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      • 인삼이 흰쥐의 일반활동 및 굶주림에 의한 생존기간에 미치는 영향

        홍사,장현갑,홍순근 최신의학사 1972 最新醫學 Vol.15 No.1

        The effects of Panax Ginseng on general behavioral activity and survival time of food deprivated rat was studied. The occurence of component patterns of the general behavioral activity was examined by the timesample method according to Kim et al. (1970). The sleeping time of the Ginseng extract treated groups with doses of 5 and 20 mg/kg was decreased significantly than that of placebo group at night and thorughout 24 hour observation period, but no difference was observed in the day time. The frequency of eating in the two Ginseng treated groups was higher than that of placebo group at night and 24 hour observation period. The occurence of walking component in Ginseng treated group with doses of 20 mg/kg was more frequent than that of placebo group at night. Two Ginseng treated groups showed the tendency to increase in grooming, but no significant difference was observed between the treated and placebo group. No significant difference was found between treated and placebo groups with regard to lying, rearing and drinking. The gains of body weight in two Ginseng treated groups were significantly greater than that of placebo group, and the survival time with doses of 20 mg/kg was significantly longer than that of placibo.

      • SCIESCOPUSKCI등재

        A Study on the Psychopharmacological Actions of Panax ginseng in Animals

        홍사,김명석,장현갑,Hong, Sa-Ack,Kim, Myeong-Seok,Jang, Hyeon-Gap The Korean Society of Ginseng 1976 Journal of Ginseng Research Vol.1 No.1

        인삼이 중추신경계에 대한 작용을 검토하기 위한 일련의 연구로 본 연구에서는 전하 와 마우스를 사용하여 다음과 같은 몇 가지 행동연구를 행하였다. 1) 수면과 일반행동 분석 흰쥐를 사용하여 음식물이 충분한 정상상태와 96∼120시간 굶주린 절식상태에서 나타내는 일반행동을 분석하였다. 정상상태에서 100mg/kg 인삼투여 군은 대조 군에 비해 음식 먹는 회수가 유의성 있게 증가하였고, 반면 몸치장활동이 유의성 있게 감소 되었다, 96∼120시간의 절식상황에서는 두 인삼투여를 모두 대조 군에 비해 이동행동, 탐색행동과 같은 활동성이 유의성 있게 많고 장자기와 같은 무 활동성은 유의성 있게 감소되었다. 2) 조건 회피 반응 흰쥐를 사용하여 왕복 회피형 shuttle box에서 전기충격(VS)을 받지 않고 불빛(CS)에 의해 회피한 조건반응(CR)의 수를 학습의 지표로 삼아, 인삼 사포닌 2.5, 5.0, 50, 및 100mg/kg 투여 군과 식염수 군간에 성적을 비교하였다. 모든 인삼 사포닌투여 군의 성적이 식염수 대조 군에 비해 앞서는 경향이 뚜렷하지만 통계적으로 유의성 있는 경우는 2.5mg/kg경우 뿐이었다. 3) 공격적 정서반응 전기충격을 마우스의 발바닥에 가해 일어난 싸움에 인삼 사포닌이 어떠한 영향을 미치는가를 알아 보았다. 인삼 사포닌을 400 mg/kg로 투여 하면 chlorpromazine 2 mg/kg로 투여한 동물처럼 공격적 행동이 유의성 있게 감소되었다. 그러나 100mg/kg의 경우에는 이렇다 할 변화를 초래하지 못하였다. As a continuation of series of works on the pharmacological actions of Panax ginseng. three kinds of behavioral experiments were carried out using rats and mice. The occurrence of component Posterns of general behavioral activity in rat was examined by visual scanning using the ting sample method in the ad lib. And he hunger deprivated situation. In normal ad lib. situation, the eating behavior of rat treated with 100mg/kg of ginseng saponin was significantly more frequent than that of saline control at the night and throughout the 24 hr period. But grooming was less frequent than the control at the same period. In the hunger situation followed by 90~120 hrs of feed deprivation, the locomotive activity and rearing awe significantly more often and sleeping was less frequent in the two dosage g roups of ginseng saponin (10 and 100 mg/kg) than in the saline group though out the observation period. Training of avoidance conditioning in rats was done in a two-way shuttle box. The number of conditioned response (CR) in which the animal avoided sucessfully an electric shock by running in to the other compartment of the hex was regarded as an index of learning performance. Ginseng saponin in doses of 2.5 mg/kg Produced a significantly increased CR in total avoidance tria1s compared with the control. Although other dosage groups of ginseng saponin (5.0, 50mg and 100 mg/kg) showed no significant statistical difference from the normal control, it tended to increase in CR in the ginseng groups than in the control. An aggressive behavior in mice was observed in n shock-generating fighting box. The occurrence of reflexive fighting between two animals induced by an electric shock applied to the feet war checked as an index of aggression. The occurrence of reciprocal fighting episode immediately after the onset. Of the shock was significantly decreased in the dosage group of 400 mg/kg ginseng saponin, but it did net differ in the 100 mg/kg group of ginseng saponin from the control group. The dose, 400 mg/kg of ginseng saponin, inhibited fighting behavior in more than 80% of the Pairs. but 100 mg/kg of ginseng did inhibit it in less than 20% of the pairs.

      • 인삼 또는 오가피 장기투여가 닭의 산란에 미치는 영향

        홍사,Hong, Sa-Ack 대한약리학회 1981 대한약리학잡지 Vol.17 No.2

        The effects of Panax ginseng and Acanthopanax on egg production of hens are studied. The hens are fed with three dose levels of ethnaol extract of Panax ginseng and Acanthopanax for 24 months. The weight of each egg and number of egg production per month were compared between control group and treated group. The average weight of egg was not influenced by treatment of Panax ginseng and Acanthopanax. The number of egg production in control group was markedly decreased during cold season (from November to March). Panax ginseng and Acanthopanax markedly improve the egg production during cold season compared with control group.

      • SCIESCOPUSKCI등재

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