Diphenylcyclopropenone ( DCP ) 면역요법으로 치료한 HPV 16형 양성 Bowen 양 구진증 2예

권윤희 ( Yoon Hee Kwon ),이종육 ( Tae Yoon Kim ),김태윤 ( Jong Yuk Lee ),김정원 ( Chung Won Kim ),박종섭 ( Jong Sup Park ),김승조 ( Seung Jo Kim ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.1

Bowenoid papulosis(BP) is characterized by multiple papules with a benign clinical course but having a histopathology of squamous cell carcinoma in situ on the external genitalia of sexually active men and women. It is well known that the Human papilloma virus(HPV) is connected with the development of BP. Out of these, HPV 16 which has been frequently found in the BP lesions is an oncogenic virus and the theory that BP might progress to intraepithelial neoplasia and advanced carcinoma has been postulated. Local destructive therapy including electrodessication, laser surgery, cryosurgery, and surgical excision is effective and produces a low recurrence rate. However, pain, bleeding, restriction in activity, and postoperative scars are inevitable with complete destruction of the multiple lesions. It has been suggested that diphenylcyclopropenone(DCP) might be a promising therapeutic agent for various viral diseases including HPV-related warts, It is a potent sensitizer which is not mutagenic and works by the induction of type IV hypersensitivity response in HPV infected tissue, leading to wart destruction. We herein, report 2 cases of HPV 16-positive BP treated with DCP immunotherapy. (Kor J Dermatol 1996;34(1): 190-1B5)

조갑진균증의 진단에 있어 KONCPA 검사의 임상적 의의

권윤희 ( Yoon Hee Kwon ),조백기 ( Baik Kee Cho ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.4

Background: It has been reported that KONCPA(KOH+Nail clipping+PAS reaction) test might be a useful complementary method with a high positive rate and an exellent view for making the diagnosis of onychomycosis. Objective : This study was aimed to know whether KONCPA test would increase the diagnostic sensitivity of onychomycosis, and agree with the findings of fungus culture and whether KONCPA finding would be of help in diagnosing the causative fungi even in case that KOH smear and fungus culture fail to identify the causative fungi. Methods : Using 95 onychomycotic nail samples obtained from 87 patients, the KONCPA findings were compared with those of KOH smear and fungus culture. Results : The results were as follows ; 1. The positive rates for dtecting the causative fungi from KOH srnear, fungus culture and KONCPA test were 77.9%, 45.3% and 95.8% respectively. The time required for KONCPA test, showing the highest positive rate, was only about 2 to 3 hours. 2. The fungus culture identified the causative fungi from 43 samples, of which dermatophytes were found in 31 samples(72.1%), Candida spp. in 5 samples(11.6%) and molds in 7 samples(16. 3%). KOH smear revealed the causative fungi in 63 samples : dermatophytes 56(88.9%), Candida spp. 4(6.3%) and molds 3(4.8%). KONCPA yielded the highest positivity by detecting the pathogenic fungi in 86 samples(95.8%): dermatophytes 60(69.8%), Candida spp. 8(9.3%), molds 10 (11.6%) and mixed infections 8(9.3%). 3. Compared with the results of fungus culture, 3 groups of fungi showed morphologic differences on KONCPA test: dermatophyte showing septated long and thin hyphae and a few arthrospores, Candida sp. showing blastospores and/or grape-like clusters of regular spores and pseudohyphae, and mold showing irregular hyphae with variable width and aggregates of irregular spores. 4. Of the 52 samples which were negative in fungus culture, 33(63.5%) showed findings of dermatophyte, 2(3.8% ) of Candida sp., 2(3.8% ) of mold and the remaining 11 samples(21.2% ) were negative on KOH smear, Of these 52 samples, KONCPA diagnosed 34(65.4%) to be dermatophytes, 6(11.5%) Candida syp., 6(11.5%) molds, 1(1.9%) mixed infection and 2 samples(3.8%) to be negative. Conclusion : KONCPA test is useful in the diagnosis of onychomycosis because of its higher positive rate in detecting the causative fungi compared with fungus culture or KOH smear. It is also a timesaving and simple procedure. Furthermore, in case that KOH smear and fungus culture fail to identify the causative fungi, it is possible to make a presumptive diagnosis by the findings of KONCPA test. (Kor J Dermatol 1996;34(4): 527-537)

