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Cephradine Lysinate의 생체내 이용율에 관한 연구
梁在憲,韓順天 又石大學校 1990 論文集 Vol.12 No.-
Cephradine is a new semisynthetic cephalosporins with antibacterial activity against gram positive and gram negative pathogenic microorganisms. Since cephradine and cephalexin are water insoluble Preparation for parenteral administration have previously been in the from of aqueous solution of an alkali metal more particularly sodium or potassium salt. but such solutions have in variably caused pain and side action when administered by in Jection. In order to increase the bioavailability of cephradine, the lysine salt of cephradine was prepared and compared with cephradine by determining solubility, dissolution rate, absorption rate of small intestine, blood concentration and antibacterial effect. The experimental results were summarized as followings. 1) The solubility of cephradine lysinate was increased by about times in water compared with that of cephradine. 2) The dissolution rate of cephradine lysinate was increased by about two times in simulated gastric fluid, intestinal fluid and pH 4.5 buffer solution compared with cephradine. 3) Cephradine lysinate showed about 50% higher absorption rate in small intestine than that of cephradine. 4) Blood concentration of cephradine lysinate was higher than of cephradine until 60minutes after oral administration. 5) Cephradine and cephradine lysinate have same antibacterial activity by the cylinder method. While, antibacterial activity of cephradine lysinate was higher than that of cephradine by the tablet disc method.
삼백초 Ethyl acetate 분획물의 예쁜꼬마선충 내의 항산화 효과
이은별,김준형,이재광,한순천,박현미,김대근 한국생약학회 2017 생약학회지 Vol.48 No.1
Saururus chinensis (Lour.) Baill. (Saururaceae) has been used as a traditional medicine for the treatment of dysuria, leukorrhea, eczema, jaundice and ascites in Korea, China and Japan. Ethanol extract of S. chinensis was successively partitioned as methylene chloride, ethyl acetate, n-butanol and H2O soluble fractions. Among those fractions the ethyl acetate soluble fraction showed the most potent DPPH radical scavenging and superoxide quenching activities. To verify antioxidant activities of ethyl acetate fraction, we checked the activities of superoxide dismutase (SOD) and catalase, and intracellular ROS level and oxidative stress tolerance in Caenorhabditis elegans. Furthermore, to see if increased stress tolerance of worms by treating of ethyl acetate fraction was due to regulation of stress-response gene, we quantified SOD-3 expression using transgenic strain. Consequently, ethyl acetate fraction elevated SOD and catalase activities of C. elegans, and reduced intracellular ROS accumulation in a dose–dependent manner. Moreover, ethyl acetate fraction-treated CF1553 worms exhibited significantly higher SOD-3::GFP intensity.