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원발쓸개관경화증에서 발생한 갑상샘유두암과 혼합결합조직병 1예
구동완 ( Dong-wan Koo ),이승근 ( Seung-geun Lee ),박은경 ( Eun-kyoung Park ),박지혜 ( Ji-heh Park ),이규민 ( Kyu-min Lee ) 대한내과학회 2017 대한내과학회지 Vol.92 No.1
A 40-year-old female previously diagnosed with primary biliary cirrhosis was referred to the hospital complaining of muscle weakness, arthralgia, Raynaud`s phenomenon, and thick skin. After work-up, she was diagnosed with both mixed connective tissue disease (MCTD) and papillary thyroid cancer (PTC), based on the Alarcon-Segovia criteria and pathological examination, respectively. High-dose glucocorticoid and azathioprine were introduced to treat active myositis of MCTD, and total thyroidectomy was performed to treat PTC. This report highlights the possible association between MCTD and thyroid cancer, and suggests that MCTD is associated with PTC, similar to other autoimmune diseases including Sjogren`s syndrome, systemic sclerosis, and systemic lupus erythematosus. (Korean J Med 2017;92:103-107)
새로운 Sulfonylurea 유도체의 합성과 제초활성
전동주(Dong Ju Jeon),구동완(Dong wan Koo),고영관(Young Kwan Ko),홍경식(Kyung-Sik Hong),김대황(Dae-Whang Kim) 한국농약과학회 2001 농약과학회지 Vol.5 No.2
New series of sulfonylureas containing substituted thiophene with 2-chloromethyl-l,3-dioxolane group were prepared, and their herbicidal effects were tested(in vivo) in the upland conditions and in the paddy submerged conditions. The sulfonylureas in which 4,6-dimethoxy- or 4-methyl-6-methoxy group in pyrimidine or triazine ring showed good herbicidal effects at a rate of 0.1 ㎏/㏊. However, they showed weaker herbicidal effects than that of sulfonylureas containing substituted thiophene with 2-fluoromethyl-l,3-dioxolane group in general.
신규 잔디 제초제 메티오졸린(methiozolin) 개발
구석진(Suk-Jin Koo),황기환(Ki-Hwan Hwang),전만석(Man-Seok Jeon),김성헌(Sung-Hun Kim),임종수(Jongsoo Lim),이동국(Dong-Guk Lee),정근회(Kun-Hoe Chung),고영관(Young-Kwan Ko),류재욱(Jae-Wook Ryu),구동완(Dong-Wan Koo),우재춘(Jae-Chun Woo) 韓國雜草學會 2010 Weed&Turfgrass Science Vol.30 No.4
Methiozolin (5-(2,6-difluoro-benzyloxymethyl)-5-methyl-3-(3-methyl- thiophen-2-yl)- 4,5-dihydro-isoxazole) is a new turf herbicide in isoxazoline chemistry. The herbicide controls grass weeds and has a high safety to various cool and warm season turfgrasses. This paper describes basic chemical, biological, and regulatory information of methiozolin.