스틸렌 - 아크릴산계 공중합체의 금속착물 형성에 관한 연구

김공수,김수종,조석형,전용철 ( Kong Soo Kim,Soo Jong Kim,Suk Hyeong Cho,Yong Chul Chun ) 한국공업화학회 1991 공업화학 Vol.2 No.1

수용성 poly(sulfonated styrene-co-acrylic acid)를 합성하여 Cu(II)이온과의 착물형성에 관한 연구를 수행하였다. poly(sulfonated styrene-co-acrylic acid)-Cu(II)착물의 생성반응에 있어서 pH 변화에 따른 UV-Vis.흡수 스펙트라 및 점도 특성을 시험하여 착물형성조건을 검토하였다. 또한, poly(sulfonated styrene-co-acrylic acid)-Cu(II) 착물의 생성상수와 안정도상수를 Bjerrum 방법으로 구하였고 Ringbom 방법으로 착물생성 엔탈피, 자유에너지 및 엔트로피 변화 등 열역학적 특성값을 구하였다. Water soluble poly(sulfonated styrene-co-acrylic acid) was polymerized with sulfonated styrene and acrylic acid in the presence of silver sulfate at 99 ℃ for 4 hrs. The complex formation of poly(sulfonated styrene-co-acrylic acid) with Cu(II) was carried out. The maximum absorption wavelength of the poly(sulfonated styrene-co-acrylic)-Cu(II) system at different pH values was observed at 274 nm and 295 nm. The reduced viscosity of the poly(sulfonated styrene-co-acrylic acid)-Cu(II) complex were measured in the various pH ranges. The formation constants and stability constants of poly(sulfonated styrene-co-acrylic acid)-Cu(II) complex were calculated from Bjerrum method. The changes of enthalpy, free energy and entropy in the above reaction were determined by Ringbom method.

Chitosan - g - Poly ( 4- vinyl pyridine ) 공중합체막을 통한 인슐린의 투과 특성

김공수,강석호,김수종,임정규 ( Kong Soo Kim,Seog Ho Kang,Soo Jong Kim,Jeong Kyu Lim ) 한국공업화학회 1994 공업화학 Vol.5 No.4

Chitosan-g-Poly(4-vinyl pyridine)공중합체막을 제조하였으며 Chitosan-g-Poly(4-vinyl pyridine)공중합체막과 아크릴아마이드를 사용하여 glucose oxidase를 포함하는 chitosan/acrylamide 복합막을 제조하였다. Chitosan-g-poly(4-vinyl pyridine)공중합체막의 함수율과 인슐린의 투과량은 용액의 pH가 감소함에 따라 증가하였고, 복합막의 인슐린 투과량은 글루코오스의 농도가 증가할수록 증가하였다. Chitosan-g-poly(4-vinyl pyridine)membranes were prepared by crosslinking reaction using glutaraldehyde and glucose oxidase immobilized chitosan/acrylamide composite membranes were fabricated by chitosan-g-poly(4-vinyl pyridine) copolymer and acrylamide. Water content and permeability of insulin through chitosan-g-poly(4-vinyl pyridine)membranes increased with decreasing the pH of the medium Permeability of insulin through chitosan/acrylamide composite membranes increased with increasing the concentration of glucose.

Dipping 법에 의한 천연고무와 그라프트 라텍스 블렌드 필름의 표면특성

김공수,박준하,엄주송 ( Jun Ha Park,Kong Soo Kim,Ju Song Eum ) 한국공업화학회 1994 공업화학 Vol.5 No.6

천연고무 라텍스(NRL)와 메틸메타 크릴레이트가 그라프트된 라텍스(MGL)를 각종 첨가제와 혼합하여 dipping 공정으로 가황된 NR 및 블렌드 필름을 제조하였다. NR 필름 제조의 최적조건을 규명하기 위하여 숙성시간에 따른 팽윤도, 인장강도 및 110℃에서 가황시간의 변화에 따른 기계적 특성을 비교하였다. 필름 표면의 구조 및 미끄럼성을 조사하기 위하여 접촉각 및 정·동마찰계수를 측정한 결과, 접촉각은 MGL의 블렌드 비율이 증가할수록 감소하였고, 정 및 동마찰계수는 NR 필름에 비하여 NR/MG 과 NR-d-MG 필름이 현저히 감소하여 표면 미끄럼성이 향상됨을 알 수 있었다. The vulcanized NR and blend films were prepared with mixing of natural rubber latex (NRL) and methyl methacrylated grafted latex(MGL) with various additives by dipping process. It was investigated the basic properties of vulcanized NR films that is optimum condition of the mature time, swelling degree, cure time at 110℃, and measured the mechanical properties of tensile strength and elongation of its condition. In order to identify the surface structure and the slip properties of blend films, contact angles and static and kinetic friction coefficient were measured. Contact angles were decreased with increment of blend ratio of MGL, and static and kinetic friction coefficient were decreased rapidly for the NR/MG and NR-d-MG films than for the NR films. From the results, NR/MG and NR-d-MG films has slip`s reinforcement in skin contact surface with increased of blend ratio of MGL.

