齒槽膿漏症에서 分離한 葡萄狀球菌의 性狀에 關한 硏究

金重明,河桂子,李烈熙 慶北大學校 醫科大學 1959 慶北醫大誌 Vol.2 No.1

31 strains of staphylococci were isolated from 28 cases out of 45 alveolar pyorrhoea patients. The results of the biological characters and of sensitivity tests to the various chemotherapeutic agents obtained were as follows: 1. 13 strains showed positive Coagulase test, 28 strains gave positive Haemolysin reaction, and gelatin liquefaction was observed in 2 strains of staphylococci isolated, 12 strains showed the positive Mannitol fermentation; 19 strains showed the positive results in more than two tests, and they were considered as the pathogenetic strains. 2. Generally, drun-resistant strains were found more than the sensitive ones among the isolated Staphylococci. 29 strains were resistant to chloromycetin, whereas the penicillinresistant strains were 11 out of the 31 strains. 3. No definite relationships were found between the biological characters and drugresistance.

愛生園 愛樂園 在園患者를 中心으로한 慶北道內 癩患의 疫學的 考察

金重明,李相準,河桂子,金在植 慶北大學校 醫科大學 1959 慶北醫大誌 Vol.2 No.1

During the period of November 1957 and September 1958, the epidemiological studies on lepers in Aerack and Aeseng leprosaria were made. The number of in-patients were 1,205, and that of the ambulatory patients were 2,788. It had been estimated that 0.12 percent of the population was affected by leprosy, but the male adults between 31 and 40 years of age had been more frequently enountered. For the convenience sake, we divided Kynugsang pook-do into five subareas in order to estmate their geographycal distribution, i. e., Central Area (Andong, Eisung, Chungsong, Youngchun, Guni, Sunsan, and Chilkock District) Western Area (Sangju, kimnung, Sungju District and Kimchon City) Southern Area (Taegu City, KyungSan, Talsung, Koryong, Chungdo District) Northern Area (Yongyang, Bongwha, Yechon and Munkyong District) Eastern Area (Yongduck, Yongil, Wolsung District and Kyungju City) The patient/s geographycal distribution in Kyungsang pook-do were as follows:there were 1,129 patients in Central Area, 556 lepers in southern Area, in Eastern Area three were 434 patients, in Western Area 395, and in Northern Area 269. Eisung District was found to have the largest numbers of patients and in Yongyang District the lepers were less abundant. The tuberculoid type of leprosy had been more commonly met than the other types. And it was showen that the negative results of Wades Skin Test was slightly higher in incidence.

乳兒下痢症에서 分離한 葡萄狀球菌에 關한 硏究

韓東燮,卞東吉,金炳台,河桂子 慶北大學校 醫科大學 1959 慶北醫大誌 Vol.2 No.1

During the past decade, it has been established that staphyiococci exsist as normal intestinal flora. Among these staphylococci there are a few pathogenic strains and they show their pathogenicity when there are some changes in the endogenous or exogenous on litions of the individual and cause staphylococcic enteritis. The incidence of staphylococcic enteritis seems to have increased recently after the wide use of broad Spectrum antibiotics. In an attempt evaluate the distribution of the entero-pathogenic E. coli the feces of 371 infants with diarrhea were examined. In 168 cases (45.3%) staphylococci were isolated, and in 30 cases of them the entire colonies were found to be staphylococcus and in other cases relatively many colonies of staphylococcus were found. It has been postulated that staphylococci were the cause of diarrhea in those infants. Since those infants were all new patients and had no history of administration of any antibiotics in the past, they do not seem to be the staph. enteritis which follows the use of antibiotics and it may be due to some other etiology. However, a definite conclusion can not be drown until more satisfactory clinical and bacteriological studies have been completed. Biological tests and Sensitivity tests for various antibiotics were done on the random samples of 65 strains among the 168 isolated strains and the results are as follows. 1. 25 cases (38.6%) showed gelatin liquefactin, 28 cases (42.8%) showed positive coagulase, 17 cases (26.1%) showed acid formation in mannitol, 2 cases (3.2%) showed hemolysis of rabbit R. B. C. and 62 cases (95.3%) showed hemolysis of sheep R. B. C., 15 cases (22.8%) showed more than three characteristics. These percentages are somewhat higher as composed to the staphylococci is olated from the feces of normal infants. 2. In sensitivity test, almost all strain (95.3%) were sensitive against Erythromycin, but not sensitive against sulfa-drugs. (1.5%). The percentages of the resistant strains against penicillin (73.8%) and dihydrostreptomycin (89.2%) were higher than those of the sensitive strains. The percentages of the resistant and sensitive strains against Aureomycin, Terramycin Chloromycetin and Achromycin were almost similar.

