부모와의 상호작용과 또래애착에서 정신건강과 공동체의식의 매개효과: 고등학생을 대상으로

한명은,서은희 학습자중심교과교육학회 2024 학습자중심교과교육연구 Vol.24 No.1

Objectives This study analyzed whether the mediating effect of mental health and sense of community was significant in the relationship between parents-children interaction and peer attachment of mid. adolescents, and whether having the multiple mediating effects of parents-children interaction on peer attachment through mental health and sense of community. Methods For the purposes, 6,429 cases, taken from the 7th wave data(high school 2nd year) of KELS2013 were used. A survey of parents-children interaction, mental health, sense of community, and peer attachment was conducted. Bootstrapping analysis was performed using the SPSS Macro Process to examine the mediating effects. Results The direct effects of parents-children interaction, mental health, and sense of community on peer attachment were significant. The each mediating effect of mental health and sense of community was significant in the relationship between parents-children interaction and peer attachment. As s result of analyzing the multiple mediators of mental health and sense of community in the effect of parents-children interaction on peer attachment, a sequential multi-mediation functions appeared between the two variables. Conclusions Parents-children interaction influences mid. adolescents’s peer attachment formation through bolstering mental health and sense of community. This implies that mental health counseling and sense of community training helps the formation of the mid. adolescents’s peer attachment

경제지표를 활용한 다중선형회귀 모델 기반 국제 휘발유 가격 예측

한명은,김지연,이현희,김세인,박민서 국제문화기술진흥원 2024 The Journal of the Convergence on Culture Technolo Vol.10 No.1

The domestic petroleum market is highly sensitive to changes in international oil prices. So, it is important to identify and respond to those changes. In particular, it is necessary to clearly understand the factors causing the price fluctuations of gasoline, which exhibits high consumption. International gasoline prices are influenced by global factors such as gasoline supplies, geopolitical events, and fluctuations in the U.S. dollar. However, previous studies have only focused on gasoline supplies. In this study, we explore the causal relationship between economic indicators and international gasoline prices using various machine learning-based regression models. First, we collect data on various global economic indicators. Second, we perform data preprocessing. Third, we model using Multiple linear regression, Ridge regression, and Lasso(Least Absolute Shrinkage and Selection Operator) regression. The multiple linear regression model showed the highest accuracy at 96.73% in test sets. As a result, Our Multiple linear regression model showed the highest accuracy at 96.73% in test sets. We will expect that our proposed model will be helpful for domestic economic stability and energy policy decisions.

Gastric stem cells and gastric cancer stem cells

한명은,오세옥 대한해부학회 2013 Anatomy & Cell Biology Vol.46 No.1

The gastric epithelium is continuously regenerated by gastric stem cells, which give rise to various kinds of daughter cells, including parietal cells, chief cells, surface mucous cells, mucous neck cells, and enteroendocrine cells. The self-renewal and differentiation of gastric stem cells need delicate regulation to maintain the normal physiology of the stomach. Recently,it was hypothesized that cancer stem cells drive the cancer growth and metastasis. In contrast to conventional clonal evolution hypothesis, only cancer stem cells can initiate tumor formation, self-renew, and differentiate into various kinds of daughter cells. Because gastric cancer can originate from gastric stem cells and their self-renewal mechanism can be used by gastric cancer stem cells, we review here how critical signaling pathways, including hedgehog, Wnt, Notch, epidermal growth factor, and bone morphogenetic protein signaling, may regulate the self-renewal and differentiation of gastric stem cells and gastric cancer stem cells. In addition, the precancerous change of the gastric epithelium and the status of isolating gastric cancer stem cells from patients are reviewed.

오미자탕(五味子湯)이 심근세포에 미치는 영향

한명아,최우정,김동웅,정대영,신선호,최진영,Han, Myoung-Ah,Choi, Woo-Jung,Kim, Dong-Woung,Jung, Dae-Young,Shin, Sun-Ho,Choi, Jin-Young 대한한방내과학회 2002 大韓韓方內科學會誌 Vol.23 No.2