Thymopentin 투여로 치료한 단순포진 연관 다형홍반

권윤희 ( Yoon Hee Kwon ),박철종 ( Chul Jong Park ),김형옥 ( Hyung Ok Kim ),김정원 ( Chung Won Kim ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.1

Herpes-associated erythema multiforme(HAEM) is a common subtype of erythema multiforme (EM) which usually develops 1-3 weeks after the recurrent herpetic episodes. The role of HSV in the pathogenesis of EM has not been fully defined. Recent studies, however, suggest that the host immune response to HSV, especially cell-mediated immune mechanism, is critical to the development of HAEM and, based on these findings, a variety of immunomodulating agents have been tried for the treatment of recurrent EM. Thymopentin, an immunomodulator that influences the maturation of thymocyte and mature T cell function, has been used as a therapeutic agent for various autoimmune diseases and recurrent HSV infection. A 37-year-old man with HAEM, who had failed to respond to intermittent acyclovir therapy for about 5 years, was treated with a subcutaneous injection of thymopentin 50mg three times a week for 6 consecutive weeks. The EM lesions were completely cleared 5 weeks after starting the treatment, without any sigrificant side effects. We herein, report a case of HAEM who has been treated with a 6-week schedule of thymopentin therapy and has showed no recurrence for the 6 months of follow-up period. (Kor J Dermatol 1996;34(1): 141-146)

Emamectin benzoate와 Pyridaben의 잔효성에 따른 담배가루이의 섭식행동 변화

권윤희(Yun-Hee Kwon),양정오(Jeong-Oh Yang),오정훈(Jeong-Hoon Oh),노두진(Doo-Jin Noh),윤창만(Changmann Yoon),김길하(Gil-Hah Kim) 한국농약과학회 2008 농약과학회지 Vol.12 No.4

EPG 파형과 감로 분비, 미세절편 관찰로 해석된 애멸구의 벼 섭식행동

서보윤,권윤희,정진교,김길하,Seo, Bo Yoon,Kwon, Youn-Hee,Jung, Jin Kyo,Kim, Gil-Hah 한국응용곤충학회 2016 한국응용곤충학회지 Vol.55 No.4

DC-EPG 시스템을 활용하여 애멸구(Laodelphax striatellus) 암컷 성충이 벼를 섭식하는 동안 발생되는 전기적 신호를 기록하고 분석하여, 벼멸구에서 보고된 것(Seo et al., 2009)과 같은 방식으로, np, L1, L2, L3, L4-a, L4-b, L5의 7 개 EPG 파형으로 구별하였다. 파형들의 모양과 발생 패턴은 벼멸구(Nilaparvata lugens)와 매우 유사하였고, L4-b의 직전에는 반드시 L3와 L4-a가 연속된 순서로 나타났다. 감로는 L4-b에서 주기적으로 분비되었다. 레이저 stylectomy 후 섭식부분의 미세절편을 관찰한 결과, 애멸구 구침의 끝이 L3와 L4-a, L4-b에서는 벼의 체관부 근처 또는 체관부에서 관찰된 반면, L5에서는 물관부에서 관찰되었다. 레이저 stylectomy로 L4-b에서 잘려진 애멸구 구침의 절단부로부터 유일하게 벼수액이 용출되었고, HPLC로 분석된 수액 안의 당 성분으로 식물의 체관부 탄수화물 이동태인 설탕(sucrose)만이 검출되었다. 이상의 관찰 결과와 애멸구의 EPG 파형 전개 과정 분석을 통해, L1과 L2는 관다발 도달 전에 발생하는 구침을 찌르고 타액 분비가 동반된 구침의 이동 행동으로, L3와 L4-a는 체관부에서 섭식을 위해 사전에 준비하는 과정으로, L4-b는 체관부 수액을 흡즙하는 행동으로, 마지막으로 L5는 물관부에서 형성되는 섭식행동으로 벼멸구와 유사하게 결론지었다. Consistent with a previous study on the brown planthopper Nilaparvata lugens (BPH) (Seo et al., 2009), we identified seven distinct EPG waveforms (np, L1, L2, L3, L4-a, L4-b, and L5) in adult female Laodelphax striatellus (SBPH) that fed on rice plants, by using the direct current electrical penetration graph (DC-EPG) system. The shape of waveforms and the pattern of occurrence of each waveform of SBPH were very similar to those of BPH. L3 and L4-a always occurred prior to L4-b. Periodical honeydew excretion was observed in L4-b only. Microsection observation following laser stylectomy revealed that the tips of SBPH stylets severed in L3, L4-a, and L4-b were commonly located in or near the phloem region of rice plants, but were located in the xylem in L5. Plant sap flowed from the stylets severed in L4-b only, and its main carbohydrate component was detected as sucrose by HPLC analysis. These results and the patterns of EPG waveform progress in SBPH suggested that feeding activities on rice plant tissue were relevant to each EPG waveform. L1 and L2 corresponded to the initiation of stylet penetration and stylet movement with salivation on the outside of the vascular bundle. L3 and L4-a were related to feeding activities within the phloem region in preparation for phloem sap ingestion. L4-b was closely associated with phloem sap ingestion, and L5 corresponded to xylem feeding behavior.

