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RISS 인기검색어
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- 저자 : 김기석(Kie Suck Kim) (검색결과 4 건)
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자궁내막증 치료 전후 환자의 혈청이 생쥐 난자의 수정률에 미치는 영향
김기석,민부기,이희섭,홍기연,이선영,박현진,김흥곤,Kim, Kie-Suck,Min, Bu-Kie,Rhee, Hee-Sub,Hong, Kie-Youn,Lee, Sun-Young,Park, Heon-Jin,Kim, Heung-Gon 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.3
Objective: To evaluate the effect of serum obtained before and after treatment for endometriosis on in vitro fertilization and development of two cell mouse embryo. Design: Pretreatment and posttreatment comparoson of fertilization of mouse oocyte and embryo development in serum supplement from patients with endometriosis; result were compared using Stuent T-test analysis. Method: Infertility Clinic, Department of Obstetrics and Gynecology, Collage of Medicine, Won kwang university, Korea. Patients was chosed eleven consecutive women with endometriosis. Interventions was all patient underwent laparoscopic or conservative surgery. This was followed by a 6-month course of burserelin acetate $900{\mu}g/d$. Main outcome was measured total number of fertilization and embryo that was fertilization after 24 hours and reached blastocyst stage after 72 hours of incubation were compared before and after treatment. Result: Before treatment, 47% of the oocyte were fertilized and 31% of the embryo reached blastocyst stage. After treatment, Significantly more fertilized and Significantly more embryo developed to blastocyst on the stage I and II of endometriosis. Conclusion: The fertilization and embryo toxicity of serum samples from patients with endometriosis is lost after treatment.
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폐경기 골다공증 여성에 있어서 Alendronate 치료에 대한 골교체의 생화학적 표지자의 평가
김기석(Kie Suck Kim),민부기(Bu Kie Min),이승필(Seung Fil Lee),김인숙(In Suk Kim),김훈영(Hun Young Kim),심재량(Jae Ryang Sim) 대한폐경학회 2000 대한폐경학회지 Vol.6 No.1
N/A Objectives: To evaluate the clinical utility of recently developed biochemical markers of bone turnover to monitor the response of osteoporotic patients to antiresorptive therapy, we compared the results of two advanced assays for markars of bone resorption and two of bone formation. Subjects and Methods: The rate of bone turnover in 37 women (mean±SD age, 58.2±4.5yr) with low boe mass and all postmenopausal women (mean±SD yr PMP, 8.3±5.2) was compared to that in 16 Premenopausal women(mean+SD age, 40.2±5.3yr) randomly selected from out-patient in our hospital and all have a normal spine bone mineral density(BMD). Perodically during the 12-month study,the level of several markers of bone turnover wen, measured. Serum osteocalcin, bone specific alkaline phosphatase mesured by RIA were used to assess bone formation. To assess bone resorption, we measured urinary excretion of Dedxypyridinoline, type l collagen cross-linked N- telopeptide, Result: All bone formation markers and all bone resorption marker were significantly increased in PMP Osteoporotic women. Under treatment with alendronate, resorption markers decreased earlier than marker of bone formation, Conclusion: This study, using biochemical markers of bone turnover, demonstrates that bone turnover is increased in PMP osteoporotic women. Alendronate treatment decreased bone turnover to the normal premenopausal range, with a steady state level reached after 1 month of therapy with 10mg for resorption markers and after 3-6 months of therapy for markers of bone formation.
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면역조직화학법에 의한 자궁경부암 및 자궁경부 상피내종양의 p53 단백검출
문형배,김기석,김흥곤,이희섭,홍기연,민부기,최기욱 대한부인종양 콜포스코피학회 1995 Journal of Gynecologic Oncology Vol.6 No.1
The cell cycle is composed of a series of steps which can be negatively or positively regulated by various factors. p53 gene aberrations are common in human malignancies, and recent studies suggest that in cervical carcinoma p53 function is inactivated either by complex formation with human papilloma virus (HPV) E6 product or by gene mutation. To study the expression of p53 gene in the cervical cancer and cervical intraepithebal neoplasia, immunohistochemistry for the p53 protein was done in the 47 cases of squamous cell carcinoma, 6 cases of adenocarcinoma and 32 cases of cervical intraepithelial neoplasia. 1. The p53 protein was detected in the 31% of cervical intraepithelial neoplasia (10/32 cases). 2. The p53 protein was detected in the 55% of invasive cervical cancer (29/53 cases). 3. By the histologic type of cervical cancer, the p53 protein was detected in the 57% of squamous cell carcinoma (27/47 cases) and 33% of(2/6 cases) adenocarcinoma. The p53 protein wes more frequently detected in the squamous cell carcinoma than in the adenocarcinoma. 4. By the staging in cervical cancer, the p53 protein was detected in the 31% of stage 0, 50% of Stage Ia, 50% of stage I b, 75% of IIa and 50% of stage IIb.
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호르몬 보충용법이 단구세포의 조직인자 활동에 미치는 영향
민부기,김홍곤,김기석,홍기연,이희섭 대한폐경학회 1998 대한폐경학회지 Vol.4 No.1
"Our purpose was to investigate the effects of hormone replacement therapy on the reactivity of monocyte in whole blood, mesured by tissue factor activity. Thirty-eight women were randomized into oral combind homone replacement therapy and underwent blood sampling before and 3 and 12 months of treament,The tissue factor activity in monocytes was measured both in unstimulated whole blood and after a weak lipopolisaccaide stimulation. After 12months of hormone replacement therapy there were significant reduction of tissue factor activity in both unstimulated and lipopolisaccaride stimulated monocyte (p<0.001). Twelve months of hormone replacement therapy reduces cellular activation of blood monocytes; these changes may account for some of the beneficial effects in reducing the risk of cardiovascular disease. "
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