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RISS 인기검색어
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- 저자 : İsmail Koyuncu (검색결과 3 건)
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Hamza Ayaydın,Adnan Kirmit,Hakim Çelik,İsmail Akaltun,İsmail Koyuncu,Şermin Bilgen Ulgar 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.2
Objective: The purpose of this study was therefore to investigate whether neuronal, axonal, and glial cell markers (Neuron-specific enolase [NSE], tau, serum 100 beta protein [S100B], respectively) and apoptosis markers (active caspase 3, M30, M65) and whether these parameters can be used as diagnostic biomarkers in autism spectrum disorders (ASD). Methods: This study measured the serum S100B, NSE, tau, active caspase 3, M30, and M65 levels in 43 patients with ASD (aged 3−12 years) and in 41 age- and sex-matched healthy controls. ASD severity was rated using the Childhood Autism Rating Scale. The serum levels were determined in the biochemistry laboratory using the ELISA technique. The receiver operator characteristics curve method was employed to evaluate the accuracy of the parameters in diagnosing ASD. Results: Serum S100B, tau, NSE, active caspase-3, M30, and M65 levels were significantly higher in the patient group than in the control group (p < 0.001, p = 0.002, p = 0.002, p = 0.005, p < 0.001, and p = 0.004, respectively). The cut-off value of S100B was 48.085 pg/ml (sensitivity: 74.4%, specificity: 80.5%, areas under the curve: 0.879, p < 0.001). Conclusion: Apoptosis increased in children with ASD, and neuronal, axonal, and glial cell injury was observed. In addition, S100B may be an important diagnostic biomarker in patients with ASD. Apoptosis, and neuronal, axonal and astrocyte pathologies may play a significant role in the pathogenesis of ASD, and further studies are now required to confirm this.
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Mücahit Kahraman,Sabri Yurtseven,Ebru Sakar,Aydın Daş,Hamza Yalçın,Gülşah Güngören,Mustafa Ünal Boyraz,İsmail Koyuncu 한국축산식품학회 2023 한국축산식품학회지 Vol.43 No.1
This study was carried out to determine the effects of adding pistachio shell (PIS), pomegranate hull (POM), and olive pulp (OP) to the diet on milk amino acid and fatty acid parameters in Awassi sheep. In the study, 40 head of Awassi sheep, which gave birth at least twice, were used as animal material. Sheep were fed a control diet without added byproducts (CON), rations containing PIS, POM, and OP. Milk amino acid profile was determined by liquid chromatography-tandem mass spectrometry, milk fatty acid gas chromatography-flame ionization detection device. There was a dramatic reduction in alanine, citrulline, glutamine, glutamic acid, glycine, leucine, ornithine and alphaaminoadipic acid in the research groups. In the PIS group, argininosuccinic acid, gammaminobutyric acid, beta-alanine and sarcosine; In the POM group, asparagine, gammaminobutyric acid, beta-alanine, and taurine; In the OP group, a significant positive increase was found in terms of alanine, histidine, gammaminobutyric acid, and taurine amino acids. The applications in the study did not have a statistically significant effect on the ratio of short, medium and long chain fatty acids in milk (p>0.05). In the presented study, it was determined that PIS, POM, and OP, which were added to the sheep rations at a rate of 5%, caused significant changes in the milk amino acid profiles. In this change in milk amino acid profiles, the benefit-harm relationship should be considered.
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Ambarita Aulia Chintia,Mulyati Sri,Arahman Nasrul,Bilad Muhammad Roil,Gül Bahar Yavuztürk,Korkut Sevde,Koyuncu İsmail 한국화학공학회 2024 Korean Journal of Chemical Engineering Vol.41 No.4
Dragon blood resin (DBR) has been reported as an eff ective bio-based additive for polymeric membrane fabrication. It improves permeability and antifouling properties, but its weak chemical bond makes it susceptible to leaching. This study investigates the chemical stability and leaching behavior of polyethersulfone (PES) membranes modifi ed with DBR in an alkaline solution. The study involved immersing two types of PES-based membranes, one loaded with 3% DBR (M-3) during the fabrication and one without (M-0), in a 0.01-N NaOH solution for 5 days. The results show that M-0 had good resistance to high alkaline solutions, while M-3 was less stable. Pure water permeability and water contact angle increased with immersion time, with an average percentage increase of 90.74 and 19.48%, respectively. The leaching of DBR from the PES membrane could be attributed to its polarity and the breaking of the DBR bonds, causing them to break apart into smaller molecules. The leaching of DBR also leaves a void that increases the pore size. This report provides useful information for the optimal design of a bio-based PES membrane.
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