Poly ( caprolactone diol ) 을 기초로 한 Polyurethane Microgels 의 합성과 특성

김공수,이무재 ( Kong Soo Kim,Moo Jae Lee ) 한국공업화학회 1997 한국공업화학회 연구논문 초록집 Vol.1997 No.0

다공성 고분자 마이크로겔의 Bovine Serum Albumin 단백질의 흡착평형

김공수,강석호 ( Kong Soo Kim,Seog Ho Kang ) 한국공업화학회 1998 공업화학 Vol.9 No.2

물리·화학적인 특성이 다른 다공성 고분자 마이크로겔에 대한 bovine serum albumin(BSA-protein) 단백질의 흡착평형 특성을 연구하였다. 수용액 속에서 고분자와 단백질사이의 소수성 상호작용에 의하여 폴리부틸메타크릴레이트(PBMA) 마이크로겔이 폴리비닐피리딘 (PVP)과 플리아크릴로니트릴 (PAN) 마이크로겔보다 높은 흡착특성을 나타내었으며, PBMA 마이크로겔이 PVP와 PAN 마이크로겔보다 비가역적으로 흡착평형 특성을 나타내었다. 그러므로 고분자 마이크로겔의 물리적인 특성과 단백질-고분자 마이크로겔 사이의 정전기적 인력보다는 소수성 상호작용이 단백질의 흡착특성에 중요한 역할을 하고 있음을 알 수 있다. 또한 PBMA, PVP 및 PAN 마이크로겔 모두 Freundlich 흡착 등온식보다는 Langmuir 흡착 등온식에 잘 적응되었다. The adsorption equilibrium properties of bovine serum albumin(BSA-protein) for three kinds of porous microgels with different physical and chemical features were investigated. The adsorption amount of BSA-protein on poly(butyl methacrylate) (PBMA) microgels was higher than those on poly(vinyl pyridine) (PVP) and poly(acrylonitrile) (PAN) microgels due to the hydrophobic interaction between polymer and protein in an aqueous solution. And PBMA microgels had more irreversible adsorption equilibrium properties than PVP and PAN microgels. It implies that hydrophobic interaction plays a more important role in adsorption properties of BAS-protein than physical properties of polymer and electrostatic attraction between protein and polymer microgels. Characteristics of the microgels used in this study followed Langmuir equation better than the Freundlich equation.

생분해성 Microgel 로부터 약물을 담지한 Microsphere 의 제조 및 그의 생분해성

김공수,강석호,김정묵 ( Kong Soo Kim,Seak Ho Kang,Jeong Muk Kim ) 한국공업화학회 1998 공업화학 Vol.9 No.4

술중 심정지에 대한 심소생 치료

김공수,Kim, Kong Soo 대한흉부심장혈관외과학회 1976 Journal of Chest Surgery (J Chest Surg) Vol.9 No.1

This is a report of 8 cases cardiac arrest developed in the operating room at Jeonbug university Hospital from January 1973 to October, 1975. Four patients of cardiac arrest developed during the elective operation, 3 during the emergency operation and the remaining one, bronchoscopy for foreign body removal under the general anesthesia. Immediate closed chest cardiac massage was performed in the 7 patients and the remaining one underwent open chest cardiac massage. Five of 7 patients with the closed chest cardiac massage regained consciousness and restored respiration, but 3 patients of these survived to be discharged. Two patients who underwent pneumonectomy for multiple lung abscess and open drainage for liver abscess, were resuscitated but did survived. The Latter died from bleeding due to rupture of the liver that developed during the closed chest cardiac massage. One patient who had open chest cardiac massage survived to be discharged without any sequele. Unsuccessful resuscitation was observed in two patients, one had a complication of malignant hyperthermia with muscle rigidity during gastrectomy for ulcer perforation and another had not firm support on the back during massage.

