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만성 B형 간염에서의 페그인터페론 치료 시 망막병증의 임상양상
권용대,임지원,Yong Dae Kwon,Ji Won Lim 대한안과학회 2011 대한안과학회지 Vol.52 No.1
Purpose: To evaluate the clinical features of retinopathy in chronic hepatitis B patients treated with peginterferon. Methods: Chronic hepatitis B patients treated with peginterferon were evaluated during regular routine ophthalmic examinations including fundus examination before and during the 1-year follow-up after treatment. A total of 88 patients were included in the study. Results: Retinopathy developed in 11 (12.5 %) out of 88 patients at a mean of 7 weeks after initiation of treatment. Peginterferon treatment was continued in all patients and retinal abnormalities including cotton wool spot, retinal hemorrhage and microaneurysm resolved without visual impairment. The incidence of hypertension between the retinopathy group and the group without retinopathy was significantly different (P = 0.020). Conclusions: The incidence of retinopathy with peginterferon in chronic hepatitis B patients was low and the prognosis was benign. Thus, routine screening for peginterferon retinopathy is not necessary. J Korean Ophthalmol Soc 2011;52(1):41-45
Bisphosphonate, 구강악안면외과 영역의 새로운 위험 요소인가?
권용대,윤병욱,Kwon, Yong-Dae,Yoon, Byung-Wook,Walter, Christian 대한악안면성형재건외과학회 2007 Maxillofacial Plastic Reconstructive Surgery Vol.29 No.5
Since the first description of bisphosphonate related osteonecrosis of the jaw (BRONJ) in 2002, the number of report on the disease has rapidly been increasing. Now, BRONJ is considered as a new entity, which is emerging problem in oral and maxillofacial surgery. Bisphosphonates (BPs) can be categorized into 2 groups: nitrogen-containing and non-nitrogen containing, and nitrogen-containing BPs are considered to have more efficacy and toxicity possibly. It is unusual for osteonecrosis to occur in the maxilla but BRONJ is found in both the mandible and the maxilla, which is one of the special features of BRONJ compared with common infectious osteomyelitis of the jaws. Intravenous BPs are usually more likely to cause BRONJ than oral BPs which are frequently prescribed for osteoporosis and osteopenia. Nonetheless, the use of intravenous BPs cannot be prevented because of systemic condition of the patients. Although it is rare that oral BPs cause BRONJ in osteoporosis/osteopenia patients, we should be aware of BRONJ since the population of the patients is exceedingly increasing with the prolonging of life expectancy. So, we'd like to enlighten upon the problems and solutions of BRONJ.
권용대,이백수,주성숙,Kwon, Yong-Dae,Lee, Baek-Soo,Jue, Sung-Sook 대한악안면성형재건외과학회 1999 Maxillofacial Plastic Reconstructive Surgery Vol.21 No.3
In oral and maxillofacial surgery, there are many cases requiring the graft of epidermal tissues such as maxillectomy, and vestibuloplasty. There have been so many challenges for the culture of the epidermal tissue. Observing the ultrastructure of the cultured human oral kertinocytes, we could compare this findings with that of in vivo ones. With that, we could find the differencies and similarities between cultured cells and in vivo ones, and evaluate the clinical applications of cultured tissue. Human gingiva was obtained and the specimen was explanted on 24-well plate. Two types of culture media were used in this culture system. One was for the growth of the keratinocytes (Media I), and the other was for the stratification (Media II). Media I had special ingredients for the epidermal growth. Those were 0.5% dimethyl sulfoxide (DMSO), 30ng/ml of epidermal growth factor (EGF), 30ng/ml of cholera toxin, and $5{\mu}g/ml$ of transferrin. We cultured the oral keratinocytes for 3 weeks, and at that time the cultured keratinocytes were processed to prepare the specimen for the TEM study. The results were as follows.; 1. In the phase contrast micrograph, epidermal outgrowth firstly appeared on the 3rd day after explantation, and the growing keratinocytes were activley mitotic, and had polygonal shape and increased N/C ratio. 2. In the phase contrast micrograph, the outer most cells exhibited areas where broad cytoplasmic processes extended out onto the culture subtratum(fan-like appaearance). 3. In the TEM micrographs, the cultured keratinocytes showed stratification. The cells were in elongated form, and there were no morphologic differencies among the layers usually found in the in vivo gingiva. 4. Most of cellular organelles underwent lysis, and keratohyaline granules were seen. Tonofibrils were dispersed in the cytoplasm. 5. The cells were interconnected by desmosomes, and their frequency of distribution was considered to be lower than that of in vivo keratinocytes. 6. We could conclude the cultured oral keratinocytes exhibited signs of terminal differentiation.
