지황 추출물 첨가 chitosan 기반 기능성 바이오 소재 제조 및 응용

이시연,김경중,김윤섭,윤순도,Lee, Si-Yeon,Kim, Kyeong-Jung,Kim, Youn-Sop,Yoon, Soon-Do 한국공업화학회 2022 공업화학 Vol.33 No.2

The main objective of this work is to prepare Rehmannia glutinosa extract (RE) incorporated functional chitosan (CH) based biomaterials and evaluate their physical properties, RE release properties, inhibitory effect of melanogenesis, and antioxidant and elastase inhibitory activities. RE incorporated CH based biomaterials were synthesized by a casting method and UV curing process. The surface and cross sections of prepared biomaterials were characterized by a field emission scanning electron microscope (FE-SEM). The physical properties such as tensile strength and elongation at break were also investigated. To apply the transdermal drug delivery system, RE release properties were examined with pH 4.5, 5.5, and 6.5 buffer solutions and artificial skin test at 36.5 ℃. Results indicated that RE release of RE incorporated biomaterials with/without the addition of plasticizers [glycerol (GL) and citric acid (CA)] at pH 6.5 was about 1.10 times higher than that of at pH 4.5. In addition, results of the artificial skin test verified that RE was released constantly for 6 h. To verify the applicability of the prepared biomaterials, tyrosinase, 2,2-diphenyl-1-picrylhydrazyl (DPPH), and elastase assays were investigated. Results indicated that RE incorporated biomaterials added CA exhibited tyrosinase activation, DPPH radical scavenging activity rate, and elastase activation of 45.12, 89.40, and 59.94%, respectively.

고혈압성 심장에서 4 심음과 좌심실 근질량 및 승모판 혈류양상의 관계

정양호(Yang Ho Jung),김경중(Kyeong Joong Kim),허종(Jong Heo),노인환(In Whan Ro),박양규(Yang Kyu Park),정진원(Jin Won Jeong),박옥규(Ock Kyu Park) 대한내과학회 1989 대한내과학회지 Vol.37 No.6

N/A To determine the clinical significance of the fourth heart sound (S.) in hypertensive heart, 31 patients with essential hypertension aged between 32 to 77 years old and 15 normal controls were examined by physical examination, phonocardiography and echocardiography, All hypertensive patients had normal sinus rhythm and no history of coronary artery disease nor COPD and most of them had moderate to severe hypertension. Depending upon the presence of audible S4, hypertensive patients were divided into 3 groups; those without audible S, (group I, 15 cases), those with audible S, (group II, 12 cases) and those with questionably audible S, (group III, 4 cases). M-mode echocardiograms of the left ventricle and pulsed wave Doppler echocardiograms of the mitral valve were performed to determine the left ventricular thickness/dimension ratio (T/D), left ventricular mass index (LVMI) and A/E ratio of mitral flow pattern. T/D and LVMI were significantly increased in both hypertensive group I and group 11 (p<0.01) and T/D of hypertensive group II was more increased than that of hypertensive group I (p<0,05), but there was no significant difference between hypertensive group I and group II in LVMI. In contrast, the A/E ratio of mitral Doppler flow pattern was increased only in hypertensive group II compared to normal controls (p<0.01), and there was a significant difference between hypertensive group I and group II (p<0.01). Audible S, was found in hypertensive patients with an A/E ratio greater than 1.10 and in a normal person with an A/E ratio of 1.27, and all 10 hypertensive patients above an A/E ratio of 1.20 except one had an audible fourth heart sound. In conclusion, audible fourth heart sound is a useful bedside parameter for detecting left ventricular diastolic dysfunction in the hypertensive heart.

경피약물전달을 위한 아세트아미노펜 각인 기능성 전분 기반 바이오 소재 제조 및 방출 특성

김한성 ( Han-seong Kim ),김경중 ( Kyeong-jung Kim ),이시연 ( Si-yeon Lee ),조은비 ( Eun-bi Cho ),강현욱 ( Hyun-wook Kang ),윤순도 ( Soon-do Yoon ) 한국공업화학회 2021 공업화학 Vol.32 No.3

본 연구에서는 mung bean starch (MBS), polyvinyl alcohol (PVA), sodium benzoate (S), glycerol (GL), melanin (MEL)을 이용하여 광열 효과가 있는 기능성 acetaminophen (AP) 각인 MBS 기반 바이오 소재를 제조하고 약물 방출 특성을 조사하였다. 제조된 AP 각인 바이오 소재의 물리화학적 특성은 FE-SEM과 FT-IR을 통해 분석하였다. 또한, NIR (near infrared) laser (1.5 W/㎠) 조사에 따른 기능성 바이오 소재의 광열 효과 및 AP 방출 특성을 조사하였다. 바이오 소재에 NIR laser를 조사하였을 때, MEL이 첨가 바이오 소재는 첨가하지 않은 바이오 소재보다 2배 이상 높은 온도상승을 보였다. 표준 버퍼 용액과 인공 피부를 사용하여 기능성 AP 각인 바이오 소재의 AP 방출 특성 조사결과, NIR laser를 조사하였을 때, MEL 첨가 바이오 소재는 첨가하지 않은 바이오 소재보다 AP 방출율이 1.2배 높은 것을 확인하였다. 이 결과로부터, 기능성 바이오 소재는 급성 진통 치료를 위한 바이오 소재로 활용될 수 있을 것으로 판단된다. This study focuses on the preparation of acetaminophen (AP) imprinted functional biomaterials for a transdermal drug delivery using mung bean starch (MBS), polyvinyl alcohol (PVA), sodium benzoate (S) as a crosslinking agent, glycerol (GL) as a plasticizer, and melanin (MEL) as a photothermal agent. The prepared AP imprinted biomaterials were characterized using FE-SEM and their physical properties were evaluated. The photothermal effect and AP release property for functional biomaterials were examined with the irradiation of near infrared (NIR) laser (1.5 W/㎠). When the NIR laser was irradiated on functional biomaterials with/without the addition of MEL, the temperature of MEL added biomaterial increased from 25 ℃ to 41 ℃, whereas the biomaterial without MEL increased from 25 ℃ to 28 ℃. Results indicate that there is the photothermal effect of prepared biomaterial with the addition of MEL. Based on the results, AP release properties were evaluated using standard buffer solutions and artificial skin. It was found that AP release rates of MEL added AP loaded biomaterials were 1.2 times faster than those of MEL non-added AP loaded biomaterials when irradiating with NIR laser. We envision that the developed functional biomaterials can be utilized for an acute pain-killing treatment.

