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요양시설 규모에 따른 직원의 감정노동, 직무만족이 조직몰입에 미치는 영향
장혜영,송은옥,서유진 한국지역사회간호학회 2020 지역사회간호학회지 Vol.31 No.1
Purpose: The purpose of this study was to identify the factors influencing organizational commitment of staffs according to the size of long-term care facility. Methods: A cross-sectional descriptive study was designed. Data collection was conducted for a total of 315 employees in long-term care facilities located in Seoul, Gyeonggi, Gangwon, Gyeongbuk, and Chungnam. Data were collected from July 2018 to October 2018 using questionnaires which included emotional labor, job satisfaction, organizational commitment, and general characteristics. In order to confirm the differences in the size of the facility, the facilities with less than 30 beds, those with 30-99 beds, and those with more than 100 beds were analyzed. Data were analyzed using descriptive statistics, t-test, ANOVA, Mann-Whitney U test, Kruskal-Wallis H test, Pearson’s correlation analysis, and multiple regression. Results: The job satisfaction and organizational commitment were significantly different according to the size of long-term care facility. Organizational commitment was influenced by ‘external job satisfaction’ in less than 30 beds, was influenced by ‘external job satisfaction, and attentiveness to required display rules of emotional labor’ in 30~99 beds, and then was influenced by ‘type of job, and internal job satisfaction’ in more than 100 beds. The predict variables accounted for 23.0%, 41.0%, and 34.0% of organizational commitment respectively. Conclusion: These findings show that tailored interventions should be provided depending on the size of facility in order to increase organizational commitment. In addition, organizational commitment programs should be developed by considering strategies to reduce the emotional labor and to increase job satisfaction.
우리나라 청소년의 COVID-19로 인한 가정경제악화가 자살생각에 미치는 영향
장혜영,김소영 보건의료산업학회 2022 보건의료산업학회지 Vol.16 No.2
Objectives: This study aimed to investigate the effect of the deterioration of the household economy due to COVID-19 on adolescents’ suicidal ideation. Methods: Using data from the 16th Adolescent Health Behavior Survey (KYRBS), 2020, this cross-sectional study included 54,948 adolescents. We evaluated the deterioration of household economic conditions and suicidal thoughts due to COVID-19 through subjective, non-face-to-face online interviews. Data were analyzed using descriptive statistics, chi-square tests, and logistic regression. Results: The overall prevalence of suicidal thoughts in the study population was 10.9%. People whose household economy deteriorated due to COVID-19 had more suicidal thoughts than those whose economy did not deteriorate. Worse (aOR=1.548, 95% CI=1.437–1.667, very worse (aOR=2.489, 95% CI=2.242–2.763) based on no economic deterioration. Conclusions: Rather than relying on self-reports of suicidal ideation due to COVID-19, objective measurement and research is needed on this subject.
ATF2 전사인자의 발현과 AP-1 전사인자인 BATF, c-Fos, c-Jun과의 이량체 형성
장혜영,김재호,Jang Hye-Young,Kim Jae-Ho 한국생명과학회 2005 생명과학회지 Vol.15 No.6
ATF2는 c-Fos와 c-Jun과 같은 전사인자이며 이들은 루신지퍼 단백질이다. 루신지퍼 단백질은 동형이합체 혹은 이형이합체를 형성하며 promoter 영역에 결합하여 전사조절에 중요한 역할을 한다. 세포의 전사인자 ATF2는 ATF/CRE site에 결합하며 특히 선택적인 interfamily 이형이량체를 형성함으로써 전사 조절에 있어서 다양한 메카니즘을 제공할 수 있다. 본 연구에서는 ATF2 cDNA를 6xHis를 가진 expression vector에 subcloning하여 E.cnli BL2l에서 발현시켰다. 6xHis tag은 nickel-chelating chromatography를 가능하게 하였다 발현된 ATF2는 In vitro binding pull-down assay에서 동형이합체를 이를 뿐만 아니라 AP-1 그룹의 인자들과 선택적인 이형이합체를 형성함을 보여 주었다. BATF와는 강하게 결합하였으며 c-Jun과도 안정된 이합체를 형성하였다. 그러나 c-Fos와는 이합체를 형성하지 않으므로서 AP-1그룹 내에서도 이합체 형성이 선택적으로 이루어짐을 알 수 있다. ATF2 is a cellular transcription factor which belongs to the CREB/ATF class and it is leucine zipper protein which generally binds to DNA as dimers. This paper presents the procedure for subcloning the ATF2 gene and the results of experiment used the expressed ATF2. The pET expression vector was used since it produced 6xHis fusion protein for easy purification using affinity column. The Nickel chelating chromatography was used for Purifying the expressed ATE2 from E- codi BL2l. Subsequen시y In vitro binding pull-down assay showed the binding specificity of ATF2 with AP-1 family factors such as BATF, c-Fos, c-Jun and ATF2 itselgf. ATF2 forms homodimer as well as strong heterodimer with BATF. It also forms stable dimer with c-Jun but barely binds with c-Fos.
미-중 무역 분쟁과 2018년 미국 주지사 선거: 주지사 선거는 국제경제 변화에 영향을 받는가?
장혜영 서울대학교 미국학연구소 2019 미국학 Vol.42 No.1
Do international economic factors affect the result of gubernatorial elections? This research aims to explain the reasons that local elections are not influenced by international economic factors such as US-China trade dispute. Although previous studies show the mixed results about the relationship between economic factors and gubernatorial electoral outcome, this research argues at least three explanations can be identified. First, there is a perceived gap between the candidates and local voters on the effect of trade disputes. Local voters do not consider the trade dispute as immediate threats, and candidates only use the trade dispute for attacking rivals. Where the functional responsibilities are unclear among elected officials between federal and local government, voters tend to cast votes based on their party identification. In the case of trade policy, functional responsibility is murky between the president and governor; voters may not judge the governor incumbent or candidates on state economic condition.
장혜영 고신대학교 자연과학연구소 2008 고신대학교 자연과학연구소 논문집 Vol.15 No.-
BATF는 leucine zipper (bZIP) 전사인자의 한 family 이다. BATF는 AP-l을 수반하는 gene expression의 효과적인 억제자임이 증명되었다. 본 연구에서는 BATF hinge 지역의 인산화의 기능적인 분석을 위하여 BATF 비nge 지역의 돌연변이 (T48D)를 형성하였다. 뻐1 do뼈 as잃y는 T48D(mutant)와 wild type BATF 단백질이 BATF, c-Fos, c-Jun과 같은 AP-l family factors 와의 선택적인 in vitro dimer 형성의 특성을 보여 주었다. 또한 BIFC (Bimolecular Fluorescence Complementation)를 통하여 생체 내에서의 BATF와 T48D 사이의 이량체 형성의 결합강도를 제시하였다.