고혈압의 응급치료로서 刺針이 혈압에 미치는 영향

한명아,김동웅 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.4

It was recognized in the previous studies that electric muscular stimulation or electric acupuncture affected on the sympathetic nerve activities, and especially blood pressure was decreased to statistically significant value in the hypertension patients. But those electric acupuncture effect was controversial in other studies. In this study, we investigated the effects of systemic acupuncture and ear acupuncture combined with systemic acupuncture on blood pressure. When patients first visited to emergency room(ER) of Oriental Medicine Hospital of Wonkwang Oriental Medical School, blood pressure was checked. Then systolic pressure was more than 180mmHg and diastolic blood pressure was more than 90mmHg, the patient was included into Systemic acupuncture group. During admission day, if the same patient was checked again high blood pressure(borderline was same to ER), then included into ear acupuncture combined systemic acupuncture group. And same patient was checked again high blood pressure(borderline was same to ER), then included into control group. In this way fifteen patients was included into this study. In systemic acupuncture group, ear acupuncture combined with systemic acupuncture group and control group, systemic blood pressure was commonly decreased at 50minutes, 60minutes, 120minutes after the baseline in statistical significance value. But diastolic blood pressure was not changed in statistical significance. Compared to control group, systemic acupuncture group or ear acupuncture combined with systemic acupuncture group had not revealed more significant change in blood pressure. There was no therapeutic superiority of systemic or ear acupuncture on high blood pressure control to non-acupuncture group.

서울시 노인돌봄종사자의 직업만족도 연구

한명이 한국노인복지학회 2023 한국노인복지학회 학술발표논문집 Vol.2023 No.5

농촌형 치매 안심마을 사업이 지역주민의 치매 인식도, 인지기능, 우울감에 미치는 영향 :

한명일(Myeong-Il Han),김경민(Gyung-Min Kim),오지영(Ji-Young Oh),박미경(Mi-kyeong Park),강남인(Nam-In Kang),김재원(Jae-Won Kim) 대한노인정신의학회 2018 노인정신의학 Vol.22 No.1

Objective:According to the 3rd Korean National Dementia Plan, the dementia-friendly community initiative was launched. The aim of this study was to evaluate the effects of a rural dementia-friendly village project on the participants. Methods:Jeollabukdo Provincial Dementia Center designated Sosu-maeul, located in Buan-gun Jeollabuk-do, as a rural dementia-friendly village. We conducted dementia partnership education, youth-elder matching activity, and cognitive enhancing program. The efficacy of this project was evaluated by the changes in dementia awareness, cognitive function, and depressive symptoms. We used dementia awareness questionnaire, Mini-Mental Status Examination for Dementia Screening (MMSE-DS), and Korean version of Short form of Geriatric Depression Scale (SGDS-K). Results:This study was carried out with 24 residents in this community. There was no significant change in dementia awareness score between pre- and post-intervention (p=0.25). MMSE-DS score was significantly increased from 24.5 to 25.5 (p<0.001) and SGDS-K score was statistically improved from 3.5 to 2.5 (p=0.04) after interventions. Conclusion:We Jeollabukdo Provincial Dementia Center carried out a pilot study of a rural dementia-friendly village project. This project led to improvements on cognitive functions and depressive symptoms in the participants. But the improvement of dementia awareness was not achieved. More direct and experiencing interventions for people with dementia are necessary to improve dementia awareness.

노인 환자에서 나타나는 섬망의 임상적 접근

한명일(Myeong Il Han) 대한노인정신의학회 2004 노인정신의학 Vol.8 No.2

Delirium is not uncommon and is a devastating clinical syndrome. Elderly patients are vulnerable to delirium, especially demented or/and medically-surgically ill patients. Old age, comorbid psychiatric, medical and/or neurological diseases, medications, changed pharmacodynamics, sensory impairment and psychosocial stresses contribute to the development of delirium. Delirium in elderly patients is somewhat different from delirium in younger patients, sometimes under detected and/or poorly managed. This review discusses the diagnosis, classification, etiology and treatment, and presents 3 clinical cases of delirium in elderly patients. This review also focuses on a practical approach in assessing and managing delirium in elderly patients. The management of delirium consists of identifying and correcting the underlying problems, including prescribing suitable medication.

Gastric stem cells and gastric cancer stem cells

한명은,오세옥 대한해부학회 2013 Anatomy & Cell Biology Vol.46 No.1

The gastric epithelium is continuously regenerated by gastric stem cells, which give rise to various kinds of daughter cells, including parietal cells, chief cells, surface mucous cells, mucous neck cells, and enteroendocrine cells. The self-renewal and differentiation of gastric stem cells need delicate regulation to maintain the normal physiology of the stomach. Recently,it was hypothesized that cancer stem cells drive the cancer growth and metastasis. In contrast to conventional clonal evolution hypothesis, only cancer stem cells can initiate tumor formation, self-renew, and differentiate into various kinds of daughter cells. Because gastric cancer can originate from gastric stem cells and their self-renewal mechanism can be used by gastric cancer stem cells, we review here how critical signaling pathways, including hedgehog, Wnt, Notch, epidermal growth factor, and bone morphogenetic protein signaling, may regulate the self-renewal and differentiation of gastric stem cells and gastric cancer stem cells. In addition, the precancerous change of the gastric epithelium and the status of isolating gastric cancer stem cells from patients are reviewed.