증례 : Praziquantel 투여로 호전된 뇌낭미충증 2 예

이영 ( Yung Lee ),김자천 ( Ja Cheon Kim ),손희철 ( Hie Chul Son ),김경중 ( Kyeong Jung Kim ),박재웅 ( Jae Ung Park ),지무영 ( Mu Yeong Chi ),임종윤 ( Cheong Yun Rim ) 대한내과학회 1985 대한내과학회지 Vol.29 No.5

페미니즘 관점에서 본 아동문학

김경중 한국여성문학학회 2001 여성문학연구 Vol.6 No.-

필자는 페미니즘을 다음의 세 가지 측면으로 간주하였다. 첫째는 여성의 성적 소외, 불안, 갈등, 억압으로부터의 해방이며, 둘째는 여성의 성 정체성 형성이고, 셋째는 여성의 성평등과 수월성 추구이다. 한편 아동문학에 대한 네 가지 준거는, 아동을 위해 쓰여진 문학, 아동에 적합한 것으로 인식된 문학, 아동에 의해 수용된 문학, 행위 및 상징체계로서의 문학이다. 이같은 준거에 의해 다음과 같은 과정으로 아동문학에 나타난 페미니즘적 요소들을 분석하였다. 1. 전래동화에 투영된, 현실원칙과 쾌락의 원칙에 나타난 여성 2. 남녀의 균형적인 성역할 모델 3. 이니시에이션과 여성의 성적 성숙 4. 한국 전래동화에 나타난 남녀의 성대결 5. 안데르센 동화에 나타난 페미니즘 6. 동시에 나타난 페미니즘 이같은 분석을 통해서 나타난 결과는 다음과 같이 요약된다. 첫째 전래동화 속에는 여성의 성적 소외, 불안, 갈등, 억압으로부터의 해방을 도와 줄 수 있는 내용이 많다. 둘째 전래동화 속에는 성장기 아동이 겪게 되는 격리불안의 문제를 많이 다루고 있는데 이때 불안의 근원은 대부분 모성으로부터의 분리이다. 셋째 전래동화의 주요내용은 이니시에이션(initiation)의 과정을 보여주고 있는데 이 과정에서 여성의 탄생과 성적 성숙, 성적 정체성을 극명하게 보여 주고 있다. 넷째 안데르센의 창작동화나 동시에 나타난 여성은 성의 평등과 정체성은 물론 여성의 수월성을 분명하게 잘 보여주고 있다. 다섯째 페미니즘 관점에서 아동문학은, 여성의 성적 소외, 불안, 갈등, 억압으로부터의 해방, 여성의 성 정체성 형성, 여성의 성평등과 수월성 추구 등의 내용을 보편적으로 추구하고 있다. We considered Feminism as the following three parts: First, a freedom from sexual alienation, anxiety, complex and oppression in women. Second, a formation of sex identification of women. Third, a sex equality of women and a pursuit of superiority. On the one hand, the four criterions are the literature written for children, the recognized literature suitable for children, the literature received by children and the literature for a system of behavior and symbol. We analysed Feminism the following courses by these criterions: 1. the woman presented with the principle of reality and pleasure projected by traditional fairy tale 2. the sexual-role model balanced by man and woman 3. the initiation and the sexual maturation of women 4. sexual confrontation presented by traditional fairy tale in Korea 5. the Feminism presented in Andersen fairy fale 6. the Feminism presented in children's verse We summed up the result presented through this analysis as follows: 1. There are a plenty of contents which can help them a freedom from sexual alienation, anxiety, complex and oppression in women traditional fairy tale in Korea. 2. The Korean traditional fairy tale treats the isolated-anxiety problems which growth-period children suffered. Here, the sources of anxiety are, for the most part, the separation from motherhood. 3. The main content of traditional fairy tale in Korea is that presents the course of initiation. This course shows most clearly a birth of woman, sexual maturation and sexual identity. 4. Andersen's creative fairy tale and female emerging at the same time shows clearly woman's superiority as well as sexual equality and identity. 5. In view of Feminism, children literature pursuits universally a content of a freedom from sexual alienation, anxiety, complex and oppression in women, a formation of sex identification of women, a sex equality of women and a pursuit of superiority, etc.