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심재성 낭종성 직장염의 수술적 치료 1례 : Surgical treatment of proctitis cystica profunda
강헌대,배기범,신진용,홍관희 白中央醫療院 2004 仁濟醫學 Vol.25 No.1
Proctitis cystica profunda (PCP) is a rare benign disease of the colon and rectum in which mature glandular epithelium extends into the tissue beneath the muscularis mucosa. It is important that the lesion be differentiated from a mucinous adenocarcinoma. Patients with this condition usually present with a palpable rectal mass, tenesmus and bloody mucoid diarrhea. The diagnosis is suspected usually on the basis of clinical symptoms, endoscopic appearance and histology. Definite diagnosis is made histopathology. The histologic findings are usually typical and it may be possible to differentiate this disorder from malignancy on tissue biopsy. In cases of the difficulty of histologic confirmation, more extirpative excision may be considerd. We report one case of proctitis cystica profunda managed surgically.
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갑상선 유두상 암종에서 종양혈관형성 및 혈관내피성장인자 발현의 예후인자적 의의
강헌대(Hun Dae Kang),김성배(Seong Bae Kim),김태현(Tae Hyun Kim),오상훈(Sang Hoon Oh),윤혜경(Hye Kyong Yoon),김상효(Sang Hyo Kim) 대한두경부종양학회 2004 대한두경부 종양학회지 Vol.20 No.2
Objectives: The purpose of this study was to evaluate for prognostic significance of VEGF expression and tumor angiogenesis in papillary carcinomas of the thyroid. Materials and Methods: The materials were 79 cases of papillary thyroid carcinomas, and age, sex, tumor size, multiplicity of tumor, capsular invasion, lymph node metastasis, recurrence, TNM stage, DeGroot stage and AMES scale were evaluated. An immunohistochemical stains for CD 34 to estimate microvessel density (MVD), and VEGF were done. MVD was defined as an average count of vessels per ×400 power field in the most vascularized area. VEGF expression was interpreted as 1+ and 2+ according to staining intensity and percentages of positive cells. Results: Mean score of MVD was 39.7±16.9. MVD were significantly higher in cases with capsular invasion (p=0.0001), lymph node metastasis (p=0.0001), TNM stage III (p=0.0022), DeGroot stage III (p=0.0163) and high risk group by AMES scale (p=0.0001). VEGF 2+ expression rate was significantly increased in cases with capsular invasion and lymph node metastasis (p=0.0006, p=0.0013), and in cases with TNM stage III, DeGroot stage III and high risk group by AMES scale (p=0.0236, p=0.0003, p=0.0293). In VEGF 2 + expression group, MVD was significantly higher than in VEGF 1 + group (p=0.0008), and MVD showed positive relation to VEGF 2 + expression (r=0.4616). Conclusion: VEGF expression and high MVD were significantly correlated to capsular invasion, lymph node metastasis, TNM stage III, DeGroot stage III and high risk group by AMES scale. The expression of VEGF and high MVD could be considered to be one of prognostic factor in papillary thyroid carcinomas.
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신호식,박찬호,이찬우,제호준,강헌대,이상학 대한혈액학회 2007 Blood Research Vol.42 No.1
자가적혈구감작증후군(Gardner-Diamond 증후군)은 동통성타박상증후군 또는 심인성자반증으로 알려져 있으며 정신적인 스트레스 상황이 발생한 후에 갑작스런 동통이 동반된 반상출혈이 발생되는 질환이다. 현재까지 이 질환의 원인은 밝혀지지 않은 상태이며 감정적, 정신적으로 취약한 중년 여성에서 주로 발생한다고 한다. 검사상 기질적인 질환이 없다는 것이 확인된 상태에서 임상양상, 자가적혈구 감작검사 및 신경정신과적 검사를 통해서 진단을 내리게 된다. 저자들은 성인 남성에서 발생한 자가적혈구감작증후군으로 진단된 1예를 경험하였기에 보고하는 바이다.
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