기관지 재건술

池幸玉 대한의학협회 1994 대한의학협회지 Vol.37 No.8

박리성 대동맥류

池幸玉 대한의학협회 1992 대한의학협회지 Vol.35 No.12

폐암환자의 혈청 Ribonuclease의 활성도와 분리에 대한 연구

이재원,고재경,지행옥 한양대학교 의과대학 1990 한양의대 학술지 Vol.10 No.1

Activities of acid deoxyribonuclease (DNase), acid ribonuclease (RNase), neutral RNase and alkaline RNase were determined in serum and cancer tissues of patients with epidermoid carcinoma, adenocarcinoma, small cell carcinoma and large cell carcinoma of lungs to find out the interrelationships of the enzymes between serumand the cancer tissues and the possibility of using thses enzyme parameters for biochemical and diagnostic markers for the lung cancer. Also investigated were presence of RN ases specific to lung cancer, separating serum RNase proteins by a phosphocellulose column chromatography. 1) Activity of acid DNase increased significantly in the tissue of all types of lung cancer tissues(p<0.05), but was not detected in serum. 2) Activity of acid RNase in the tissue increased in all four types of lung cancer by the average increment of 43% (p<0.05). The activity of neutrla RNase, however, increased only in the types of small cell and large cell carcinoma. 3) Acitivities of acid, neutral and alkaline RNases in the serum of the patients of lung cancer showed significant increase by the average increment of 69%, 59% and 70%, respectively(all p<0.01), suggesting that the activity of serum RNase might be used as a diagnostic marker in the lung cancer. The increase in the activity of the serum RNase was more prominent in the epidermoid carcinoma than in other types of lung cancer. 4) Serum proteins of epidermoid lung cancer was separately by a phosphocellulose column chromatography into 10 peaks, of which 5 peak proteins exhibited RNase activity. No proteins and RNases specific to the lung cancer was observed. Multiple activation and suppression of proteins and RNases normally present in serum were seen in the cancer serum, suggesting the multifunctional roles of RNase in the cancer.

흉부외상환자에서 응급치료를 요하는 질환

池幸玉 대한의사협회 1996 대한의사협회지 Vol.39 No.10

나보다는 우리를

지행옥 대한결핵협회 1994 보건세계 Vol.41 No.3

Cadmium Chloride가 흰쥐 폐포간 중격에 미치는 영향에 관한 전자현미경적 연구

오상준,지행옥 한양대학교 의과대학 1993 한양의대 학술지 Vol.13 No.1

It is known that cadmium, heavy metal, is very harmful and toxic to human bodies. Therefore, the chronic effects of cadmium chloride on the ultrastructures of rat alveolar septum were studied in 40 adult male rats (Wistar strain) by electron microscopy. Rats were intraperitoneally injected, once a week for 10 weeks, with cadmium cholride (3.75 mg/kg body weight) or saline as control. Animals were sacrificed 1 day, 1 week, and 2 weeks after the last injection. 1. in 1-day grou., large expanded air sacs were developed between the basal lamina and endothlial cells of capillaries. In the cytoplasm of great alveolar cell, lamellation of lamellated bodies was reduced and the smooth surfaced endoplsmic reticulum was in creased. 2. In 1-week group, alveolar wall capillaries were dilated and numerous areas of edema were seen in the alveolar septum. Great alveolar cells and fibroblasts were increased in number. 3. In 2-week group, the find structures of alveolar septum were intact such that they were similar to those of controls In conclusion, these findings suggest that cadmium chloride causes morphological changes of the lung alveolar septum in rats. Those changes, however, seem to normalize within 2 weeks following the last dose of cadmium chloride.

