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- 저자 : 구준(Joon Gu) (검색결과 3 건)
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한국의 일 요양 시설에 거주하는 한센병 환자들에서의 치매 유병률
이철순(Cheol Soon Lee),강효승(Hyo Seung Kang),구준(Joon Gu),박철수(Chul Soo Park),손진욱(Jin Wook Shon),김봉조(Bong Jo Kim) 대한노인정신의학회 2007 노인정신의학 Vol.11 No.2
Objectives : To identify prevalence of dementia and it's subtypes in patients with Hansen's disease in a sanatorium of Korea. Methods : The study employs a two-stage design for case identification. One hundred-six patients with Hansen's disease aged 65 and over participated in the study. The Korean Version of the Consortium to Establish a Registry for Alzheimer's disease (CERADK) assessment packet was administered to One hundred-two patients with Hansen's disease. Dementia was defined using the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnostic features of dementia. Results : The prevalence was 15.1% in Hansen's sanatorium. The prevalence of Alzheimer's and vascular dementia were 10.4% and 4.7%. The age-adjusted prevalence rate for dementia was 11.9%. The rate of patients with dementia was 12.73% in males and 17.65% in females. Conclusion : The prevalence of dementia in Hansen's disease sanatorium of Korea appears to be similar with those reported in previous study. Our result suggests that Hansen's disease was unrelated to prevalence of dementia, and also that the dementia is major neuropsychiatric disease in patient with Hansen's disease.
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한국인 집단에서 알코올 의존과 세로토닌 수송체 유전자 다형성의 연관성
이철순(Cheol-Soon Lee),노양덕(Yang-Duck Noh),구준(Joon Gu),박철수(Chul-Soo Park),손진욱(Jin-Wook Shon),한규희(Kyu-Hee Hahn),김봉조(Bong-Jo Kim) 대한생물치료정신의학회 2007 생물치료정신의학 Vol.13 No.2
Objective:Family, twin, and adoption studies have demonstrated that genes play an important role in the development of alcoholism. We investigated the association between alcoholism and the genetic polymorphisms of the serotonin transporter regulatory gene(5-HTTLPR) in Korean population. We also explored the association between the genetic polymorphisms of the 5-HTTLPR and clinical characteristics in patients with alcohol dependence. Methods:The genotype and allele frequencies of the 5-HTTLPR were investigated in 172 control subjects and 162 male hospitalized patients who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition(DSMIV), criteria for alcohol dependence. Several standardized research scales were used for the clinical assessment of alcoholism, including the Alcohol Dependence Scale(ADS), the Beck Depression Inventory, the Beck Anxiety Inventory, and the Obsessive-Compulsive Drinking Scale. Results:We found that the frequency of LL genotype and L allele was higher in patients with alcohol dependence than that of control subjects. Alcoholics with the 5-HTTLPR LS or SS genotypes had a later age of onset (mean age of onset, 29.4 and 32.1 years, respectively) than those with the LL genotype(mean age of onset, 25.9 years;p=.002). Also we found that the polymorphisms of the 5-HTTLPR were associated with the scores of the ADS, but not associated with the scores of the BDI, BAI, and OCDS. Alcoholics with the L allele had an earlier age of onset and higher scores of the BDI than those with the S allele(respectively p=.019, p=.021). The scores of the ADS were higher in patients with the S allele than those with the L allele(p=.002). Conclusion:Our finding suggest that genetic polymorphisms of the 5-HTTLPR may be associated with the development of alcoholism and that the 5-HTTLPR play an important role in the development of the early onset and the severe type of alcoholism.
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한국인 집단에서 알코올 의존과 Tryptophan Hydroxylase A218C 유전자 다형성의 연관성
이철순(Cheol-Soon Lee),박철수(Chul-Soo Park),이환철(Hwan-Chul Lee),구준(Joon Gu),손진욱(Jin-Wook Sohn),한규희(Gyu-Hee Hahn),윤혁진(Hyuck-Jin Yoon),김봉조(Bong-Jo Kim) 대한생물치료정신의학회 2006 생물치료정신의학 Vol.12 No.1
목적 : 알코올 의존은 환경적 요인과 생물학적 요인이 복합되어 발생하는 것으로 널리 알려진 질환으로 최근 가족, 쌍생아 및 양자 연구에서 유전적 요인의 중요성이 시사되고 있다. 본 연구는 알코올 의존의 유전적 요인을 찾기 위해 세로토닌 합성 조절 효소인 tryptophan hydroxylase(TPH) A218C 유전자 다형성 빈도를 정상 대조군과 비교하였으며 알코올 의존 환자에서 TPH A218C의 유전자 다형성과 임상적 변인과의 관련성을 알아보고자 하였다. 방법 : DSM-Ⅳ 진단 기준에 부합되는 알코올 의존 환자 162명과 정상 대조군 182명을 대상으로 TPH 유전자 분석을 시행하였다. 알코올 의존 환자에서 TPH 유전자 다형성과 임상적 변인간의 관련성을 알아보기 위해서 알코올 의존 환자들을 대상으로 알코올 의존 척도, 불안 척도, 우울 척도, 강박적 음주 척도를 조사하였다. 결과 : 알코올 의존 환자군에서 정상 대조군에 비하여 AA 유전자형과 A 대립 유전자의 빈도가 높게 나타났다. 유전자형에 따른 평균 발병 연령을 조사한 결과 AA, AC, CC에서 각각 25.8세, 30.5세, 33.6세로 조사되어 AA 유전자형을 가진 환자군에서 유의하게 낮은 발병 연령을 보였다(p<0.001). 또한 AA 유전자형을 가지는 환자군에서 CC 유전자형을 보인 환자군에 비하여 알코올 의존 척도에서 유의하게 높은 값을 가지는 것으로 나타났다(p=0.001). 결론 : TPH A218C 유전자 다형성이 알코올 의존의 원인적 요인으로 작용할 있을 뿐만 아니라 발병 연령 및 증상 심각도와 관련이 있다. 이러한 결과는 조기 발병하고 심각한 알코올 의존과 같은 알코올 의존 아형 분류의 생물학적 근거가 될 수 있다. Objective : Family, twin, and adoption studies have demonstrated that genes play an important role in the development of alcoholism. In this study, we explored the genetic causes of alcohol dependence by comparing the frequency of the tryptophan hydroxylase(TPH) A218C between patients with alcohol dependence and control subjects in Korean population. We also explored the association between TPH A218C polymorphism and clinical characteristics in patients with alcohol dependence. Method : The genotype and allele frequencies of TPH were investigated in 182 normal control and 162 male hospitalized patients who met Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, (DSM-Ⅳ) criteria for alcohol dependence. We conducted clinical assessments using Alcohol Dependence Scale(ADS), Beck Depression Inventory, Beck Anxiety Inventory, and Obsessive-Compulsive Drinking Scale. Results : The frequency of AA genotype and A allele is higher in patients with alcohol dependence than in normal control. Alcoholics with the TPH CC or AC genotypes had a later age of disease onset(mean age of onset, 33.6 and 30.5 years, respectively) than those with the AA genotype(mean age of onset, 25.8 years ; p<0.001). Also we found the TPH AA genotype has a higher score on the Korean version of the ADS than those with CC genotypes(p=0.001). Conclusion : Our results suggest that TPH polymorphism may be a crucial factor in the development of alcohol dependence and may explain, in part, the biological basis for these typologies.
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