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모스미세도식수술로 치료한 소낭성 피부 부속기 암종 1예
이규엽 ( Kyu Yeop Lee ),구본철 ( Bon Cheol Goo ),장재용 ( Jae Yong Jang ),정기양 ( Kee Yang Chung ) 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.12
Microcystic adnexal carcinoma (MAC) is an uncommon skin appendage neoplasm with both follicular and sweat duct differentiation. It usually extends microscopically far beyond assessed clinical margins and spreads locally in the dermal, subcutaneous fat, muscle, and perineural tissue planes. Although its metastasis is very rare, local recurrence rate after standard excision is 40~59%. Recently, Mohs micrographic surgery (MMS) was introduced for the treatment of MAC and a more favorable cure rate has been reported. We report a case of MAC, which was treated by MMS, which concurred with thymoma and thyroid papillary carcinoma in a 50-year-old woman. (Korean J Dermatol 2006;44(12):1444~1447)
골수이형성 증후군 환자에서 발생한 조직구양 Sweet 증후군 1예
이규엽 ( Kyu Yeop Lee ),권연숙 ( Yeon Sook Kwon ),김도영 ( Do Young Kim ),김세훈 ( Se Hoon Kim ),이광길 ( Kwang Gil Lee ),방동식 ( Dong Sik Bang ) 대한피부과학회 2007 大韓皮膚科學會誌 Vol.45 No.7
Sweet`s syndrome is an acute febrile neutrophilic dermatosis that occurs with malignant disease, mainly myeloid hemopathies, in about 20% of cases. When associated with myelodysplasia, clinical and histologic features of Sweet`s syndrome can be atypical; however its significance is still debated. We encountered a case of Sweet`s syndrome associated with myelodysplastic syndrome in a 63-year-old woman. The clinical presentation strongly suggested Sweet`s syndrome but, histopathologic examination showed dense histiocytic infiltration with prominent upper dermal edema and little neutrophil infiltration. In the evaluation for atypical histopathology and laboratory abnormalities, she was diagnosed with myleodysplastic syndrome by peripheral blood smear and bone marrow biopsy. Histiocytoid Sweet`s syndrome is a currently accepted concept and probably has a close relation with underlying myeloid hemopathies. (Korean J Dermatol 2007;45(7):754∼757)
이규엽 ( Kyu Yeop Lee ),류동진 ( Dong Jin Ryu ),정혜진 ( Hye Jin Chung ),방동식 ( Dong Sik Bang ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.4
Aplasia cutis congenita is a rare congenital skin defect that presents with sharply outlined ulcerations. The most common site of this disease is the scalp, yet when other areas of the body are involved, there is higher incidence of concomitant congenital diseases or malformations. Bart`s syndrome is a rare inherited condition with congenital skin defects that are associated with epidermolysis bullosa. An infant presented with congenital skin defects on the leg, and the infant had recurrent bullous skin lesions on the both hands, feet, wrists and ankles. The skin defect caused only small scar formation and no handicap regarding function and appearance, yet continuously new bullous lesion developed and healed on the both distal extremities. He was diagnosed as suffering with epidermolysis bullosa with the histological findings of epidermal cleavage and negative direct immunofluorescence findings. Herein, we report on a case of Bart`s syndrome that displayed aplasia cutis congenita over the lower extremities and skin blistering. (Korean J Dermatol 2009;47(4):463~467)
이규엽 ( Kyu Yeop Lee ),신정우 ( Jung U Shin ),최윤진 ( Yoon Jin Choi ),정혜진 ( Hye Jin Chung ),정기양 ( Kee Yang Chung ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.3
Very rare and unique tumors of infants, fibrous hamartomas were first described by Reye in 1956 as a subdermal fibromatous tumor of infancy. The tumors can occur at birth and are usually diagnosed within the first 2 years of life. The oldest patient reported in the literature was an 11-year-old child. The common sites of involvement are the axillae, upper arms, and upper trunk. Although the lesion is not distinctive clinically, it has a characteristic microscopic appearance of fibrous tissue forming trabeculae, small, round cells that represent primitive mesenchyme, and mature adipose tissue. Herein, we report a case of fibrous hamartoma of infancy in a 26-year-old man, on the uncommon site of a lower extremity. (Korean J Dermatol 2008;46(3):359∼361)
침술 요법 부위에 발생한 Mycobacterium fortuitum 감염증 1예
최윤진 ( Yoon Jin Choi ),이희정 ( Hee Jung Lee ),이규엽 ( Kyu Yeop Lee ),류동진 ( Dong Jin Ryu ),이민걸 ( Min Geol Lee ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.6
Mycobacterial infections that are transmitted by acupuncture are an emerging problem. M. fortuitum is one of the rapid-growing atypical mycobacteria and this infection usually follows a puncture wound or a surgical procedure. We report here on a case of M. fortuitum infection following an acupuncture procedure. A 37-year-old woman presented with indurations and ulcerations of both popliteal fossae after undergoing acupuncture. The skin biopsy specimen showed suppurative inflammation with a lymphocytic infiltration, and the Ziehl-Neelsen stain for AFB was negative. Bacterial culture of the tissue fluid was negative. The culture of the tissue specimen and polymerase chain reaction revealed M. fortuitum. The infection responded to 10 weeks of treatment with isoniazid, rifampin and ethambutol, and four months of treatment with rifampin. Despite of the increasing popularity of acupuncture, the importance of infection control has not been adequately emphasized in oriental medicine. Education for proper infection control, including aseptic practice, is necessary for oriental medical doctors and practitioners. (Korean J Dermatol 2009; 47(6):755∼758)