지역사회의 건강증진을 위한 금연사업의 개선방안

한명이,김노마,Mehta Jaydip Chandrkant 한국디지털정책학회 2012 디지털융복합연구 Vol.10 No.4

캐릭터의 미적요소가 시청 몰입도와 재시청 의도에 미치는 영향 : 중국 사극 드라마<연희공략(延禧攻略)>를 대상으로

한명,윤수미,최혜진,권오혁 한국디지털정책학회 2022 디지털융복합연구 Vol.20 No.1

알츠하이머 치매의 행동심리증상에서 비정형 항정신병약물

한명일(Myeong-Il Han),황태영(Tae-Young Hwang),이지은(Jieun Lee) 대한노인정신의학회 2015 노인정신의학 Vol.19 No.2

AD 환자의 치료에서 BPSD를 조절하는 것은 매우 중요하다. 이를 통하여 환자의 삶의 질을 향상시키고 가족과 수발자 의 부담을 경감시키며 요양시설 등에의 입소를 지연시켜 의료비의 감소를 유도할 수 있다. AD 환자에서 빈발하는 정신증, 초조증상, 그리고 공격성 등의 BPSD 치료에 공인된 약물은 아직 없다. 다만 임상 지침서와 전문가의 의견을 토대로 AAP 가 일차적 선택 약물로 추천된다. AD 환자에서 정신증을 비롯한 BPSD의 치료에 사용되는 risperidone과 aripiprazole의 치료적 효과는 분명하지만 효 과의 정도는 크지 않다. Olanzapine의 치료 효과는 앞의 두 가지 약물에 비해 다소 부족하고, quetiapine은 고용량에서 어느 정도 효과가 있을 것이라고 기대된다. AAP의 사용과 관련하여 흔히 발현되는 부작용으로는 졸림, EPS, 말초 부종 등이 있다. AAP는 인지기능 저하, CVAEs 증가, 그리고 사망률 증가 등의 심각한 부작용을 발생시킨다. 치료 효과는 크 지 않고 부작용은 심각하기 때문에 AD 환자의 BPSD를 치료하기 위해 AAP를 사용하는 경우에는 약물 사용에 따른 편익(benefits)과 위험(harms)을 충분히 비교하면서 접근하 는 것이 중요하다. In addition to cognitive and functional decline, various behavioral and psychological symptoms in dementia (BPSD) are mani-fested in the patients with Alzheimer’s dementia (AD). Some of BPSD, especially psychosis, agitation, and aggression could be challenges to caregivers and clinicians. Atypical antipsychotic drugs (risperidone, olanzapine, quetiapine, and aripiprazole) are widely prescribed to manage complicated neuropsychiatric symptoms associated with AD. It is known that atypical antipsychotics (AAP) have modest and significant beneficial effects in the short term treatment of BPSD. However their safety of AAP has been concerned with potentially increased adverse events. This article reviewed the treatment outcomes and adverse effects of AAP when managing BPSD in the patients with AD. The effects of risperidone and aripiprazole are obvious on psychosis and aggres-sion, but with small effect size. AAP could exacerbate cognitive decline, and it could increase the rate of cerebrovascular accidents and mortality rate in the patients with AD.

COVID-19 환자에서 나타나는 섬망에 대한 고찰

한명일(Myeong-Il Han),김용(Yong Kim),김철응(Choel Eung Kim),최말례(Mal-Rye Choi) 대한노인정신의학회 2021 노인정신의학 Vol.25 No.2

We reviewed the clinical features, prevalence, pathophysiology, and prevention and treatment of delirium in patients with coronavirus disease of 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, has neurotropic properties, and can penetrate the central nervous system and affect brain neurons. These characteristics may explain the fact that COVID-19 patients may be particularly susceptible to delirium. COVID-19 delirium occurred more frequently in intensive care unit and emergency room settings. Patients with neurologic disorders and the elderly were more vulnerable to delirium. Clinical symptoms of COVID-19 delirium may manifest as a hyper/hypoactive type. Prevention and treatment appear to be similar to conventional treatment strategies. And the patient’s feeling of isolation due to social distancing and a highly intensive labor force of medical personnel must be overcome. Melatonin, alpha-2 agonist, antipsychotics, and valproic acid have been recommended for the treatment of delirium symptoms. However, this article did not go through a systematic literature review.

노인환자에서 대뇌질환에 의해 나타나는 섬망

한명일(Myeong Il Han) 대한노인정신의학회 2008 노인정신의학 Vol.12 No.2

There are well known predisposing and precipitating factors for delirium in elderly patients. Although cerebral disease is a major precipitating factor for delirium, the concept of cerebral disease is not clear. Stroke is a typical condition reflecting intracranial change. There are not many studies about delirium post stroke. This paper reviewed delirium post stroke, instead of cerebral disease induced delirium as a whole. The etiology of delirium post stroke is not well established. The neuroanatomical site and the extent of stroke are important risk factors for the development of delirium. In spite of many limitations CAM, DRS, and MMSE are useful evaluating tools for delirium. In some cases of post stroke delirium, it was developed directly by stroke without any additional cause. In other cases there were also medical complications. And in the rest of the cases, there were multiple potential causes for delirium. Although there are not specific preventive interventions for delirium post-stroke, identifying and correcting the underlying stroke, as well as preventing secondary medical complications are important. Multicomponent non-pharmacological interventions are helpful to prevent delirium, and pharmacological methods for treating behavioral symptoms are sometimes necessary. There should be more studies about cerebral disease induced delirium.