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아토피피부염 환자에서 Interleukin-10 , Tumor Necrosis Factor - beta ( TNF-β ) 유전자의 다형성에 관한 연구
고보경(Bo Kyung Koh),김정수(Jung Soo Kim),한훈(Hoon Han),이권행(Kweon Haeng Lee),김진우(Jin Wou Kim) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.5
N/A Background : Atopie dermatitis (AD) is a common inflammatory skin disease. Atopic dermatitis is associated with increased IL-4, IL-5, IL-10 and IL-13 but decreased 1NF-γand TNF production. IL-10 production has peen implicated in autoimmunity because of its effect on B-cell proliferation and antibody production. The study of IL-10 gene polymorphism is of interest because of the pivotal role of IL-10 In the regulation of inflammatory and immune responses. TNF-β significantly upregulates INF-γ but downregulates IL-5, IL-13 and IgE, which suggests a potential role of TNF-β in the pathogenesis of atopie dermatitis. Objective : We have investigated polymorphism of IL-10 promoter gene and TNF-α gene. Methods : Seventy one patients with atopie dermatitis and one hundred and sixty six normal subjects participated in this study with analysis of polymorphism of IL-10 promoter (-1082), (-819) gene and seventy one partions dermatitis and hundred and forty one normal subject participated in the analysis of polymorphism of TNF-β gene. The patients in this study were recently diagnosed with atopie dermatitis. Results : The frequency of IL-10 promoter (-1082) genotypes (A/A, A/G, G/G), genes (A, G), IL-10 promoter (-819) genotypes (T/T, T/C, C/C) and genes (T, C) did not show any significant difference between atopee dermatitis patients and normal controls. There was no sigmificant defference in the frequency of TNFB genotypes (TNFB^☆1/ /TNFB^☆1, TNFB^☆1/TNFB^☆2, TNFB^☆2/TNFB^☆2) and genes (TNFB^☆1, TNFB^☆2) it patients of atopie dermatitis and normal controls. Conclusion : The result of this study suggest that the other regions of the IL-10 promoter gene and TNFB gene should be investigated for polymorphism of atopie dermatitis. And the difference of IL-10 promoter TNFB gene polymorphism between caucasian and Korean needs to he evaluated.
이현정(Hyun Jeong Lee),고보경(Bo Kyung Koh),김진우(Jin Wou Kim) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.4
Neurofibroma occurs as a sporadic tumor or hereditary lesions associated with neurofibromatosis. Histologically, cutaneous extraneural type is the most common form. Occasionally plexiform type is observed, but deep circumscribed intraneural type is rarely found in the skin. We report a case of well-encapsulated intraneural neurofibroma on the left abdomen of a 23-year- old woman showing various histologic features of neurofibroma. The tumor was encapsulated with perineurium which was continuous with remnant nerve of origin. (Korean J Dermatol 2000;38(4):530~532)
Postmenopausal frontal fibrosing alopecia 1 예
김진우,하석준,이현정,김형옥,고보경 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.7
Postmenopausal frontal fibrosing alopecia is a recently described, rare scarring alopecia. The disease is characterized by progressive frontal recession in postmenopausal women with clinical features of a fibrosing alopecia. The histologic findings are indistinguishable from those seen in lichen planopilaris. Postmenopausal frontal fibrosing alopecia is especially rare in Asian women. We describe a typical case of postmenopausal frontal fibrosing alopecia in a Korean woman with clinical and histologic features.
이민숙,이경호,김진우,고보경 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.2
Linear lichen planus, a variant of lichen planus, accounts for 0.24-0.62% of all patients with lichen planus. Clinically, it consists of itchy linearly distributed violaceous papules, usually lasts for more than I year and the mucous membranes may also be affected. This disorder shows the same histologic findings of lichen planus, which is characterized by a band like dermal inflammatory cell infiltration with hyperkeratosis, focal hypergranulosis, acanthosis, excytosis and the presence of Civatte body. We report a 66-year-old man showing typical clinical ad histological features of linear lichen planus with pruritus. (Korean J Dermatol 2004;42(2):199~201)
조백기,이종육,박철종,고보경 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.4
Generalized perforating granuloma annulare is a rare variety of granuloma annulare presenting a distinct clinical pattern. We, herein, report a case of generalized perforating granuloma annulare with diabetes mellitus, which developed on a 73 year-old-female who had pruritic generalized small papular lesions with central umbilication, especially on the back and lower extremities for 1 month. Histopathologic examination showed an epidermal perforation and transepidermal elimination of necrobiotic material. The epidermal perforation was communicated with areas of necrobiotic collagen surrounded by palisading granuloma in the dermis.
김연정,이경호,김진우,고보경 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.3
We report a case of solitary vellus hair cyst on the forehead in a 48 year-old, female patient. She had an asymptomatic, solitary, bluish, 0.3×0.3㎝ sized papule on the forehead for 1 year. There was no family history of similar lesions. A punch biopsy specimen taken from the papule revealed a cystic structure in the dermis lined by squamous cell epithelium which contained laminated keratinous material and vellus hairs. Based on this histologic finding, we diagnosed this case as solitary vellus hair cyst occurring on the unusual site of the forehead. (Korean J Dermatol 2004;42(3):347~349)
최문정,이상욱,김진우,고보경 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.3
A corn is a circumscribed hyperkeratotic lesion with a central conical core of keratin that causes pain and inflammation. Corns result from hyperkeratosis, which is causes by an increase in keratinocyte activity associated with stimulation of the epidermis from chronic pressure or friction on the skin. The conical core in a corn, which is a thickening of the stratum corneum, is a protective response to the mechanical trauma. We experienced a man who developed a corn on the buttock, which is and unusual site.