권용대,임지원,Yong Dae Kwon,Ji Won Lim 대한안과학회 2010 대한안과학회지 Vol.51 No.8
Purpose: To report a case of lacrimal gland stone initiated by an eyelash. Case summary: A 31-year-old woman presented with foreign body sensation, pain, and conjunctival injection in the lateral palpebral conjunctiva of her right eye over 6 months in duration. The physical examination revealed a small, firm nodule at the lateral canthal area. The excisional biopsy was performed, and the mass was a concretion that contained an eyelash in the center. During one-year follow-up, the patient showed no signs of recurrence or complication after excision. Conclusions: Although rare in occurence, eyelashes may be the initial nidus for lacrimal gland stone formation. J Korean Ophthalmol Soc 2010;51(8):1139-1141
권용대 ( Kwon Yong Dae ),홍종숙 ( Hong Jong Sug ) 한국농촌계획학회 2003 농촌계획 Vol.9 No.3
This paper aimed at identifying rural amenities valuable in terms of marketed value and economic analysis of green tourism so as to develop policy instruments for new rural communities. We conducted the case study on Jik-Dong rural community in Taejeon city estimated income effects of green tourism and internal rate of return of investment for rural amenity facilities. The research results are as followings; ① green tourism participant will spend the worthe of 50,392 won per person, ② earnings from green tourism amounts to about 2,471 thousand won per household, ③ internal rate of return of green tourism investment is estimated as 7%. The strategies for green tourism is suggested as follows; ① rural amenities should be well maintained for green tourism infrastructure ② measures to internalize the value of rural amenities should be developed for market oriented green tourism ③ effective program for inducing visitors with purchasing power should be designed.
권용대(Yong-Dae Kwon),이현우(Hyun-Woo Lee) 대한치과의사협회 2013 대한치과의사협회지 Vol.51 No.6
Among the occlusal discrepancies, maxillary transverse deficiency is quite common in several reasons. The reasons are comprised of maxillary hypoplasia, thumb sucking habits, non-syndromic palatal synostosis and syndromal patients including cleft patients. Orthodontic treatment is used routinely to correct a deficiency in young patients while it has limitations for a skeletally mature patient. Surgical treatments help provide effective maxillary expansion to correct a deficiency in adults. Surgical methods can be categorized to segmental Le Fort I osteotomy and surgically assisted rapid maxillary expansion(SARME). Both methods seem successful but each method would have its own indication. We give a review on transverse maxillary deficiency and two surgical methods.
도시 농산업의 지역산업 연관효과 분석 -대전 광역시의 사례를 중심으로-
권용대 ( Yong Dae Kwon ),임효빈 ( Hyo Bin Lym ) 한국농업경제학회 2013 農業經濟硏究 Vol.54 No.4
This study is performed to define the concept of industrializing urban agriculture which may promote its forward and backward effects on urban economy and to analyze the interindustrial re-lationship with other industries based on the regional input-output accounts of Daejeon city. This paper addresses the description of inter-sectoral linkages through classification with re-lated sectors within the scope of urban agricultural industry. Interindustry analysis method is used to estimate the extent to which sectors of urban agricultural industry can stimulate the growth of urban economy based on the production inducernent coefficient matrix of 20 sectors amalgamated from 78 industrial sectors. The multiplier effect of changes in demand for sectors of urban agricultural industry was esti-mated at 2.5765, greater impact on the urban economy on average. It is emphasized that policy should support clustering urban agriculture and related industries for sustainable growth of the urban economy.