특발성 골수섬유증을 동반한 괴저성 농피증

최태진,권윤희,윤두희,김태윤,김정원 ( Tae Jin Choi,Yoon Hee Kwon,Dou Hee Yoon,Tae yoon Kim,Chung Won Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4

Pyoderma gangrenosum is a rare, recurrent, painful and ulcerative skin disorder of unknown etiology, but is commonly associated with a variety of underlying systemic diseases of ulcerative colitis, rheumatoid arthritis, monoclonal gammopathies, Crohns disease, chronic active hepatitis and some hematologic diseases such as leukemia, thrombocythemia, dysglobulinemia and myeloma. We describe a 50 year-old woman who had pyoderma gangrenosum associated with idiopathic myelofibrosis. The findings of a bone marrow biopsy revealed proliferation of fibroblasts and a dense reticulin network, which were consistent with myelofibrosis. Steroid therapy resulted in a good response temporarily but, she died within a year after diagnosis. To our knowledge, our present case associated with idiopathic myelofibrosis is the first reported case in the Korean literature. (Kor J Dematol 1997;35(4): 781-785)

정상 혈중 아연농도를 보인 장병성 선단 피부염

김태윤 ( Tae Yoon Kim ),권윤희 ( Yoon Hee Kwon ),이동원 ( Dong Won Lee ),백승철 ( Seung Churl Baek ),조백기 ( Baik Kee Cho ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.6

Acrodermatitis enteropathica is a rare autosomal recessive disorder characterized by alopecia, a ral and periorificial derma.titis and gastro-intestinal disturbances such as diarrhea. This syndrome is caused by malab, orption of zinc. The mean serum zinc level is usually low in untreated patients and the oral administration of zinc sulfate can clear the skin lesions and other symptoms. We report a three-month-ol:~3 female baby with acrodermatitis enteropathica showing a normal serum zinc level in whom diapnosis was confirmed by typical skin lesions, clinical symptoms and response to oral zinc therapy. (Kor J Dermatol 1996;34(5): 984 987)

팥 포장에서 나비목 해충의 발생과 피해 양상

정진교,서보윤,조점래,권윤희,김길하,Jung, Jin-Kyo,Seo, Bo-Yoon,Cho, Jum-Rae,Kwon, Yun-Hee,Kim, Gil-Ha 한국응용곤충학회 2009 한국응용곤충학회지 Vol.48 No.1