The water extract of Omija-tang(OMJT) has been traditionally used for treatment of ischemic heart and brain damage in oriental medicine. However, little is known about the mechanism by which the water extract of OMJT protects cells from such damage. Therefore, this study was conducted to investigate the protective mechanisms of OMJT on $H_2O_2$-induced toxicity in H9c2 cardiomyoblast cells. Treatment of $H_2O_2$ markedly induced death of H9c2 cardiomyoblast cells in a dose-dependent manner. The characteristics of $H_2O_2$-induced death of H9c2 showed apparent apoptotic features, such as DNA fragmentation. However, OMJT significantly reduced both $H_2O_2$-induced cell death and chromatin fragmentation. The decrease of Bcl-XL expression by $H_2O_2$ was inhibited by OMJT. In addition, the increase of Bcl-XS and Bax expression were also inhibited by OMJT. In particular, Fas expression, which is generally recognized as cell death inducing signal by Fas/FasL interaction, was markedly increased by $H_2O_2$ in a time-dependent manner, whereas this increase was completely prevented by OMJT. The combined treatment of OMJT and $H_2O_2$ in H9c2 cells also reduced activation of caspase-9 and caspase-3 like protease. Taken together, this study indicates that the protective effects of the water extract of OMJT against oxidative damage may be mediated by the modulation of BcI-XL/S and Bax expression by way of the regulation of mitochondrial membrane potential and caspase cascades.

노인환자에서 대뇌질환에 의해 나타나는 섬망

한명일(Myeong Il Han) 대한노인정신의학회 2008 노인정신의학 Vol.12 No.2

There are well known predisposing and precipitating factors for delirium in elderly patients. Although cerebral disease is a major precipitating factor for delirium, the concept of cerebral disease is not clear. Stroke is a typical condition reflecting intracranial change. There are not many studies about delirium post stroke. This paper reviewed delirium post stroke, instead of cerebral disease induced delirium as a whole. The etiology of delirium post stroke is not well established. The neuroanatomical site and the extent of stroke are important risk factors for the development of delirium. In spite of many limitations CAM, DRS, and MMSE are useful evaluating tools for delirium. In some cases of post stroke delirium, it was developed directly by stroke without any additional cause. In other cases there were also medical complications. And in the rest of the cases, there were multiple potential causes for delirium. Although there are not specific preventive interventions for delirium post-stroke, identifying and correcting the underlying stroke, as well as preventing secondary medical complications are important. Multicomponent non-pharmacological interventions are helpful to prevent delirium, and pharmacological methods for treating behavioral symptoms are sometimes necessary. There should be more studies about cerebral disease induced delirium.

Glutamate가 일측 흑질체 파괴 백서의 회전운동에 미치는 영향

한명일,정영철,은홍배,황익근,정상근 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.5

본 연구는 glutamate( , 과 M)가 일측 흑질체를 파괴한 백서에서 apomorphine으로 유도되는 회전운동에 미치는 영향을 알아보고자 하였다. 6-OHDA으로 우측 흑질체를 파괴한후 apomcrphine(0.1mg/kg)을 피하로 주사하면 병소반 대측으로 회전운동이 유발된다(641.7±163.9/hr). Glutamate는 apomorphine으로 유도되는 회전운동을 유의하게 감소시켰다. 그러나 이 glutamate의 감소효과는 GABA 길항제인 bicuculine에 의해 길항 그리고/ 또는 역전되었다. 이상의 실험결과에서 glutamate는 apomorphine으로 유도되는 회전운동을 감소시키고, 그 작용은 glutamate( ∼ M)가 선조체와 흑질체의 GABA 농도를 증가시킴으로써 나타났을 가능성을 시사한다. The aim of this study was to examine the effects of various concentrations of glutamate( , and M) on the circling movement induced by apomorphine in the unilateral substantia nigra-lesioned rats. Subcutaneous apomorphine(0.1mg/kg) elicited contralateral circling movement(641.7±163.9/hr). Glutamate( - M) significantly reduced the numbers of apomorphine-induced circling movement. This reducing effect of glutamate was antagonized and/or reversed by M GABA antagonist bicuculine. These results suggest that glutamate reduces circling movement induced by apomorphine and this reducing effect of glutamate may be mediated by increased GABA concentration in striatum and substantia nigra.

노인 환자에서 나타나는 섬망의 임상적 접근

한명일(Myeong Il Han) 대한노인정신의학회 2004 노인정신의학 Vol.8 No.2

Delirium is not uncommon and is a devastating clinical syndrome. Elderly patients are vulnerable to delirium, especially demented or/and medically-surgically ill patients. Old age, comorbid psychiatric, medical and/or neurological diseases, medications, changed pharmacodynamics, sensory impairment and psychosocial stresses contribute to the development of delirium. Delirium in elderly patients is somewhat different from delirium in younger patients, sometimes under detected and/or poorly managed. This review discusses the diagnosis, classification, etiology and treatment, and presents 3 clinical cases of delirium in elderly patients. This review also focuses on a practical approach in assessing and managing delirium in elderly patients. The management of delirium consists of identifying and correcting the underlying problems, including prescribing suitable medication.

