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구본철 ( Bon Cheol Goo ),이주희 ( Ju Hee Lee ),이광훈 ( Kwang Hoon Lee ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.10
Pseudoxanthoma elasticum-Like papillary dermal elastolysis is a disorder of the dermis, characterized by clinical features similar to pseudoxanthoma elasticum and the pathologic features of elastolysis limited to the papillary dermis, such as sun-protected, intrinsically-aged skin. A 64-year old woman presented with a 7 year history of a localized skin lesion on the back of her neck. Physical examination revealed skin to yellow colored, non-follicular grouped uniform papules, sized 5~8㎜, and coalescent plaques localized below the hair line. Histopathologic and immunohistochemical findings of decrease and elastolysis of the elastic fibers in the papillary dermis confirmed the diagnosis. In this article, we report a case of pseudoxanthoma elasticum-like papillary dermal elastolysis which presented with typical clinical and pathologic features. (Korean J Dermatol 2006;44(10):1228~1230)
경화성 섬유종과 유사한 조직 소견을 보인 피부 섬유종 2예
최윤진 ( Yoon Jin Choi ),구본철 ( Bon Cheol Goo ),정진영 ( Jin Young Jung ),정혜진 ( Hye Jin Chung ),정기양 ( Kee Yang Chung ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.6
Sclerotic fibroma is often regarded as a unique proliferating lesion, but some authors regard it as an end stage of other neoplasms, especially dermatofibroma. We report two cases of dermatofibroma with sclerotic fibroma-like change. The skin biopsy specimens from different patients showed a common finding of dermatofibroma, while some portions of the tumor were replaced by thick, hyalinized, eosinophilic collagen bundles and empty clefts with low cellularity, which was histologically similar to sclerotic fibroma. According to these findings, dermatofibroma with sclerotic fibroma-like change can be evidence of the possible pathogenesis of sclerotic fibroma. (Korean J Dermatol 2007;45(6):581∼584)
정진영 ( Jin Young Jung ),구본철 ( Bon Cheol Goo ),한은천 ( Eun Chun Han ),정혜진 ( Hye Jin Chung ),정기양 ( Kee Yang Chung ) 대한피부과학회 2007 大韓皮膚科學會誌 Vol.45 No.8
Neutrophilic eccrine hidradenitis (NEH) is a rare neutrophilic dermatosis which clinically presents with various cutaneous manifestations with or without tenderness and pruritus. NEH has a characteristic histologic pattern, with necrosis of the eccrine glands and local neutrophilic infiltrations. It occurs mostly in patients receiving chemotherapy for acute myeloblastic leukemia or, less frequently, other malignancies. More recently, NEH has been observed in other conditions, such as infections, drugs or even in generally healthy individuals. We report a case of a 29- year-old female with no remarkable medical history who has suffered from a solitary skin-colored indurated macule with tenderness on the left sole for 2 weeks. The skin biopsy showed typical features of neutrophilic eccrine hidradenitis. The patient was successfully treated with oral prednisolone for 2 weeks and an intralesional injection of triamcinolone. (Korean J Dermatol 2007;45(8):867∼869)
모스미세도식수술로 치료한 소낭성 피부 부속기 암종 1예
이규엽 ( Kyu Yeop Lee ),구본철 ( Bon Cheol Goo ),장재용 ( Jae Yong Jang ),정기양 ( Kee Yang Chung ) 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.12
Microcystic adnexal carcinoma (MAC) is an uncommon skin appendage neoplasm with both follicular and sweat duct differentiation. It usually extends microscopically far beyond assessed clinical margins and spreads locally in the dermal, subcutaneous fat, muscle, and perineural tissue planes. Although its metastasis is very rare, local recurrence rate after standard excision is 40~59%. Recently, Mohs micrographic surgery (MMS) was introduced for the treatment of MAC and a more favorable cure rate has been reported. We report a case of MAC, which was treated by MMS, which concurred with thymoma and thyroid papillary carcinoma in a 50-year-old woman. (Korean J Dermatol 2006;44(12):1444~1447)
권연숙 ( Yeon Sook Kwon ),구본철 ( Bon Cheol Goo ),오상호 ( Sang Ho Oh ),이광훈 ( Kwang Hoon Lee ),이주희 ( Ju Hee Lee ) 대한피부과학회 2008 大韓皮膚科學會誌 Vol.46 No.6
Background: Molluscum contagiosum is a common cutaneous viral infection of the skin. Although molluscum contagiosum generally affects young children, the incidence in adults is rising. Objective: The purpose of our investigation was to describe the clinical characteristics of 28 adults with biopsy- proven molluscum contagiosum. Methods: We reviewed the medical records and clinical photographs of 28 patients who were diagnosed with molluscum contagiosum from June 2000 to May 2007. Personal and clinical information such as onset, age, gender distribution, clinical manifestations, associated diseases, pathologic characteristics and treatment modalities were investigated. Results: Of the 28 patients, 19 (67.9%) were men and 9 (32.1%) were women. The average age of onset in men and women were 39.4 and 46.4 years, respectively and the overall average age of onset was 41.7 years. The most common clinical finding was a typical umblicated papule in 10 (35.7%) of the 28 cases. The atypical presentations including giant molluscum, chickenpox-like lesions, prurigo-like lesions and verruca-like lesions were also seen. The most common affected site was the genital area, followed by the head and neck, extremities and trunk. Except for the 21 asymptomatic patients, 7 patients complained of pruritus. Seropositive ELISA assays for HIV was found in 1 patient. Five patients were under immunosuppressive conditions such as HIV infection, sarcoidosis, taking immunosuppressant drugs after liver transplantation, chemotherapy for breast cancer and chemotherapy for gastric cancer. Molluscum bodies were confirmed in all patients through histologic findings. Molluscum extraction was mainly used as a treatment of molluscum contagiosum. Conclusion: In Korean literature, this is the first clinical study of molluscum contagiosum occurring in adults. Molluscum contagiosum in adults shows atypical clinical features, so it can be misdiagnosed as other diseases. We suggest that dermatologists should perceive clinical findings of molluscum contagiosum in adults and perform proper investigation and management. (Korean J Dermatol 2008;46(6):749∼756)