http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
오늘 본 자료
瀉白散 추출물에 의한 인체 폐암세포의 Apoptosis 유도 기전에 관한 연구
이재훈,강병령,감철우,박동일,최영현 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.2
We investigated the effects of Sabaek-san (SBS) water extract on the growth of human lung carcinoma A549 cells. Upon treatment with SBS extract, a concentration-dependent inhibition of cell viability was observed and cells developed many of the hallmark features of apoptosis, including condensation of chromatin. Flow cytometry analysis confirmed that SBS treatment increased populations of apoptotic-sub Gl phase. In addition, proteolytic cleavages of poly(ADP-ribose) polymerase and β-catenin protein were observed after treatment of SBS extract. These apoptotic effects of SBS in A549 cells were associated with marked inhibition of Bcl-2 and Bcl-xL mRNA in a dose-dependent manner, however the levels of Bax expression were not affected. SBS treatment also induced a proteolytic activation of caspase-3, which is believed to play a central role in the apoptotic signaling pathway. The previous and present results indicated that SBS-induced inhibition of lung cancer cell proliferation is associated with the blockage of G1/S progression and the induction of apoptosis.