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RISS 인기검색어
- 검색키워드
- 저자 : 趙世煥(Sae Hwan Cho) (검색결과 6 건)
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趙世煥,洪善憙 慶北大學校 醫科大學 1973 慶北醫大誌 Vol.14 No.2
Glucagon이 histamine에 對한 胃液分泌反應에 미치는 影響을 觀察하기 爲하여 13마리의 雜種成犬을 Pavlov pouch群(6마리)과 Heidenhain pouch群(7마리)으로 나누어 histamine을 皮下 또는 持續靜注하여 胃液分泌를 刺戟한 狀態에서 glucagon을 靜注하여 胃液分泌量, 遊離酸度, 血糖 및 血淸 calcium値를 測定한 結果를 要約하면 다음과 같다. Histamine投與로 顯著하게 增加된 胃液分泌量과 遊離酸度는 glucagoa投與로서 減少하는 傾向이 있었으나 全體的으로 보아 有意한 것은 아니었으며 Pavlov pouch群과 Heidenhain pouch群과의 差異는 볼 수 없었다. Glucagon投與로서 血糖量이 增加하였을 때 胃液分泌가 減少하였으나 血糖量 增加와 胃液分泌減少는 比例하지 않았던 것으로 보아 血糖量 增加가 胃液分泌抑制의 直接的 要因은 아니라고 生覺되며 Pablov pouch群과 Heidenhain pouch群 사이에 特別한 差異가 없었든 事實은 胃液分泌抑制가 迷走神經作用에 起因하는 것이 아님을 推測케 하였다. Glucagon投與는 血淸 calcium 濃度에 影響을 주지 않았으며 glucagon에 依한 胃液分泌抑制는 血淸 calcium과 關係가 없는 것으로 생각되었다. Glucagon, the hyperglycemic glycogenolytic hormone, has been shown to inhibit the basal secretion, acid output and secretion induced by meals, sham feeding, insulin, gastrin and distention of the pyloric antrum both in man and in the experimental animal. However, the precise mechanism of its inhibitory action on gastric secretion is unclear and the effect on histamine loducod gastric secretion ifs controversial. In addition, glucagon has been known to decrease the concentration of serum calcium and it might be speculated that lowered and it might be speculated that lowered serum calcium level plays a role to suppress the gastric secretion. This experiment was undertaken to observe the effect of glucagon on histamine stimulated gastrie secrotion and the concentration of serum calcium in the dog. The experiments were performed on seven denervated Heldenain pouch and six innervated Pavlolv pouch dogs. In one experimental group, glucagon was given continously intraveneously for an hour after subcutanous injection of histamine twice at 30 minutes interval in the other, same administration of glucagon was done two hours after the initation of continous infusion of histamine which was continued for three hours. Gastric juice was collected for every 30 minutes and the gastric secretory rate and acid output were measured. Blood sugar and serum calcium were determined ever half an hour. The following results were obtained: 1. After the adminstration of glucagon, marked hyperglycemia was observed and the gatric secretory rate and acid output were considerably reduced in both Heidenhain and Pavlov pouch dogs, however, there was no prallelism between the increase in blood sugar and the reduction of gastric secrection. 2. No significant difference between innervated and denervated pouch dogs in an inhibitory effect on gastric secretion was noted. 3. The concentration of serum calcium was not changed by glucagon. 4. As result, it is suggested that hyperglycemia or serum calcium level is not a primary factor and vagal nerve is not involved in an inhibition of gastric secretion which was induced by glucagon.
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李澈相,鄭俊謨,趙世煥,李泰淑,孫泰重,洪善熹,鄭克守 慶北大學校 醫科大學 1971 慶北醫大誌 Vol.12 No.1
The 56year old man entered with epigastric distress and generalized edema. His hemoglobin level was 10.6gm%, and the stool test revealed occult blood+. Serum protein level was 3.4gm%, albumin 1.6gm% and globulin 1.8gm%. Upper gastrointestinal series showed a pattern of multiple polyposis and confirmed by gastrocamera and gastrofiberscopic exmination. Gastrectomied specimen showd of multiple polyposis, over 120 in number and varying size ranging mostly from 0.5-1.0㎝. The tip of a large polypoid mass at antrum (6.0×6.0㎝) was ulcerated, and microscopic study of this tumor revealed malignant change, while extensive histological study of the rest of disseminated polyps showed no cancerous lesions. Following subtotal gastrectomy, the serum protein and albumin increased to 5.3gm% and 2.8gm% respectively and discharged on 32th post-op, day.
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