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Methotrexate 의 D 및 L 체가 사람 임파구 염색체에 미치는 영향에 대하여
김정중(Jeongjoong Kim),고건일(Geonil Ko),정연태(Yoentae Jeong),김재백(Jaebaek Kim) 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.4
Sister chromatid exchanges (SCEs) induced by D-methotrexate (MTX) was investigated and compared to L-methotrexate at same doses in cultured PHA activated human lymphocytes. The results is as follows; the frequencies were found to be 11.00±0.31, 13.99±0.27, 16.97±0.32, 21.00±0.43, and 7.85±0.26 in treated with 10^(-6), 10^(-6) Mol D-MTX. L-MTX and the control, respectively. L-MTX was found to be more potent for inducing SCE than D-MTX. The regions generally vulnerable to D -and L-MTX were 1p32 and 1p23 in chromosome 1, 2q21 and 2q31 in chromosome 2, 3q21 and 3p21 in chromosome 3. SCE induced by both D-and L-MTX occurred mostly in the G-light band regions.
HPMCAS 의 pH 의존 용해성에 대한 기전과 약제학적 평가
서순철(Soonchul Seo),고건일(Geonil Ko),김재백(Jaebaek Kim) 한국약제학회 1986 Journal of Pharmaceutical Investigation Vol.16 No.4
For study of pharmaceutical properties of HPMCAS, film made by HPMCAS were tested for dissolution rate, for resistance in acidic solution and for stability under accelerated temperature and humidity condition. And also film coating preparations(VB₂ tablet, VB₂ granule, Cefalexin granule) were tested in vitro and in vivo test. The result is as follows. 1) pH-dependent solubility of HPMCAS was related with their dissociation constant. 2) HPMCAS is stable in accelerated condition and resist in acidic solution. 3) Sustained release part of preparation made by HPMCAS coating are as same pattern as organic solvent system of Eudragit L-90.
고건일 圓光大學校 藥品硏究所 1986 藥品硏究所報 Vol.1 No.1
Effects of Bistcain are investigated in acute gastritis and gastric ulcer of mouse, rat and rabbit. In this result, Bistcain showed the decrease of mucouse inflammation and fatality in mice, rats and rabbits.