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한규원,정낙신,김길수 梨花女子大學校 藥學硏究所 2000 藥學硏究論文集 Vol.- No.9
In order to assay the efficacy of newly synthesized antiviral compounds, pyrimidine analogs, pharmacokinetics of those were established as compared with already marketed zidovudine. Zidovudine (15, 20, 25 and 35 ㎎/㎏), LJ142 (18.52 ㎎/㎏) and LJ143 (15, 18.52 and 30 ㎎/㎏) were administered orally and intravenously in rats, blood samples were collected post-injection(i.e., for 360 min) at appropriate time intervals. Those were analyzed by HPLC with UV detection at 265 ㎚. Pharmacokinetic parameters (C_max, T_(1/2) MRT, AUC, AUMC, Vd_ss, Cl_t) were calculated. AUCs of zidovudine and LJ143 following I.V. dosing of 15∼25 ㎎/㎏ and 15∼18.18 ㎎/㎏ were dose-independent, However, AUCs of zidovudine and LJ143 following I.V. dosing of 25∼35 ㎎/㎏ and 18.18∼30 ㎎/㎏ were dose-dependent. The relative bioavailability of zidovudine, LJ142 and LJ143 following oral administration were 61.94, 46.44 and 78.24%, respectively.
韓奎元 又石大學校 1984 論文集 Vol.6 No.-
Japanese imperialist extremly practised a private school suppression policy under the cloak of realization of their sphere of a Great East Asia mutual prosperity at the end of a colonialism about Korea. So, it practised prohibition and suppression of students activities, expulsion of a school purposely or exacted to convert a private school into public school Especially it exacted worshiping of schrine from mission school