http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 延海壽 (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Indomethacin Lysinate의 藥劑學的 硏究
李琬夏,延海壽 成均館大學校 科學技術硏究所 1984 論文集 Vol.35 No.2
Pharmaceutical Studies on Indomethacin lysinate At the present time, a major problem in the management of inflammatory and degenerative arthritis has been found in anti-inflammatory analgesic drug which combines potency with safety. Furthermore, the will-established agents in current use, including salicylates, corticosteroids, phenylbutazone, and ketoprofen, have ulcergenic properties as well as other serious toxic or side effects while the efficacy of other, safer drugs such as ibuprofen has been questioned. Considering these problems, indomethacin, 1-(p-chloro benzoyl)-5-methoxy-2-methyl-3-indolyl acetic acid which is a first non steroidal antiinflammatory drug has many advantages in pharmaceutical efficacy to the above drugs and has been used all over the world. But, according to reports, indomethacin is not well tolerated by patients and has a very high incidence of side effects and toxic reactions. In particular, overt gastrointestinal bleeding has been reported. The physical properties of indomethacin make difficulties in preparing of pharmaceutical preparations because of its water insolubility. In order to make soluble in water, indomethacin was made as lysine salt, such as acetylsalicylic acid lysine salt, ibuprofen lysine salt, ketoprofen lysine salt and amino acid salt of phenylbutazone. The purposes of this study was to make a comparison between indomethacin and indomethaein lysine salt in aspects of analgesic, anti-inflammatory, antipyretic effect and blood concentration. The experimental results were summerized as followings. 1. Indomethacin lysinate was composed of one molecule of indomethacin and one molecule of lysine. The product which lyophilized was water soluble and melting point was 223℃. 2. Indomethacin lysinate showed about 2 times stronger analgesic effect than that of indomethacin. 3. In antipyretic effect, it was found that the body temperature of rabbit returned to normal after 3 hours in indomethacin while after 1 hour in indomethacin lysinate. 4. Indomethacin lysinate showed about 10% stronger anti-inflammatory effect than that of indomethacin and continued as same pattern until 5 hours later. 5. LD_50 of indomethacin lysinate was 1.8mg/kg higher than that of indomethacin, suggesting indomethacin lysinate as safer drug. 6. Indomethacin lysinate showed 99% dissolution rate in H_2O, 95% in pH 7.2 buffer solution while it showed 20% dissolution rate in pH 4.2 buffer solution. 7. In isolated intestinal absorption test, indomethacin lysinate showed about 20-30% higher absorption rate until 3 hours later than that of indomethacin. 8. Elimination rate constant of indomethacin lysinate was shown as 0.016 in I. V. injection while that of indomethacin was 0.023. Indomethacin lysinate showed higher remaining plasma concentration until 50 minutes later than that of indomethacin. 9. Blood concentration of indomethacin lysinate was 2~3 times higher than that of indomethacin in oral administration and continued as same pattern until 3 hours later. Both drugs, indomethacin and indomethacin lysinate showed pick level plasma concentration after 2 hours in oral administration. 10. Blood concentration of indomethacin lysinate was higher than that of indomethacin until 80 minutes later in I.M. injection. From the above results, it can be concluded that lysine salt of indomethacin is less potent, more effective, safer drug than indomethacin itself.
-
李琬夏,柳柄泰,延海壽 成均館大學校 1980 論文集 Vol.28 No.-
The results on the analysis of cimetidine tablets and injections by UV determination, colorimetric determination and HPLC determination are as follows; 1. Cimetidine tablet can be easily made by wet granulation method and diluents in core tablets and film coating tablet do not interfere with analysis. 2. Cimetidine injections are made by aseptic manipulation or autoclaving. When they are adjusted approximately to pH 6.0 because they are stable under the strong acidic condition, they have high stability without the performance of complicated aseptic manipulation 3. UV determination shows more stable absorption spectrum by the Me-OH than by the 0.01-HCL as a solvent. It can be considered as a desirable quantitative analysis for cimetidine material. 4. Colorimetric derermination shows much better results by the BCG dye than by BTB dye. BCG dye doesn't be affected by diluents in tablets and preservatives in injections. 5. HPLC determination using the μBondapak C_18 column can be used for the quantitative analysis of cimetidine preparations. It shows the peak of main component in 1 minute after injection of sample. Compared with other analytical methods, HPLC determination is recognized as a desirable analytical method because of its high representation and short time for measuring the content uniformity in cimetidine preparations.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
