forming method. On the other hand, solution processes provide several advantages of low-cost and simple process and large area fabrication, We made thin films that are hole transport layer (HTL) and Emissive layer (EML) which is layer to combine electron and hole to use solution process. The poly-TPD was used as a HTL. Beacasue poly-TPD has a high hole mobility. The CBP used as a host of a EML doped with fluorescent dopant Rubrene. EML solution obtained by dissolving CBP : Rubrene in 4wt% and 8wt% of Tetrahydrofuran. As a result, driving voltage and current efficiency improved when applying HTL and the best device characteristics were confirmed when the dopant concentration was 4%.
IoT 기반 상·하지 재활의료기기 훈련이 후기 뇌졸중 생존자의 보행에 미치는 영향: 사례연구
성지원,조영채,서은영,김록현,윤범철 대한스포츠물리치료학회 2019 정형스포츠물리치료학회지 Vol.15 No.2
Purpose: For stroke survivors, abnormal gait patterns lead to a significant risk of falls. We have recentlydeveloped an IoT-based Upper and Lower Extremity Rehabilitation Medical Device (RoBoGat) that enablescontinuous passive motion (CPM) training, squat training (ST), and gait training (GT). The purpose of thisstudy was to test the effectiveness of RoBoGat on gait in a chronic stroke survivor. Methods: In this study, an individual with right-side chronic hemiparesis post-stroke participated. Theparticipant underwent 14 days of RoBoGat training that involved continuous passive motion training, squattraining, and gait training. During the training, knee and hip joint angles were adjusted within the range wherethe subject felt no pain. We assessed gait, timed up and go test, and visual analog scale at baseline andafter first and final interventions. Results: After the intervention, positive changes were observed such as stride, gait velocity, and loadingphase. Improvements were also observed in timed up and go tests. However, there was no significant changein VAS, which assessed pain in training and daily life. Conclusion: The main finding of this case-control study is that robot-based upper and lower extremity trainingmay be a feasible approach in the neurorehabilitation field. It can be concluded that repetitive and continuousrobot rehabilitation exercises have a positive effect on improving the physical function of chronic strokesurvivors.