癩患者에 施行한 Tuberculin反應과 Lepromin反應 成績에 對하여

崔在圭,金重明,李相準,河桂子,卞東吉,崔炳吉 慶北大學校 醫科大學 1958 慶北醫大誌 Vol.1 No.1

Since Mitsuda established a skin reaction induced by injection of the emulsion of leprous nodule, the reaction has been called as Mitsuda reaction or lepromin reaction, and it has been considered as an important test in classifying the type of leprosy and determining the prognosis of the disease. Futhermore from the preventive point of view the lepromin test may be used in the estimation of the resistance against leprosy infection. In 1939 Fernandez found that in 97% of test was also positive. He also found that when the BCG antituberculosis vaccine was inoculated to 123 chiidren who showed negative reaction for both tuberculin and lepromin test the tuberculin reaction became positive in 99.18% and lepromin reaction in 96.86% in one month. He suggested that the BCG vaccination might have some protecting effect against leprosy infection. Azulay, Rosenberg, Neyra, Ramiras, Convit, Bundiansky, supported his idea but these have been same discussing opinions. In order to investigate this point further, I inoculated 567 leprosy patients with tuberculin and lepromin, and this observation gives us as following restults; On the lepromin reastions, in the lepromatous leprosy, the incidence of negative reactor is 1.6% higher on the 16th day (49.6%) than on the 8th day (48%). In the tubercloid leprosy, the negatives are 2.4% higher on the 16th day (32%) than rate of the lepromin reaction are generally paralled with the severity of the disease, but in tuberculoids, these are irregular. On the tuberculin reactions, in the lepromatous, the negative rate ddcreases and the positive rate increases along with severity of the disease. However, in the tuberculiod thise are irregular. When a comparison is made between the lepromin reaction (on the 16th day) and the tuberculin reaction in the lepromatous and tuberculoid types, in the lepromatous type, the lepromin negatives are 9.3% more than tuberculin negative, the lepromin doubtfuls are 3% more than the tuberculin and the positive are 12.2% less than the tuberculin. In the tuberculoid type, the lepromin negative are 6% less than the tuberculin negatives. The lepromin doubtfuls are 2.8% less than the tuberculin. When the lepromin and tuberculin reactors are compared, as a whole, on the 8th day, the lepromin negative are 0.4% more than those of tuberculins, but the lepromin positives are 0.4% less than the tuberculin. On the 16th day, the lepromin negative are 2.3% the lepromin doubtful cases are 0.7% more than those of tuberculins, but the lepromin positive are 3.3% less than the tuberculin positives. In the same patients, the same reactions are 48.3%, the opposite reactions are 32.9% and 18.7% are others. It is suggested that there are certain immunological relations between the lepromin and tuberculin reactions and especially in the lepromatous leprosy, the tuberculin reaction might be used in classification and determination of the severity of the disease as the lepromin reaction.

癩患者에 施行한 癩菌檢査成績

崔在圭,金重明,李相準,河桂子,卞東吉,崔炳吉,徐舜鳳 慶北大學校 醫科大學 1958 慶北醫大誌 Vol.1 No.1

Leprosy bacilli are investigated from the skin surface of leprosy patients by wade's scraped incisionmethod. It was observed the relation which is between appearance of leprosy bacilli and, Type and severity of the disease, age, the duration of the disease treatment, and the te lepromin reaction. And these observation gave us as following results. Total cases was emplied 800: of then 277 cases (34.63%) were revealed the leprosy bacilli. On the leprosatons type and Bordiline group the apperance of leprosy bacilli are higher than the tuberculoid type in the type and severity of the disease, and this appearing rate increased along with severity of the disease On the age range, the most positive rate of leprosy bacilli was from 56 years to 60 years, the least one was from 11 yeears to 15 years. On the duration of the disease generally, the longer durations of the disease have the more the incidence of leprosy bacilli positive show, The positive rate of leprosy bacilli was on 34 years, highest the least one was on 7 years. On the duration of abmission in the leprosarium, there were many positive cases of leprosy bacilli. Thus facts must be discussion about the therapeutic methods and control of leprosar a On the lepromin reaction, total cases were emploied 369, of whith 113 cases were represeted leprosy bacilli, and 57% of them was the lepromin positive reactor, while, 43% of them was the lepromin negative reactor. The leprosy bacilla positive with the lepromin negative reactor was 15.4% of 369 cases, the leprosy bacilli negative with the positive lepromin reactor was 42%, the leprosy bacilli negative with the negative lepromin reactor 27.3% the positive leprosy bacilli with the positive lepromin reactor was 15.2% of

乾燥 BCG-Vaccin에 依한 Lepromin 反應의 影響에 對해서

崔在圭,金重明,李相準,河桂子,卞東吉,崔炳吉,徐舜鳳 慶北大學校 醫科大學 1958 慶北醫大誌 Vol.1 No.1

Since 1939, Fernandez had reported on the tuberculin and lepromin test, prophylaxy of leprosy by inocculating with BCG was also suggssted by him, and Azulay, Rosenberg, Neyra, Ramirez, Convit, Bundiansky and others were agreable by their furthermore invstigation, but some othsrs discussed. Recently in Japan, Mayama showed that a fraction of serum protein induced from human and rat leprosy has been an inhibitory growing factor of tubercle bacilli. On the other hand Gawaguch said that the haemoagglutination test was to be stronger positive not only with tuberculous patient's serum, cut with serums of human and rat leprosy. From Feb. to Sept. in 1957, we inocculated with dry BCG Vaccine to 116 cases of untainned children of leprosy at Sam Hyuck Preventorium in Taegu city, and observed the influences of lepromin reaction by vaccination of dry BCG, and dividing A.B. and C group of all cases according to its given conditions observed results are as follow;. In the A group (53 casss), 13 cases of the lepromin negative 3 cases of them were turned to be lepromin positive by firs vaccination of BCG. After 2 months later, and lepromin positives increased to 2 cases by second inocculation, after 5 months later. And there were 15 cases of the leptomin negative in the B group, (52 casss) 4 cases of them covnerted to be lepromin positive by vaccination of BCG after 5 months later. In the C group (11 case) 3 cases were negative, one case of them turned to be positive. Of the total cases, there were some cases which a lepromin positive reactor inverted to be negative and which a lepromin negative fixed parmanentely for the negative nevertheless. Generally, the lepromin negative reactors were 31 cases in total (116 casss), 10 cases of them (31 cases) converted to be lepromin positive. As above, Vaccination of BCG enables the lepromin negative to convert to be lepromin positive. Especially, it is most important things to in occulats with BCG to the untainned children for prevention of leprosy and tuberculosis.