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아출(莪朮)의 Sesquiterpene 성분의 약물활성
신국현,윤기영,조태순,Shin, Kuk-Hyun,Yoon, Ki-Young,Cho, Tae-Soon 한국생약학회 1994 생약학회지 Vol.25 No.3
Pharmacological activities of two sesquiterpenes, curzerenone(I), and curcumenol(II) isolated from the rhizomes of Curcuma zedoaria being used as an aromatic stomachic in Chinese medicines were evaluated in rats and mice. Curzerenone (I), at 100mg/kg, p.o. showed a potent protective effect against HCl-ethanol induced gastric lesion in rats, and curcumenol(II), at the same dose level showed a CNS depressant action characterized by a potentiation of hexobarbital(HB)-induced narcosis. Both compounds showed a moderate analgesic action but did not exhibit a hypothermic action even at 200mg/kg dose level.
신국현,이은방,우원식 대한약학회 1970 약학회지 Vol.14 No.3,4
Anti-infalmmatory action of p-methoxycinnamic acid (p-MCA) was investigated. p-MCA showed a significant decrease in carrageenin and acetic acid induced edema of the rat hind paw, and increased capillary permeability by anaphylaxis and chemical mediators of pontamine sky blue in the mouse peritoneal cavity. It, however, showed only weak inhibitory effect on cotton pellet-induced granuloma formation of the rat.
Piperine 이 간 Micorosmal Mixed Funtion Oxidese system 에 미치는 영향
신국현,우원식 ( Kuk Hyun Shin,Won Sick Woo ) 생화학분자생물학회 1985 BMB Reports Vol.18 No.1
The effect of piperine on hepatic microsomal mixed function oxidases (MFO) was investigated. Piperine, on repeated daily administrations (100㎎/㎏, p.o. for 7 days) to mice, shortened markedly the duration of hexobarbital induced narcosis (72%) and increased aminopyrine N-demethylase (112.7%) and hexobarbital hydroxylase (78.5%) as well as in the level of cytochrome p-450 (154.2%). At pharmacologically effective doses, it did not affect MFO in vivo, whereas, it produced an inhibition of both aminopyrine and hexobarbital metabolism at a high dose (100 ㎎/㎏, i.p.). Kinetic studies on rat hepatic microsomal enzymes, in vitro, have shown that piperine gave a type I difference spectrum (max. 385㎚, min. 422 ㎚) and appeared to be a competitive inhibitor of aminopyrine N-demethylase and mixed type inhibitor of hexobarbital hydroxylase, the apparent inhibition constants (Ki) of which being 0.128 mM and 0.098 mM, respectively.
신국현,강삼식,지형준,Shin, Kuk-Hyun,Kang, Sam-Sik,Chi, Hyung-Joon 한국생약학회 1992 생약학회지 Vol.23 No.1
A new method for the analysis of coumarin constituents in the roots of Peucedanum japonicum by high performance liquid chromatography was established. Among two coumarin constituents identified, peucedanol was confirmed to be applicable to a standard compound. A reversed phase system with a ${\mu}Bondapak$ C_{18}$, column using $H_2O-MeOH=5\;:\;4$ as a moble phase was developed. Peucedanol and a minor constituent, umbelliferone were detected at 333nm and the analysis was successfully carried out within 20 min.
신국현,이은방,송영진,김운자,Shin, Kuk-Hyun,Lee, Eun-Bang,Song, Young-Jin,Kim, Oon-Ja 한국생약학회 1992 생약학회지 Vol.23 No.3
The deodorizing responses of the steam distillate from some medicinal plants(G-3) on three representative malodors were evaluated by estimating the best estimate threshold(BET) of odor responses. With a single spray of G-3, the BETs of malodors such as ammonia, acetic acid, and ethyl acetate were found to increase 4.11, 32.6 and 13.1 fold, respectively, which indicated G-3 possessed a potent deodorizing activity. The deodorizing potency of G-3 was also demonstrated to be as high as and even higher than those of the commercial deodorizing agents.