수필:광복30주년을 맞아,정상과 이상,작가정신과 고강의 예술,처녀무당,국화향기어린 내 고향,산토끼

강영숙,홍선희,윤애근,김주원,김순영,리후안누 북한연구소 1975 北韓 Vol.- No.46

내인성물질의 수송계를 이용한 혈액 - 뇌관문에의 약물송달 V : 약물의 혈액 - 뇌관문 투과성에 대한 염기성 아민 및 모노카르본산 수송계의 역할 A Role of Amine and Monocarboxylic Acid Carrier Systems for the Drug Transport

강영숙 한국약제학회 1990 Journal of Pharmaceutical Investigation Vol.20 No.4

The contribution of endogenous transport systems to the blood-brain barrier (BBB) transport of basic and acidic drugs was studied by using a carotid injection technique in rats and an isolated bovine cerebrovascular disease state were compared between the normotensive rats (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP) which have been well established as an animal model with pathogenic similarities to humans. Basic drugs such as eperisone, thiamine and scopolamine inhibited, in a concentration dependent manner the in vivo uptake of [³H]choline through BBB, whereas amino acids and acidic drugs such as salicylic acid and valproic acid did not inhibit the uptake. The uptake of [³H]choline by B-CAP increased with time and showed a remarkable temperature dependency. The uptake of [³H]choline by B-CAP showed the very similar inhibitory effects as observed in the in vivo brain uptake, and was competitively inhibited by a basic drug, eperisone. The in vivo BBB uptakes of [³H]acetic acid and [^(14)C]salicylic acid were dependent on pH of the injectate and the concentration of drugs. Several acidic drugs such as salicylic acid, benzoic acid and valproic acid inhibited the in vivo uptake of [³H]acetic acid, whereas amino acid, choline and a basic drug such as eperisone did not inhibit the uptake. The uptake of acetic acid by B-CAP was competitively inhibited by salicylic acid. The permeability surface area product (PS) through BBB for [³H]choline in SHRSP was significantly lower than that in WKY. The concentration of choline in the brain dialysate in SHRSP was about half of that in WKY, while no significant difference was observed in the plasma concentration of choline between SHRSP and WKY. No significant difference was observed in the transport of monocarboxylic acids, glucose and neutral amino acid through BBB between SHRSP and WKY. From these results, it was concluded that BBB transport system of choline contributes to the transport of basic drugs through BBB, that acidic drugs can be transported via a moncarboxylic acid BBB transport system and that the specific dysfuntion of the BBB choline transport in SHRSP was ascribed to the reduction of the maximum velocity of choline concentration in the brain interstitial fluids.

화학적 및 유전공학적으로 제조한 뇌송달 벡터의 뇌수송량 비교

강영숙,서경희 한국약제학회 1999 Journal of Pharmaceutical Investigation Vol.29 No.2

Drug delivery to the brain may be achieved by producing chimeric peptide, attaching the drug to protein "vectors" which are transported into the brain from the blood by a receptor-mediated transcytosis through the blood-brain barrier (BBB). Since the BBB expresses high concentrations of transferrin receptor, and it was reported that anti-transferrin receptor mouse monoclonal antibody (OX26) undergoes transcytosis through the BBB, it is logical to assume that a drug delivery system via transferrin receptor-mediated transcytosis is a promising strategy. In the present study, therefore, we tested feasibility of several OX26 based vectors for the brain delivery of a model drug. Avidin-based delivery vectors such as OX26-streptavidin (OX26-SA), OX26-neutralite avidin (OX26-NLA) were chemically synthesized vectors and OX26 immunoglobulin G 3 type C_H3 fusion avidin (OX26 IgG3C_H3-AV) was genetically engineered. To improve the efficiency of producing chimeric peptide, we used avidin-biotin technology. Pharmacokinetics of [³H]biotin bound to OX26-SA, OX26-NLA and OX26 IgG3C_H3-AV was determined by intravenous injection technique, and their stabilities in plasma were analyzed using HPLC. The brain delivery of [³H]biotin bound to OX26-SA, OX26-NLA and OX26 IgG3C_H3-AV (expressed as %ID/g brain) was 0.22±0.01, 0.18±0.01 and 0.25±0.09, respectively. The areas under the plasma concentration versus time curve (AUC) for OX26-SA, OX26-NLA, OX26 IgG3C_H3-AV from time zero to 60 min were 209±10, 195±9, 134±29 %ID·min/㎖, respectively and their total clearances (CL_(tot)) were 1.00±0.09, 1.08±0.07 and 1.54±0.29 ㎖/min/㎏, espectively. These results showed that these vectors possess preferable pharmaceutical (e.g., resonable stability) and pharmacokinetics (e.g., significant brain uptake and enhanced AUC) for brain delivery. Therefore, these vectors may be broadly useful in the brain delivery of drugs that are not transported into the brain to a significant extent.

