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妊娠中毒症을 同伴한 妊産婦 및 新生兒 血淸 Immunoglobulins에 關한 硏究
薛弘烈,金善行,洪性鳳 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.1
It has long been considered that toxemia of pregnancy might be an immunologic process and this study was designed to explore possible abnormalities in the immunologic process in toxemic pregnant women. IgG. IgA and IgM were measured by radial immunodiffusion plate technique in maternal and umbilical cord sera of toxemic patients and in normal pregnant cases at the time of delivery. The values obtained in the toxemic patients were compared with those from the normal term pregnant women, and the following results were obtained. 1. The level of IgG in maternal sera of toxemic group mere significantly decreased than that of the normal pregnant group. (p<0.05) 2. The levels of IgA and IgM in maternal sera demonstrated no significant difference between normal pregnant and toxemic patients. 3. Though the levels of IgG and IgA in cord sera of toxemic patient were slightly lower than those of the normal pregnant group, the difference was not statistically significant. 4. The level of IgM in cord sera of toxemic group was markedly lower than that of normal pregnant group and the difference was statistically significant. (p<0.05)
薛弘烈,李壽鍾 고려대학교 의과대학 1980 고려대 의대 잡지 Vol.17 No.1
Clinical observations on 187 cases with carcinoma of uterine cervix over a period extending from January 1974 to September 1979 were made statistically. The results were as follows: 1) Among those 187 cases, 182 cases (97.3%) were squamous cell carcinoma of which 8 cases (4.3%) were carcinoma in situ, 6 cases (3.2%) were microinvasive carcinoma and 168 cases (89.8%) were invasive carcinoma. The adenocarcinoma was noted only in 5 cases (2.7%). 2) The average age of the patients with squamous cell carcinoma was 48.0 years old and 42.4 years old in cases with carcinoma in situ, 42.8 in microinvasive carcinoma, 48.5 in invasive caricnoma. The mean age of patients with adenocarcinoma was 47.6 years old. 3) Groups of women in cities showed greater incidence of cervical carcinoma than groups in rural areas did. 4) The peak age incidence of menarche in patient with cervical carcinoma was 17 years old (40%), that of marriage between 19 and 21 (35.2%), that of first delivery between 21 and 23 (52.2%), and that of menopause 48.5 (29.9%). 5) Women with 5 or more pregnancies showed 73.2% in incidence and those with 3-7 deliveries showed 76.1% in incidence. The average number of those was 6.0 and 4.5 times, respectively. 6) Clinical symptoms of the patients with cervical carcinoma were as follows : irregular vaginal bleeding (46.9%), foul discharge (33.5%), lower abdominal pain (13.4%), and contact bleeding (12.3%). Duration of chief complaints was most commonly less than 5 months (69.2%). 7) Gross findings of uterine cervix were as follows : erosion (40.0%), eversion (28.6%), and ulceration (10.3%). 8) According to the clinical stage, the result showed stage O(4.3%), stage Ⅰ (12.3%), stage Ⅱ (51.3%), stage Ⅲ (30.0%) and stage Ⅳ (2.1%). 9) The degree of class on Pap's smear increased with the advancement of cervical cancer. 10) Cell types in invasive squamous cell carcinoma were as follows: large cell non-keratinizing was 50.4%, keratinizing 29.3% and small cell type 20.3%. 11) Clinical stages of the squamous cell carcinoma were correlated with the histologic cell types.