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농존지역 거주노인의 연령,성별,교육수준이 한국판 MMSE 점수에 미치는 영향에 관한 연구
우종인,이정희,홍진표 대한신경정신의학회 1996 신경정신의학 Vol.35 No.1
In order to observe the sociodemographic effects on Mini-Mental State Examination-Korean version(MMSE-K), MMSE-K was administered to the residents aged 65 and older in Yonchon county, Kyungki-Do. Following results were found : 1) Forty percent of the variance in MMSE-K scores was accounted by educatonal level, age and sex. 2) Educational levels were closely correlated with MMSE-K scores(r=0.49). The group of elementary school graduates and over scored higher scores of 5-6 points and 1- 3 points higher in comparison to the noneducated group and the elementary school failure group, respectively. 3) Men received higher MMSE-K scores than women, especially in the noneducated group and the elementary school failure group. In conclusion, readjustments of MMSE-K scores for demographic variables, especially for educational level, are necessary in order to use the MMSE-K as a screening measure for dementia.
Tardive Dyskinesia 에 대한 Sodium Valproate 의 치료효과에 관한 연구
禹種仁,權俊壽,洪澤裕 大韓神經精神醫學會 1987 신경정신의학 Vol.26 No.4
We performed the double-blind placebo-controlled study to investigate the therapeutic effect of sodium valproate known as GABA-ergic agent on tardive dyskinesia. 15 out of 31 patients were treated with sodium valproate (maintenance dose: 1500-2700㎎) and the rest of them were treated with placabo over 8 weeks. We checked the severity of tardive dyskinesia by TDRS (Tardive Dyskinesia Rating Scale, Simpson et al, 1979) just before treatment, the 4th week, the 8th week and the 12th week following beginning of treatment. We checked the serum level of sodium valproate at the 4th weeks and the 8th weeks since the beginning of treatment. The results were as follows: 1) Both TDRS scores of 4th week and 8th week were significantly low compared with those of pretreatment in the group treated with sodium valproate (P<0.001), but TDRS scores returned to the pretreatment score at 12th week (4 weeks after withdrawal of medication). There was no significant relationship between serum level of sodium valproate and TDRS total scores. 2) All of the TDRS scores of 4th week, 8th week, and 12th week were significantly low compared with those of pretreatment in the group treated with placebo.(P<0.01) 3) TDRS scores of the group treated with sodium valproate were not significantly different from those of the group treated with placebo at the time prior to treatment, 4th week, 8th week and 12th week.
우종서,이해수,( Latifatu Mohammed ),고장면 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
Supercapactors are attractive for energy storage particularly in applications involving high-power requirements. Gel polymer electrolyte (GPE) is appealing in these devices due to their high ionic conductivity, electrode compactness and environmental friendliness. A nonwoven separators coated with different polymer GPE were fabricated to support and impact mechanical property to the GPEs. The coated separators exhibited ionic conductivity of 4.5×10-2, 4.2×10-2, 1.6×10-2 and 1.4×10-2S/cm for the KOH, PAAK, PVA and PEO coated separators respectively. Supercapacitors were designed with the coated separators. The capacitors were subjected to cyclic voltammetry (CV) and electrochemical impedance spectroscopy(EIS). These superior performance can be attributed to the synergistic effect of the PAN nonwoven separator and the polymer materials which have the ability to hold sufficient water in their polymer chains to enhance the needed ionic conductivity.
