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트리클로로에틸렌이 흰쥐의 태반 기능과 발생에 미치는 영향
강정학 ( Jeong Hak Kang ),이채관 ( Chae Kwan Lee ),문덕환 ( Deog Hwan Moon ),손병철 ( Byung Chul Son ),김대환 ( Dae Hwan Kim ),이창희 ( Chang Hee Lee ),김휘동 ( Hwi Dong Kim ),김정원 ( Jung Won Kim ),김종은 ( Jong Eun Kim ),이채언 한국산업위생학회 2004 한국산업보건학회지 Vol.14 No.3
This study aimed at investigating the toxic effects of trichloroethylene (TCE) on the placental function and reproduction in rat. For these study placental prolactingrowth hormone (PRL-GH) family gene expression, placental trophoblast cell frequency and reproductive data were analyzed. Pregnancy of the Sprague-Dawley rats were checked by the presence of the copulatory plug or sperm in the vaginal smear and defined as the pregnant day (PD) 0. The pregnant rats were divided into the three groups. The control group was intraperitoneally injected with sesame oil. The remaining groups were injected with 100 or 500mg/kg B.W/day of TCE resuspended with sesame oil from PD 7-11 or 16-20. Rats were sacrificed at PD 11 and 20. mRNA levels of PRL-GH family and Pit-1a, b isotype genes were analyzed by Northern blot hybridization and Reverse transcription-polymerase chain reaction. Hormone concentration was analyzed by radioimmunoassay. Frequency of placental trophoblast cells were observed by histochemical study. Reproductive data such as placental and fetal weights pregnancy period, and litter size were surveyed at PD 20 and after birth. Statistical analysis was carried out by the SAS program (version 8.1). mRNA levels of PRL-GH family genes such as placental lactogens and placental prolactin like proteins were reduced by TCE administration. mRNA level of Pit-1a, b isotype genes that induce the expression of PRL-GH family genes were also reduced by TCE administration. Placental lactogen II concentration in the placenta, fetus and maternal blood were decreased by TCE administration. Exposure to a high dose of TCE reduced the frequency of the spongiotrophoblast cell in junction zone. Reproductive data such as placental and fetal weights, litter size were reduced, and pregnancy period was extended in the TCE exposed group than control. These data suggested that TCE disrupts the ordered functions of placenta and these effects lead to the reproductive disorder in rat.
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유철인,이지호,강정학,이헌,이충렬,Yoo, Cheol-In,Lee, Ji-Ho,Kang, Jeong-Hak,Lee, Hun,Lee, Choong-Ryeol 대한예방의학회 1999 Journal of Preventive Medicine and Public Health Vol.32 No.2
Objectives: To ascertain whether some result of hematological examination could be as reference data for health management of welders. Method: The authors conducted the hematological examination of 1,018 welders and 531 control workers of a shipbuilding industry in Ulsan using automatic blood analyzer. Results: The WBC count of welders was lower than that of control on controlling the age and the duration of employment, but changes of other blood cells were not observed. Conclusion: We could use the results of hematological examination such as WBC counts as an indicator for subtle changes of health status of welders.
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김영숙,손혜숙,강정학,이창희,이채언,Kim, Young-Sook,Shon, Hae-Sook,Kang, Jeong-Hak,Lee, Chang-Hee,Lee, Chae-Un 대한예방의학회 1995 Journal of Preventive Medicine and Public Health Vol.28 No.3
Authors purposed to observe activities of occupational health nurses and it's related factors, and to suggest the way that induct better occupational health nurses' activities with questionaire to 87 occupational health nurses who individually work as health manager in the plant. The questionaire included type of plant and number of workers, general characteristics, work conditions, activities, etc. Major findings are as follows. 1. 82.8% of occupational health nurses were third decade. 93.1% graduated junior college or college. And 82.8% were not married. 2. General work conditions: 40.2% were belonged to safety-health section, 98.85% were mere clerks. 60.9% worked less than weekly 44 hours, and an annual salary of 50.6 % was between 10 million and 14 million won. 3. Work condition related to health manager work: there was separated health care room in 94.3%, working period as health manager(occupational health nurse) was less than 5 years in 70.1%, 49.4% had the out-of-health manager work. In 87.4%, occupational physician was appointed, only 6.9% of them were full time, 52.9% of them worked little in the plants. The problems related to workers' health were discussed with industrial nurses in 88.5%. 4. Attitude for their work: 88.5% were thought that their work is important for workers' health care, 57.5% satisfied to work as health manager. In 51.7%, motive to being industrial nurse were the appropriate aptitude. 5. Activities: General medical care in 100% were carried out, in 97.7% works related to general health examination, in 100% works related to special health examination were carried. But works related to use of protective apparatus were carried out in 20.8%. 6. Factors related to level of activities: In cases who solved the health related problems by themselves, the level of activites was significantly higher than in others. In cases there were full time occupational physician, the level of activities was significantly lower. 7. Occupational health nurse's needs: 100% wanted regular education, 89.7% wanted the qualifying examination. As the results, author suggests that the right of self-control is given to occupational health nurses and the work of occupational physician is clearly defined for the induction of the better activities of occupational health nurses.
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이충렬,류철인,이지호,강정학,강성규,양정선,신용철 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.3
Six cases of nasal septum perforation were found among welders during periodic physical checkup in 1997. Considering the size, shape and margin, the perforations were assumed to have been occurred several years before of which the diameter were 8∼15mm. To investigate the cause of perforation, we reviewed the past history of preemployment, the results of annual working environment survey and the material safety data sheets of welding rods and steels with which they have dealt, and analyzed the concentration of several metals of welding fume and the concentration of blood and urinary chromium. In the result, we presupposed that the nasal septum perforations of welders were due to chronic exposure to low level hexavalent chromium and/or nickel, and report these cases with literatures review.
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