韓日両言語におけるアルファベット頭文字語のアクセント研究 − 釜山方言と鹿児島諸方言を中心に −

강영숙 대한일어일문학회 2019 일어일문학 Vol.83 No.-

The purpose of this study is to clarify the accent pattern of alphabetic acronyms like ‘ID and CNN’ and alphabetic compounds of Korean Busan dialect. This study would also like to clarify the difference between the accent pattern of alphabetic acronyms in both Kagoshima dialects of Japan and Busan dialect of Korean. Accents of the Busan dialect alphabetic acronyms are largely divided depending on whether the first element is a monosyllable or polysyllable. In the case of beginning with a monosyllable, the words are pronounced “HHL…” regardless of the accent of the following element. In the case of beginning with a polysyllable, the acronyms are pronounced “first syllable start low, go high from the second syllable to high until the accent of the final element (LH… or LH…HL)”. Unlike the foreign words accent rules and compound word accent rules, the accent of alphabetic acronyms follows its own accent rules. This point is different from the accent of the alphabetic acronyms of Kagoshima dialects of Japan, which is concerned with the accent of loanwords or compound words.

韓國語の慶尙南道方言のアクセント體系 -蔚山方言,巨濟島方言を中心に-

강영숙 대한일어일문학회 2005 일어일문학 Vol.28 No.-

This paper investigates the accent systems of the Ulsan dialect, located in the eastern Gyeongsangnamdo, and of the Geoje dialect, located in the western Gyeonsangnamdo. The Ulsan dialect shows an n+1-way opposition for words of n syllables. The Geoje dialect shows an n+2-way opposition for words of three or fewer syllables and an n+1-way opposition for words of four or more syllables. This dialect has the property of accent kernel and word tone.

암세포 표적지향화를 위한 항체-엔도스타틴 융합단백질의 체내동태 및 종양으로의 이행성

강영숙,이나영 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.4

A novel antitumor agent, antibody-endostatin fusion protein (anti-HER2/neu IgG3C_(H)3-Endostatin, AEFP) formed by genetic engineering procedure from antibody (Ab) which specifically targets to tumor cells and angiogenesis inhibitor, endostain (Endo) that has excellent antitumor effect, minimizes the toxicity of normal cells and selectively kills only tumor cells. The purpose of this study is to evaluate the pharmacokinetic parameters and to analyze the localization of AEFP. After an intravenous injection of 150μl (5μCi)[^(125)I]Ab,[^(125)I] AEFP to mice, blood was collected through retroorbital plexus from 15 min to 2880 min. Following the jugular vein injection of 150μl (10μCi)[^(125)I] Endo, blood was collected by the use of carotid artery cannulation from 0.25 min to 30 min. Cosequently, Endo was very rapidly removed from plasma compartment whiin 30 min. On the other hand, AEFP similar to Ab was slowly cleared from plasma. Also, Endo was metabolized about 40% within 30 min. However, AEFP was shown to metabolize less than 10% within 2880 min. The organ distribution of Endo was in order kidney, lung, spleen. Both Ab and AEFP were localized in order spleen, kidney, liver. Futhermore the tumor/blood distribution ratio of AEFP at 96 hours after injection is about 20 times higher than it of Endo at one hour after injection. In conclusion, theses studies demonstrate that the anti-cancer or suppression of angiogenesis effect of Endo may be improved by the use of AEFP because the longer half life and stability of AEFP is able to selectively target antigens expressed on tumors.

최근 외국인 투자자금 유출입 및 외화자금시장 점검 (9.8)

강영숙 국제금융센터 2015 국제금융 Vol.2015 No.10

코로나19 사태와 예배

강영숙 서울성경신학대학원대학교 2009 성경신학저널 Vol.11 No.-

사회복지조직의 규모의 확대(1) : 조직운영의 이점인가?

