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Miyu Tanaka,Yuta Yoshino,Shogo Takeda,Kazuya Toda,Hiroshi Shimoda,Kazuhiro Tsuruma,Masamitsu Shimazawa,Hideaki Hara 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.10
Sarcopenia, loss of muscle mass and function, is mainly observed in elderly people. In this study, we investigated whether fermented rice germ extract (FRGE) has some effects on the mouse gastrocnemius muscle by using behavioral and morphological analyses, Western blotting, and a murine model of immobilization-induced muscle atrophy. Daily oral FRGE administration increased muscle weight and strength. In addition, myofiber size in gastrocnemius muscle of FRGE-treated mice was increased as revealed by morphological quantification. Activation of AMP-activated protein kinase (AMPK) signaling, which inhibits protein synthesis and stimulates protein degradation in gastrocnemius muscle, was significantly attenuated in the FRGE-treated mice compared with control mice. Expression level of forkhead box 3a (FOXO3a) protein was also significantly decreased in the FRGE-treated group. Moreover, the decrease in mean myofiber cross-sectional area in immobilized hindlimb in vehicle-treated mice was inhibited by FRGE treatment in histological analysis. In conclusion, FRGE increased the strength and weight of gastrocnemius muscle and myofiber size, and reduced immobilization-induced muscle atrophy in mice. These findings indicated that FRGE might be beneficial in preventing motor dysfunction in a range of conditions, including sarcopenia.
Napoleon Enteria,Hiroshi Yoshino,Akashi Mochida,Rie Takaki,Akira Satake,Seizo Baba,Yasumitsu Tanaka 대한설비공학회 2015 International Journal of Air-Conditioning and Refr Vol.23 No.4
The desiccant-based air-conditioning system consists of many heat and mass transfer components operating together with air fans. The performance test using the multiple tracer gas dilution method is important for knowing the internal and external flow rates, including the air leakages. The results of the test show the actual internal air flow rates and the sources of air leakage, and also show the interaction of air in the air-conditioned lecture room and in the mechanical room. The performance test using the multiple tracer gas dilution method in air flow and air leakages is important for a detailed evaluation of any air-conditioning system such as this desiccant-based one.
Nagaoka, Hiroaki,Wakabayashi, Keiji,Kim, Seon-Bong,Kim, In-Soo,Tanaka, Yoshino,Ochiai, Masako,Tada, Akihiro,Nukaya, Haruo,Sugimura Takashi,Nagao, Minako 國立統營水産專門大學 附設 水産科學硏究所 1993 수산과학연구소보고 Vol.4 No.-
We examined the reactivity of the N-hydroxyamino derivative of a carcinogenic heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), after its O-acetylation with four 2'-deoxyribonucleoside 3'-monophosphates. ^32P-Postlabeling analysis demonstrated that the levels of adducts with 2'-deoxyguanosine 3'-monophosphate were much higher than those with the other three nucleotides. ^IH-NMR, mass spectral and UV absorption spectral analyses of the major adducts formed by N-acetoxy-PhIP with 2'-deoxyguanosine and with its phosphate esters indicated that PhIP bound at the C-8 position of guanine, as previously demonstrated with other heterocyclic amines.