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- 저자 : 陳聖太 (검색결과 44 건)
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정신분열병 양성 및 음성증상과 혈소판 Monoamine Oxidase 활성도
윤성환,김영훈,진성태 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.1
The intention of this study to investigate the relationship between the activity of platelet MAO and positive and negative symptoms in the male chronic schizphrenics by DSM-III. The authors devided the male chronic schizophrenics into positive, mixed and negative subgroups by Andreasen & Olsen Criteria(1982), and also each patient was evaluated in relation with positive and negative symptom scales proposed by Lewin & Meltzer(1984). The authors assayed kinetic constants(Vmax and Km) for platelet MAO from 22 drug-free schizophrenics and 22 normal controls, radioenzymatically using 14C-benzylamine as a substrate. The results were as follows ; 1) Schizophrenic subjects had a lower mean Vmax Value(5.20±1.58 nmoles10(-6) platelets/hr) and Km value(38.92±19.28×10(-6)M) for poatelet MAO than normal controls(8.07±4.54, 49.56±18.48). Authough lower mean Vmax had a statistical significance, Km did not have. 2) In case of paranoid group(n = 6), there were no statistical differences in kinetic constants for platelet MAO compared with non-paranoid group(n = 16). 3) There were no significant differences in kinetic constants for platelet MAO between positive, mixed and negative symptom group. 4) The difference between kinetic constants for platelet MAO and positive symptom scale and negative symptom scale were not significant statistically. 5) Each scale item in the negative symptoms was not significantly different from platelet MAO activity. Finally, we confirmed that activity of platelet MAO was lowered in chronic schizophrenics, but we did not find any possible relationship between the negative symptom of schizophrenia and kinetic constants for platelet MAO.
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陳聖太 大韓神經精神醫學會 1972 신경정신의학 Vol.11 No.3
The author reported a clinical case of marihuana induced psychosis following the general consideration about marihuana itself-canabis sativa. Hallucinogens such as LSD, mescline, psilocybin etc. have not been the problem socially as well as medically in Korea up to the present time except marihuana which seems to have recently been used by some Korean residing near the U.S. Army camp. It appears that marihuana is a comparatively mild intoxicant in ordinary preparation without causing physical dependence or tolerance. Upon reviewing literatures regarding marihuana psychosis, one can note two different opinions about marihuana psychosis in terms of it's causation. Some earlier investigators insisted that marihuana can induce psychosis directly, but most of others did not agree that marihuana can produce functional psychathology or psychosis but can mostly precipitate it in persons so predisposed. The patient presented in this paper is a 24 year old waitress who became psychotic after rather persitent use of marihuana of 6 weeks' duration(one to two cigarrete a day) to relieve feeling of depression with separation anxiety. She was found to have been hysterical and emotonally unstable person associated with borderline mental retardation (total IQ; 82) prior to her becoming psychotic. It is probable that psychosis in this case is due to her excessive marihuana smoking behavior as precitating factor on the top of the pre-existing personality disorder with mental subnormality as prediposition. In terms of treatment she was successfully managed with a protective and supportive millieu in conjunction with pharmacotherapy (chlorpomazine 200-600mg per day) in acute and subacute phase of her illness. Since the patient has had long-standing personality deficit and subnormal intelligence she will have to be treated with long term supportive psychotherapy with medication as neceassary.
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陳聖太 고신대학교 의학부 1985 高神大學校 醫學部 論文集 Vol.1 No.1
The author presents a clinical experience on 116 new child psychiatric patients seen at outpatient department, Kosin Medical College and Pusan Gospel Hospital during the period of 12 months (May 1, 1983-April 30, 1984). The results are as follows : 1) As to the sources of referral 60 patients(51.7%) were brought in by either parents or relatives and the referral from pediatricians was 27.6% and the consultation from other departments was also considerable(14.7%). 2) In Age and Sex distribution 73 patients(62.9%) were school-age children and among them the most frequent age group was 9-12 years of age. The male : female sex ratio was 65 : 35 which almost coincides with other reports. 3) The clinical symptoms were divided into 8 major categories, i. e., symptoms manifested in behaviors, somatic symptoms, convulsion, speech disturbances, developmental delays, learning disabilities, and sleep disturbances. Among them behavioral symptoms were most frequently found(31.9%) followed by somatic symptoms(26.8%), and convulsion(20.7%). The bizarre and aggressive symptoms were most prevalent behavior symptom. The headache was the most common single symptom among somatic symptoms. 4) The Diagnstic Distribution reveals that the neurotic anxiety state was the most prevalent(18.1%) followed by convulsive disorder (16.4%), enuresis(6.0%) and infantile autism(5.2%). Psychophysiologic disorder, Adjustment disorder, Conduct disorder, Hyperkinesis with developmental delays were 4.3% respectively. The so called Combined disorders such as Convulsive disorder with developmental delays or hyperkinesis, Hyperkinesis with developmental delays were 8.6%. 5) In the Age Distribution of main diagnostic categories Psychoses, Hyperkinesis, and Mental Retardations were evenly distributed in all age groups. However,9-12 age group was most commonly afflicted with neurotic anxiety disorders followed by 13-15 age group. The Convulsive disorders were frequent in the 9-15 years of age and Hyperkinesis and Conduct disorders were more prevalent in the 3-12 years of age as in Special Smptoms. 6) As far as the Treatment is concerned the outpatient treatment was the main therapeutic approaches which include pharmaco-therapy, counseling and education for parents, individual psychotherapy, and/or various combinations of them. The author feels that the diapgnosis and treatment of child psychiatric patients greatly depends on the consultation and liasion from/or with pediatric services and other related departments and we also need to work with para-professionals such as clinical psychologists, social workers, child psychologists, etc. to do so called team approaches which is sine qua non in terms of doing proper work in the field of child and adolescent psychiatry.
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