강영숙 한국자치행정학회 2014 한국자치행정학보 Vol.28 No.1

본 연구는 다수의 사회복지법인들이 산하 사회복지기관의 수를 증가시켜 법인조직의 규모를 확대해서 운영하 는 것을 어떻게 이해할 것인가? 라는 질문에서 시작된다. 구체적으로 법인조직의 규모의 확대가 법인조직운 영에 이점을 주었는지를 탐색적으로 알아보고자 한다. 이에 본 연구에서는 질적 연구방법의 하나인 내러티브 탐구방법을 활용하였다. 연구자는 법인조직 관리자들의 회고를 통하여, 법인조직 산하 사회복지기관의 수를 증가시켜 법인조직의 규모를 확대한 것이 법인조직운영에 이점이 있었는지를 탐색적으로 살펴보았다. 연구 분석 결과는 다음과 같다. 사회복지법인의 산하시설 수의 증가를 통한 규모의 확대는 '미션과 가치 유지 및 확대', '미션과 가치유지를 위한 전략수립', '조직구성원의 성장을 위한 법인의 다각적 활동', '인재 확보 및 관리 노력', '법인조직운영의 표준화', '이사회구성원의 전문성’, ‘이사회운영의 공정성', '참여적 의사결정구조 ', '대상자 욕구증가와 참여대상자 수의 증가', '재정확보를 위한 노력의 확대', '재정 관리의 투명성', '전문성 강화를 위한 노력', ‘대상자 욕구측정을 위한 정보관리’ 그리고, '공익성 추구의 노력 결과'로 범주화되었다. 분 석된 14가지 하위차원은 '법인미션과 가치의 확대', '역량있는 인적자원 확대', 조직운영 공정성 확대', '대상 자의 확대', '재원의 확대', '전문성의 확대' 그리고 '공익성의 확대'로 총 7개의 상위차원으로 범주화되었다.

일본 탐정업계의 운용 현황과 문제점 분석

강영숙 한국경찰연구학회 2014 한국경찰연구 Vol.13 No.4

공인탐정제도는 사실관계조사ㆍ확인 등의 합법적인 정보수집 서비스를 통해 국민의 정보수집 수요의 필요욕 구 충족, 전문적 일자리 창출, 국제탐정시장의 경쟁력 제고, 국가 치안기관의 한계 보완, 탐정관련 불법행위 방지 등 국가경제 및 사회치안 유지 및 발전에 크게 기여하고 있다, 우리나라도 한국 실상에 맞는 공인탐정제 도 도입과 정착 및 발전을 위해 입법계, 학계, 법무부․경찰기관이 각자 오랫동안 노력해 왔고, 2013년에는 정부 의 ‘신직업 발굴․육성 추진방안’ 중 탐정(민간조사원)업’에 대해서 구체적인 도입방안을 추진함에 따라 합법적 인 탐정제도의 실질적인 필요성은 매우 높아 졌다. 이와 같은 시대적 필요상황에 따라 본 연구는 2007년부터 시행 된 일본 탐정업법, 일본 탐정업계의 운용실태 및 현실적 부작용 등 탐정업계의 문제점을 중심으로 관련 자료를 분석․연구하였다. 연구 결과 일본 탐정업계의 대표적인 문제점은 탐정업법 위반업자의 증가, 탐정업과 관련 된 타 법령 위반의 문제점, 탐정관련 협회의 난립, 탐정업계의 과대 및 허위광고 문제점, 의뢰비용 분쟁 증가, 일본 탐정업 종사자의 사회적 지위와 전문성의 문제점 등으로 나타났다. 이를 바탕으로 추후 한국 실상에 맞는 탐정제도 도입에 대해 다음과 같은 시사점을 들 수 있다. 첫째, 우리나 라의 탐정법의 입법과 제도시행에서 탐정의 업무범위, 타 법률과의 관계, 위법행위 시 처벌 조항, 탐정의 자격 및 결격사유, 탐정의 의무사항 등 분야별 내용을 명확히 규정하여 부작용을 최소화하여야 한다. 둘째, 제도 시행과정에서 나타난 부작용과 부실업자, 위법행위자들에 대해 관할기관의 철저한 관리감독과 함 께 탐정업무 종사자는 물론 탐정업무 관련협회의 자성과 노력 등이 필요하다. 셋째, 일본탐정업계의 문제점에 서도 지적된 바와 같이 추후 탐정업자의 계약위반, 조사의뢰비용에 관한 의뢰인(소비자) 간의 분쟁 및 해결방 안에 대해서는 제도 도입 전부터 충분한 사전조사와 대책 및 탐정업무 의뢰비용의 적정화 추진도 함께 강구해 야할 것이다. South Korea has gratified the needs for fact relevance research and confirmation tasks through collection of its nation's information and contributed to the nation's protection of human rights, national economy and maintaining the public order for a long time. It has put an effort on introduction, settlement and development of the future official detective system that corresponds with the actual situation in Korea by minimizing infringement of privacy and side effects of the detective system. In 2013, as a part of government employment improvement and creating new jobs, it is promoting a detailed introduction for 'Detective business (private detective)' among the 'discovery of new jobs and their promotion plan'. Following such periodic circumstance and the practical necessity, the research analyzes Japan Private Detective Act enforced in 2007 according to the need for management and regulation on Japanese Detective Business, and the associated materials focusing on the problem of detective business observed due to the current operation of the business and its practical side effect. The major problems of Japanese Detective Business include the increase of detective business violators, infringement of other laws, unlicensed establishment of detective association and increased dispute on commission fee.