팥포장에서 꽃과 꼬투리, 줄기에 피해를 입히는 나비목 곤충들로 콩명나방(명나방과), 팥나방(잎말이나방과), Ostrinia spp. (명나방과) 3종이 주 해충으로 발견되었는데, 포장 안의 거의 모든 식물체가 세 종 중 적어도 한 종 이상에 의해 가해를 받은 흔적이 있었으며, 꽃과 꼬투리의 $15{\sim}60%$ 정도가 피해를 받았다. 또 개화되지 않은 화서가 생식생장기 동안 계속 출현하는 현상이 나타났다. 미개화 화서의 지속적 출현은 꽃 피해에 의한 보상작용에 의한 것으로 추정되었다. 전체 관찰기간을 통해 콩명나방 유충의 평균밀도가 가장 높았는데, 시기적으로는 팥 생식생장기 중기까지 콩명나방이 우점하였으나 후기에는 Ostrinia spp.가 우점하였다. 콩명나방 유충은 1령부터 5령까지 모든 영기가 관찰되었고, 팥나방은 3령기 이후의 유충 영기들이 관찰되었다. 두 해충 모두 개화기에는 꽃과 줄기에서 주로 관찰되었고 개화기 이후에는 꼬투리에서 더 많이 관찰되었다. Ostrinia spp. 유충은 3령기 이후 영기들이 개화기가 지난 다음부터 관찰되었는데 꼬투리와 줄기에서 발견되었다. Three lepidopteran insect pests of the legume pod borer, Maruca vitrata (Lepidoptera: Pyralidae), the soybean pod worm, Matsumuraeses phaseoli (Lepidoptera: Tortricidae) and an Ostrinia spp. (Lepidoptera: Pyralidae) attacking adzuki bean, Vigna angularis, were confirmed as the major insect pests during the reproductive developmental stage of adzuki bean, and M. vitrata existed dominantly. Almost all plants in the adzuki bean field were injured by at least one of the three species, and $15{\sim}60%$ of reproductive organs were injured. Unbloomed inflorescence occurred continuously through the reproductive stage of adzuki bean. While the flower was many at the early stage and its number soon decreased, the pod was few at the early stage, but its number increased soon and maintained at a constant level. The results suggested that the adzuki bean injured by insect pests compensate the flower loss by developing new inflorescence, but the compensation do not cause the development of new pods. While M. vitrata and M. phaseoli were observed in flowers, pods and stem mainly during the first half of reproductive stage of adzuki bean, Ostrinia spp. was observed only in pods and stem during the second half. In addition, while all instars of larvae of M. vitrata were observed, larvae between the third and fifth instars for M. pahseoli and Ostrinia spp. were observed.

정보관련 예산분석을 통한 전자정부 발전과정

조덕호(Cho Deok Ho),권윤희(Kwon Yoon Hee) 한국도시행정학회 2005 도시 행정 학보 Vol.18 No.2

This study elaborates a new development process of electronic government which especially focuses on the changing process of budget items and their monetary amounts. A large amount of budgets invested on the building of digital database for the internal organizations in the initial stage. The second stage focused on the network building among the governmental organizations. The third stage began to provide the governmental organization with the information on the public administration online. The governmental services for the citizens has begun in the final stage. This paper notes what kind of budget items and how much budget amounts has been invested to build the electronic government in each development stage. And it suggests some policy implications on the budget systems and amounts of information budgets for promoting the development of electronic and ubiquitous government which is the future type of government development.

원발성 폐암과 동반된 Reiter 증후군

하석준 ( Seog Jun Ha ),권윤희 ( Yoon Hee Kwon ),김태윤 ( Tae Yoon Kim ),김정원 ( Chung Won Kim ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.3

Reiters syndrome is an unusual disease characterized a triad of nongonococcal urethritis, conjunctivitis, and arthritis in association with the mircoutaneous lesions of keratoderma blenorrhagica and balarintis circinata. We present herein a case of Reiters syndome combined yiti lung cancer. A 39-year-old man has experienced naigrating polyarthralgia and high fever ilitermittently for about 20 years, Hyperkeratotic erythemnous patches and plaques, which dyeliped about 1 year ago, have aggravated and expanded to the whole body. Histopathologic sections from the plaque on the right forc ari showed characteristic findings including thickened parakeratotic horny layer and spongiform micropustules of Kogoji He was associated with HLA-B27. On the chest X-ray, a thumbtip size mass was incidently found. Chest CT and bone scan findings supported lung cancer and multiele metastases. (Kor J Dermatol 1995;33(3): 580-584)