알쯔하이머병의 말초 생물학적 지표로서 혈청 Alpha-1-antichymotrypsin
우종인,이정희,주진형 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6
저자들은 대조군과 각 치매군의 혈청 alpha-1-antichymotrypsin(ACT) 수치를 측정하여 이것의 알쯔하이머병(AD)의 말초 지표로서의 가능성을 검토하고 혈청 ACT와 노화 과정사이의 상관성을 분석하고자 하였다. 치매의 진단을 위하여 NINCDS-ADRDA 기준을 이용하였고 혈청 ACT 수치에 영향을 미칠 수 있는 검사상의 이상자나 약물 복용자등은 연구에서 배제되었다. 최종 진단은 정신과 전문의 2명과 전공의 6명이 참여하여 합의 증례 토의를 통해서 내려졌다. 이러한 과정을 거쳐 10명의 probable AD 환자(나이 : 71.5±7.5, 범위 : 55∼82), 9명의 혈관 요인을 지닌 possible AD 환자(나이 : 72.3±8.2,범위 : 58∼89), 8명의 혈관성 치매(VD, 나이 : 72.5±9.4, 분포 : 56∼85)환자, 9명의 65세 이상의 정상 대조군(OC, 나이 : 70.9±4.6, 범위 : 66∼82저자들은 대조군과 각 치매군의 혈청 alpha-1-anti-chymotrypsin(ACT) 수치를 측정하여 ), 23명의 65세 미만의 정상 대조군(나이 : 31.2±13.0, 범위 : 21∼54)이 최종 대상군으로 설정되었다. 이들을 대상으로 72시간 단순 방사상 면역확산법을 시행하여 혈청 ACT 수치를 측정하였고 다음과 같은 결과를 얻었다. 1) Probable AD(420.0±75.6mg/L)군과 혈관 요인을 지니는 Possible AD군(443.7±54.6mg/L)의 평균 혈청 ACT 수치는 VD 환자군(483.3±89.4mg/L) 및 65세 이상의 정상대조군(OC, 382.4±20.0mg/L)과 비교하여 차이가 관찰되지 않았다. 2) VD군의 평균 혈청 ACT 수치는 OC군에 비해 의미있게 높았으며(p<0.05) 네 군을 혈관 요인이 존재하지 않는 OC과 probable AD 통합군과 혈관 요인이 존재하는 VD와 possible AD 통합군으로 재분류 하였을 때 재분류한 두 그룹사이의 평균 혈청 ACT 수치(402.1±58.3mg/L, 462.3±73.5mg/L)는 의미있는 차이를 나타냈다(p<0.05). 3) 정상 대조군의 혈청 ACT 수치는 연령이 높아짐에 따라 의미있게 증가하였다(r=0.5161;p<0.01)(Fig.3). 4) AD와 VD 환자의 clinical dementia rating, Blessed dementia scale 및 Short Blessed test 점수상의 치매의 정도와 혈청 ACT 수치 사이에는 상관 관계가 관찰되지 않았다. 이상의 결과는 혈청 ACT 수치의 증가가 치매 환자의 혈관 요인 및 정상적인 노화 과정과 연관되어 있음을 시사한다. 그러나 혈청 ACT 수치가 AD의 말초 지표일 가능성은 적을 것으로 판단된다. Objectives : The authors measured serum alpha-1-antichymotrypsin(ACT) level to elucidate its possibility to be a peripheral marker in Alzheimer's disease(AD) and to examine its relationship with aging. Methods : The subjects were 19 AD patients(age : 71.9±7.6, range : 55∼89) diagnosed by NINCDS-ADRDA criteria, 8 vascular dementia(VD) patients(age : 72.5±9.4, range : 56∼85), 32 normal control subjects(age : 42.4±21.4, range : 21∼82). Serum ACT levels were determined with radial immunodiffusion plates purchased from the Binding Site after 72-hour incubation. Results : The serum ACT levels of AD patients were not significantly different from those of old control(OC) subjects(age : 70.9±4.6, range : 66∼82), but ACT levels of VD patients were significantly higher than those of OC subjects(p<0.05). And there was significant correlation between ACT levels and age(r=0.5820, p<0.01). Conclusion : These results suggest that the increment of serum ACT level appears to be associated with the vascular component in dementia patients as well as with aging factor. However, its possibility to be a peripheral marker of AD seems to be low.