각혈을 동반한 결핵성 농흉 및 기관지늑막루의 환자에서 늑막 및 전폐절제술후 다량의 출혈환자의 치험 1례

지행옥 대한흉부심장혈관외과학회 1989 Journal of Chest Surgery (J Chest Surg) Vol.22 No.5

There appears to be significant problems remained in the treatment of tuberculous empyema with BPF in spite of several surgical methods: decortication, thoracoplasty, and pleuropneumonectomy. We presented one case of tuberculous empyema with BPF. The patient was 42-year-old male and his chief complaint was hemoptysis. In past history, he was treated with left closed thoracostomy and antituberculous medication for two months, 16 years ago. Chest X-ray, tomogram and C. T, revealed a huge mass with central necrosis in the lower 2/3 of left thoracic cavity and shifting of the mediastinal structure to the right. Needle aspiration cytology was undifferentiated large cell carcinoma. Left thoracotomy was made under the impression of lung cancer and pleuropneumonectomy was done. Operative findings; thick walled empyema sac filled with hematoma and BPF, the mediastinum was fixated due to fibrosis and calcification of the pleura and the mediastinum. Postoperative biopsy was consistent with tuberculosis. In the postoperative course, there was massive hemorrhage and so reoperation was done. But there was no active bleeding focuses in the thoracic cavity at the time of reoperation. Massive transfusion, coagulant therapy and intermittent clamping and declamping of the chest tube were carried out. Especially, serum calcium level was chronically decreased and so large amount of calcium gluconate was infused for the calcium level to be normal. Total transfused blood; whole blood was 33 pints, packed cell was 63 pints and fresh frozen plasma was 70 pints. At the postoperative[reop] 45th day, intrathoracic hemorrhage was stopped and the chest tube was removed. In conclusion, this suggest that uncontrollable bleeding after pleuropneumonectomy of the tuberculous empyema with BPF could be treated without reoperation in case of the mediastinal fixation due to fibrosis and calcification of the pleura and the mediastinum.

생선뼈'에 의한 식도천공의 외과적 치료: 4례 보고

지행옥,김근호 대한흉부심장혈관외과학회 1973 Journal of Chest Surgery (J Chest Surg) Vol.6 No.1

This is a report on a total of four cases of esophageal perforation due to fish bone in the Department of Thoracic Surgery, Hanyang University Hospital. The perforated portions of esophagus were upper third of esophagus, that is, cervical esophalgus principally. The complications after esophageal perforation were acute mediastinitis with mediastinal emphysema in 2 cases, acute mediastinitis with both pyothorax in one case and cervical subcutaneous abscess alone in one case. Collar mediastinostomy was required to control disturbance of cardiopulmonary function as emergency procedure. Gastrostomy was of worthy for the various purposes, that` is, for feeding, absolute rest of the esophagus, and for prevention against continuous infection from esophageal leakage. After the gastrostomy. 3 cases were healed by spontaneous closure of esophageal perforation between one to four weeks. One case expired from severe septic shock due to acute diffuse mediastinitis and both pyothorax.

양성 종격동종양의 외과적치료에 대한 임상적 고찰

지행옥 대한흉부심장혈관외과학회 1970 Journal of Chest Surgery (J Chest Surg) Vol.3 No.2

This is a report on a total of 8 cases of benign mediastinal tumors and cysts in Department of Thoracic Surgery, Chonnam University Hospital during the period from 1961 to 1969. The patients age was distributed between 18 and 38 year old with the highest incidence in the age group of second decade. Sex ratio of male to female was 3: 5. The tumors were classificed as follow; 3 case:, of neurogenic tumors, 2 cases of teratomas, one case of pericardial cyst, one case of cystic hygroma, and one case of brochogenic cyst. The symptomatic patients were 5 cases(62. 6%) and asymptomatic patients were 3 cases(37.5%). The symptomatic patients had the symptoms not referable to their lesion and the mediastinal tumors of asymptomatic patients were incidently found by routine chest X-ray. The Symptoms occurred by compression to adjacent nerve system in 3 cases. by perforation into the lung with infection in one case and by infection of bronchial cyst in one case. The complications were Pancoast's syndrome including Horner's syndrome(2 cases), middle lobe syndrome (one case), bro:1chial infection(one case) and intercostal neuralgia(one case). All tbe tumors were surgicai[y resectable with good recovery postoperatively. In 5 cases of the symptomatic patents, their symptoms were disappeared dramatically after operation.

심장혈관수술 1597례에 대한 임상적 고찰 (개심술 ,1005례 보고)

지행옥 대한흉부심장혈관외과학회 1988 Journal of Chest Surgery (J Chest Surg) Vol.21 No.3

1,597 cases of operation on the cardiovascular disease were performed at the Hanyang University Hospital from 1972 to 1987. Of these, 1,005 cases were open heart surgery. It was started from July 1975. Among the open heart cases, 725 were congenital heart diseases and 280 were acquired heart diseases. In congenital heart cases, 554 were acyanotic and 171 were cyanotic. The operative results were as follows; the overall mortality of cardiovascular surgery was 7.1%, the open heart mortality was 9.5%. This analyses were reported in memory of the achievement of 1,000 cases of open heart surgery.