크로마토그래피용 고분자 겔의 제조 및 분리특성

김공수,강석호,박명환,이상호 ( Kong Soo Kim,Seog Ho Kang,Myung Hwan Park,Sang Ho Lee ) 한국공업화학회 1994 공업화학 Vol.5 No.6

분산중합으로 합성한 폴리스티렌 seed를 사용하여 seed 중합방법으로 단분산성인 다공성 스티렌-디비닐벤젠(St-DVB) 겔과 아크릴로니트릴-에틸렌 디메타크릴레이트(AN-EDMA) 겔을 제조하였다. 합성한 St-DVB 겔과 AN-EDMA 겔은 HPLC용 충진제로 적합한 좁은 입도분포와 다공성을 갖고 있으며, 이들 겔을 충진한 GPC 또는 HPLC용 column은 비교적 높은 효율을 나타내었다, 또한 AN-EDMA 겔을 아미드옥심화한 AAN-EDMA 겔에 대한 Cu^(2+) Cd^(2+) 및 UO₂^(2+) 이온의 흡착특성을 시험하였다. Monodisperse porous poly(styrene-co-divinylbenzene)(St-DVB) gel and poly(acrylonitrile-co-ethylene dimethacrylate)(AN-EDMA) gel have been prepared by seed polymerization using polystyrene seeds, which were prepared by dispersion polymerization. The St-DVB and AN-EDMA gels had a narrow size distribution and pores suitable for packing materials of HPLC. The columns packed with these gels were proved to have high efficiency for GPC or HPLC columns. Adsorption properties of Cu^(2+), Cd^(2+) and UO₂^(2+) ions on AAN-EDMA gel prepared from amidoximation of AN-EDMA gel were also determined.

허혈성 자극에 의한 심방이뇨 호르몬 분비 반응의 특성

김공수,김민호,김창곤,김석기,조경우,최훈,Kim, Kong-Soo,Kim, Min-Ho,Kim, Chang-Gon,Kim, Suk-Kee,Cho, Kyung-Woo,Cui, Xun 대한흉부심장혈관외과학회 2000 Journal of Chest Surgery (J Chest Surg) Vol.33 No.5

Background: Cardiac atrium is an endocrine gland secreting a family of natriuretic peptides. The secretion of atrial natriuretic peptide(ANP) had been shown to be controlled by variable factors. The change in atrial dynamics have been considered as one of the most prominent stimuli for the stimulation of ANP secretion. Hypoxic stress has been shown to increase cardiac ANP secretion. However, the mechanism by which hypoxia increases ANP secretion cardiac ANP secretions. However, the mechanism by which hypoxia increases ANP secretion has not to be defined. Therefore, the purpose of the present study was tow-fold: to develop a protocol to defined the effect of hypoxia on ANP secretion in perfused beating rabbit atria and to clarify the mechanism responsible for the accentuation by hypoxia of ANP secretion. Material and Method: Experiments have been done in perfused beating rabbit atria. ANP was measured by radioimmunoassay. Result: Hypoxic stimulus with nitrogen decreased atrial stroke volume. The decrease in atrial stroke volume recovered basal level during the period of recovery with oxygen. ANP secretion and the concentration of perfusate ANP in terms of extracellular fluid(ECF) translocation which reflects the rate of myocytic release of ANP were increased by hypoxia and returned to basal levels during the recovery. Changes in ECF translocation paralleled by hypoxia and returned to basal levels during the recovery. Changes in ECF translocation paralleled to that of atrial stroke volume. At the start of recovery in atrial storke volume, ECF tranalocation incrased for several minutes. The above responses were stable and reproducible. Glibenclamide treatment prevented the recovery in atrial stroke volume. Increments by hypoxia of ANP secretion and ANP concentration were suppressed by glibenclamide. Conclusion: These results indicate that hypoxia incrased atrial myocytic ANP release and that the mechanism responsible for the accentuation is partially related to the change in K+ATP channel activity.

포스터 발표 - 고분자공업분과 : Poly ( caprolactone diol ) 을 기초로 한 Polyurethane Microgels 의 합성과 특성

김공수,이무재 ( Kong Soo Kim,Moo Jae Lee ) 한국공업화학회 1997 한국공업화학회 연구논문 초록집 Vol.1990 No.3