중국 3~6세기 출토 청동 조명도구 연구

韓茗 충남대학교 백제연구소 2021 百濟硏究 Vol.74 No.-

This paper collects the data of bronze lamps unearthed from the 3rd to 6th century in Chinese mainland. According to the difference from the perspective of form, they are divided into eight types: vertical handle lamp, branches-shaped lamp, horizontal handle lamp, pendant lamps, clamshell-shaped lamp, vessel-shaped lamp, candle tray and candle socket, based on which we trying to summarize the evolution of bronze lamps between the end of Han Dynasty to Sui Dynasty. We investigate the general appearance of lamps in the Six Dynasties taking ceramic lamps from the same period as comparison. Although the production of bronze lamps declined after the Han Dynasty, under the background of the rise of porcelain manufacturing industry, lamp decoration showed a strong artistic expression and the influence of foreign culture, especially the rise of lamps for candle, which made the lamps more decorative and full of the new fashion of the times. The wide use of candles promoted the change of lighting fuel, which was the most important reason for the change of the forms of lamps after Han Dynasty. It was the Six Dynasties that was the transition period of ancient Chinese lamps. Starting from the particularity of the lamps from the Six Dynasties, based on the aboved iscussion, this paper discusses the judgment and classification standards of lamps and lanterns in the Han-to-Tang Dynasties period, and points out the complexityof lamp typology and that there remains much to be further explored. 본고는 중국대륙에서 출토된 3~6세기 청동 조명도구를 체계적으로 수집하고 정리하였다. 형태의 차이에 따라 수병등(豎柄燈), 연지등(連枝燈), 횡병등(橫柄燈), 제등(提燈), 녹로등(轆轤燈), 치등(卮燈), 촉반(燭盤), 촉삽좌(燭插座)의 8가지 형식으로 나눌 수 있으며, 이를 통해 한나라 이후부터 수나라 이전까지의 청동 조명도구의 변천양상을 파악해보았다. 또, 동시대의 도자기 조명도구의 형태와 비교하여 육조시대 조명도구의 전체적인 모습을 살펴보았다. 비록 한나라 이후 청동 조명도구 제작이 쇠퇴하였지만, 도자기 수공업이 발달하면서 조명도구 장식에높은 예술적 표현력과 역외(域外) 문화의 영향을 보여준다. 특히 촉삽좌 같은 조명도구의 발전으로 같은시기의 조명도구 장식을 풍부하게 하고 새로운 시대적인 특징도 더하였다. 초(燭)의 보급으로 조명연료가 변하게 된 것은 한나라 이후 조명도구의 형태변화의 가장 중요한 계기이며, 육조시대는 중국 고대 조명도구의 전환기로 되었다. 본고에서는 한당시대(漢唐時代) 조명도구의 연구과 분류기준을 참고하여 육조시대 조명도구의 특별한 성격에 알아보았다. 또한, 현재 조명도구의 형식학적 연구에 대해 복잡한 분류와 자료의 부족에서 문제가 있음을 제시하였다.

COVID-19 환자에서 나타나는 섬망에 대한 고찰

한명일(Myeong-Il Han),김용(Yong Kim),김철응(Choel Eung Kim),최말례(Mal-Rye Choi) 대한노인정신의학회 2021 노인정신의학 Vol.25 No.2

We reviewed the clinical features, prevalence, pathophysiology, and prevention and treatment of delirium in patients with coronavirus disease of 2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, has neurotropic properties, and can penetrate the central nervous system and affect brain neurons. These characteristics may explain the fact that COVID-19 patients may be particularly susceptible to delirium. COVID-19 delirium occurred more frequently in intensive care unit and emergency room settings. Patients with neurologic disorders and the elderly were more vulnerable to delirium. Clinical symptoms of COVID-19 delirium may manifest as a hyper/hypoactive type. Prevention and treatment appear to be similar to conventional treatment strategies. And the patient’s feeling of isolation due to social distancing and a highly intensive labor force of medical personnel must be overcome. Melatonin, alpha-2 agonist, antipsychotics, and valproic acid have been recommended for the treatment of delirium symptoms. However, this article did not go through a systematic literature review.

캐릭터의 미적요소가 시청 몰입도와 재시청 의도에 미치는 영향 : 중국 사극 드라마<연희공략(延禧攻略)>를 대상으로

한명,윤수미,최혜진,권오혁 한국디지털정책학회 2022 디지털융복합연구 Vol.20 No.1